University of New Mexico

About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.

Neoliberalism and the Transformation of Populism in Latin America: The Peruvian Case

Abstract: Latin American populism is generally associated with the developmental stage of import substitution industrialization; it is thus widely presumed to have been eclipsed by the debt crisis of the 1980s and the free market reforms of the neoliberal era. However, the leadership of Alberto Fujimori in Peru suggests that new forms of populism may be emerging despite the fiscal constraints of neoliberal austerity. This new variant of populism thrives in a context where economic crisis and social dislocation undermine traditional representative institutions, enabling personalist leaders to establish unmediated relationships with heterogeneous, atomized masses. Political support can be cultivated through populist attacks on entrenched political elites or institutions, along with targeted but highly visible poverty alleviation programs. This new form of populist autocracy complements the efforts of neoliberal technocrats to circumvent the representative institutions that are integral to democratic accountability. The Peruvian case thus demonstrates that populism has been transformed rather than eclipsed during the neoliberal era and that it should be decoupled theoretically from any particular phase or model of economic development.

The New Paradigm Wars: Is There Room for Rigorous Practitioner Knowledge in Schools and Universities?

Abstract: ccording to Schon (1995) "the new scholarship" implies "a kind of action research with norms of its own, which will conflict with the norms of technical rationality-the prevailing epistemology built into the research universities" (p. 27). The "battle" of snails that Schon refers to echoes the "paradigm wars" among "positivists," interpretivists, and critical theorists, satirically described by Gage (1989) in the pages of Educational Researcher. While we believe that practitioner research cannot be subsumed under any of Gage's three paradigms without doing it damage, our purpose in this article is not to argue for separate paradigm status. Nevertheless, we believe that the insider status of the researcher, the centrality of action, the requirement of spiraling self-reflection on action, and the intimate, dialectical relationship of research to practice, all make practitioner research alien (and often suspect) to researchers who work out of Gage's three academic paradigms. If anything, academic traditions of feminist and poststructural research might be more compatible with these characteristics. It is interesting to speculate on why metaphors of war and battles are evoked to discuss these epistemological debates. While it could be attributed to the academic version

The ring laser gyro

Abstract: This paper presents a review of both active and passive ring laser devices. The operating principles of the ring laser are developed and discussed, with special emphasis given to the problems associated with the achievement of greater sensitivity and stability. First-principle treatments of the nature of quantum noise in the ring laser gyro and various methods designed to avoid low-rotation-rate lock-in are presented. Descriptions of state-of-the-art devices and current and proposed applications (including a proposed test of metric theories of gravity using a passive cavity ring laser) are given.

JAK mutations in high-risk childhood acute lymphoblastic leukemia.

Abstract: Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations. Mutation of genes encoding tyrosine kinases is uncommon in ALL, with the exception of Philadelphia chromosome-positive ALL, where the t(9,22)(q34;q11) translocation encodes the constitutively active BCR-ABL1 tyrosine kinase. We recently identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients characterized by deletion of IKZF1 (encoding the lymphoid transcription factor IKAROS) and a gene expression signature similar to BCR-ABL1-positive ALL, raising the possibility of activated tyrosine kinase signaling within this leukemia subtype. Here, we report activating mutations in the Janus kinases JAK1 (n = 3), JAK2 (n = 16), and JAK3 (n = 1) in 20 (10.7%) of 187 BCR-ABL1-negative, high-risk pediatric ALL cases. The JAK1 and JAK2 mutations involved highly conserved residues in the kinase and pseudokinase domains and resulted in constitutive JAK-STAT activation and growth factor independence of Ba/F3-EpoR cells. The presence of JAK mutations was significantly associated with alteration of IKZF1 (70% of all JAK-mutated cases and 87.5% of cases with JAK2 mutations; P = 0.001) and deletion of CDKN2A/B (70% of all JAK-mutated cases and 68.9% of JAK2-mutated cases). The JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL, and they had a poor outcome. These results suggest that inhibition of JAK signaling is a logical target for therapeutic intervention in JAK mutated ALL.