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Institution

University of New South Wales

EducationSydney, New South Wales, Australia
About: University of New South Wales is a education organization based out in Sydney, New South Wales, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 51197 authors who have published 153634 publications receiving 4880608 citations. The organization is also known as: UNSW & UNSW Australia.


Papers
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Journal ArticleDOI
TL;DR: The EPIC array is a significant improvement over the HM450 array, with increased genome coverage of regulatory regions and high reproducibility and reliability, providing a valuable tool for high-throughput human methylome analyses from diverse clinical samples.
Abstract: In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements. Illumina have now released the MethylationEPIC (EPIC) BeadChip, with new content specifically designed to target these regions. We have used HM450 and whole-genome bisulphite sequencing (WGBS) to perform a critical evaluation of the new EPIC array platform. EPIC covers over 850,000 CpG sites, including >90 % of the CpGs from the HM450 and an additional 413,743 CpGs. Even though the additional probes improve the coverage of regulatory elements, including 58 % of FANTOM5 enhancers, only 7 % distal and 27 % proximal ENCODE regulatory elements are represented. Detailed comparisons of regulatory elements from EPIC and WGBS show that a single EPIC probe is not always informative for those distal regulatory elements showing variable methylation across the region. However, overall data from the EPIC array at single loci are highly reproducible across technical and biological replicates and demonstrate high correlation with HM450 and WGBS data. We show that the HM450 and EPIC arrays distinguish differentially methylated probes, but the absolute agreement depends on the threshold set for each platform. Finally, we provide an annotated list of probes whose signal could be affected by cross-hybridisation or underlying genetic variation. The EPIC array is a significant improvement over the HM450 array, with increased genome coverage of regulatory regions and high reproducibility and reliability, providing a valuable tool for high-throughput human methylome analyses from diverse clinical samples.

825 citations

Journal ArticleDOI
TL;DR: In this article, the authors examined the relationship between audit quality and long audit partner tenure and found a lower propensity to issue a going-concern opinion and some evidence of just beating (missing) earnings benchmarks.
Abstract: Rotation of audit partners is one of the main policy initiatives that