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Institution

University of New South Wales

EducationSydney, New South Wales, Australia
About: University of New South Wales is a education organization based out in Sydney, New South Wales, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 51197 authors who have published 153634 publications receiving 4880608 citations. The organization is also known as: UNSW & UNSW Australia.


Papers
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Journal ArticleDOI
TL;DR: Unraveling the cellular and molecular requirements underlying Tfh cell formation and maintenance will help to identify molecules that could be targeted for the treatment of immunological diseases that are characterized by insufficient or excessive Ab responses.
Abstract: The generation of high-affinity antibodies (Abs) plays a critical role in the neutralization and clearance of pathogens and subsequent host survival after natural infection with a variety of microorganisms. Most currently available vaccines rely on the induction of long-lived protective humoral immune responses by memory B cells and plasma cells, underscoring the importance of Abs in host protection. Ab responses against most antigens (Ags) require interactions between B cells and CD4+ T helper cells, and it is now well recognized that T follicular helper cells (Tfh) specialize in providing cognate help to B cells and are fundamentally required for the generation of T cell–dependent B cell responses. Perturbations in the development and/or function of Tfh cells can manifest as immunopathologies, such as immunodeficiency, autoimmunity, and malignancy. Unraveling the cellular and molecular requirements underlying Tfh cell formation and maintenance will help to identify molecules that could be targeted for the treatment of immunological diseases that are characterized by insufficient or excessive Ab responses.

507 citations

Journal ArticleDOI
TL;DR: This article investigated the relationship between employees' perceptions of organisational culture and subculture, and job satisfaction and commitment, and found that ward culture was more predictive of commitment than was hospital culture.
Abstract: Investigates the relationships between employees’ perceptions of organisational culture and subculture, and job satisfaction and commitment. Questionnaires containing the above measures were distributed to nurses employed in seven large hospitals and a total of 251 responses were obtained. Measures of leadership style and employee demographics were also included in the questionnaire. Regression analysis was used to investigate the extent to which nurses’ job satisfaction and commitment to their wards are predicted by their perceptions of the hospitals’ cultures (or organisational culture), the cultures of their wards (or organisation subculture), the leadership styles of their ward managers, and several demographic characteristics including age, experience, education and job tenure. It was found that ward culture was more predictive of commitment than was hospital culture. Also, statistically controlling for job satisfaction did not substantially reduce the influence on commitment of any of the independent variables included in this study. The results suggest that managers may need to focus more on organizational subcultures in generating greater commitment among employees.

506 citations

Journal ArticleDOI
Katherine Amps1, Peter W. Andrews1, George Anyfantis2, Lyle Armstrong2, Stuart Avery3, Hossein Baharvand4, Julie C. Baker5, Duncan Baker6, Maria D. Barbadillo Muñoz7, Stephen J. Beil8, Nissim Benvenisty9, Dalit Ben-Yosef10, Juan Carlos Biancotti11, Alexis Bosman12, Romulo M. Brena8, Daniel R. Brison13, Gunilla Caisander, Marãa V. Camarasa14, Jieming Chen15, Eric Chiao5, Young Min Choi16, Andre Choo, D.M. Collins, Alan Colman3, Jeremy M. Crook3, George Q. Daley17, Anne Dalton6, Paul A. De Sousa18, Chris Denning7, J.M. Downie, Petr Dvorak19, Karen Dyer Montgomery20, Anis Feki, Angela Ford1, Victoria Fox8, Ana Maria Fraga21, Tzvia Frumkin10, Lin Ge22, Paul J. Gokhale1, Tamar Golan-Lev9, Hamid Gourabi4, Michal Gropp, Lu GuangXiu22, Aleš Hampl19, Katie Harron23, Lyn Healy, Wishva Herath15, Frida Holm24, Outi Hovatta24, Johan Hyllner, Maneesha S. Inamdar25, Astrid K. Irwanto15, Tetsuya Ishii26, Marisa Jaconi12, Ying Jin27, Susan J. Kimber14, Sergey Kiselev28, Barbara B. Knowles3, Oded Kopper9, Valeri Kukharenko, Anver Kuliev, Maria A. Lagarkova29, Peter W. Laird8, Majlinda Lako2, Andrew L. Laslett, Neta Lavon11, Dong Ryul Lee, Jeoung Eun Lee, Chunliang Li27, Linda S. Lim15, Tenneille Ludwig20, Yu Ma27, Edna Maltby6, Ileana Mateizel30, Yoav Mayshar9, Maria Mileikovsky, Stephen L. Minger31, Takamichi Miyazaki26, Shin Yong Moon16, Harry Moore1, Christine L. Mummery32, Andras Nagy, Norio Nakatsuji26, Kavita Narwani11, Steve Oh, Sun Kyung Oh16, Cia Olson33, Timo Otonkoski33, Fei Pan8, In-Hyun Park34, Steve Pells18, Martin F. Pera8, Lygia da Veiga Pereira21, Ouyang Qi22, Grace Selva Raj3, Benjamin Reubinoff, Alan Robins, Paul Robson15, Janet Rossant35, Ghasem Hosseini Salekdeh4, Thomas C. Schulz, Karen Sermon30, Jameelah Sheik Mohamed15, Hui Shen8, Eric S Sherrer, Kuldip S. Sidhu36, Shirani Sivarajah3, Heli Skottman37, Claudia Spits30, Glyn Stacey, Raimund Strehl, Nick Strelchenko, Hirofumi Suemori26, Bowen Sun27, Riitta Suuronen37, Kazutoshi Takahashi26, Timo Tuuri33, Parvathy Venu25, Yuri Verlinsky, Dorien Ward-van Oostwaard32, Daniel J. Weisenberger8, Yue Wu31, Shinya Yamanaka26, Lorraine E. Young7, Qi Zhou38 
TL;DR: Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells, and single-nucleotide polymorphism analysis revealed that they included representatives of most major ethnic groups.
Abstract: The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for genetic changes occurring during culture. Most lines were analyzed at an early and late passage. Single-nucleotide polymorphism (SNP) analysis revealed that they included representatives of most major ethnic groups. Most lines remained karyotypically normal, but there was a progressive tendency to acquire changes on prolonged culture, commonly affecting chromosomes 1, 12, 17 and 20. DNA methylation patterns changed haphazardly with no link to time in culture. Structural variants, determined from the SNP arrays, also appeared sporadically. No common variants related to culture were observed on chromosomes 1, 12 and 17, but a minimal amplicon in chromosome 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% of the lines. Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells.

506 citations

Journal ArticleDOI
TL;DR: An ultralow density (1.4 g cm(-3)) Mg-Li-based alloy is designed that is strong, ductile, and more corrosion resistant than M g-based alloys reported so far.
Abstract: Ultra-lightweight alloys with high strength, ductility and corrosion resistance are desirable for applications in the automotive, aerospace, defence, biomedical, sporting and electronic goods sectors. Ductility and corrosion resistance are generally inversely correlated with strength, making it difficult to optimize all three simultaneously. Here we design an ultralow density (1.4 g cm−3) Mg–Li-based alloy that is strong, ductile, and more corrosion resistant than Mg-based alloys reported so far. The alloy is Li-rich and a solute nanostructure within a body-centred cubic matrix is achieved by a series of extrusion, heat-treatment and rolling processes. Corrosion resistance from the environment is believed to occur by a uniform lithium carbonate film in which surface coverage is much greater than in traditional hexagonal close-packed Mg-based alloys, explaining the superior corrosion resistance of the alloy. A magnesium-based alloy with large lithium content demonstrates high specific strength in combination with corrosion resistance, associated with the formation of a lithium carbonate surface film that protects the alloy from its environment.

504 citations

Journal ArticleDOI
TL;DR: The pancreatic stellate cells are now established as key cells in fibrogenesis, particularly when activated either directly by toxic factors associated with pancreatitis or by cytokines released during pancreatic necroinflammation.

504 citations


Authors

Showing all 51897 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Nicholas G. Martin1921770161952
John C. Morris1831441168413
Richard S. Ellis169882136011
Ian J. Deary1661795114161
Nicholas J. Talley158157190197
Wolfgang Wagner1562342123391
Bruce D. Walker15577986020
Xiang Zhang1541733117576
Ian Smail15189583777
Rui Zhang1512625107917
Marvin Johnson1491827119520
John R. Hodges14981282709
Amartya Sen149689141907
J. Fraser Stoddart147123996083
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023389
20221,183
202111,342
202011,235
20199,891
20189,145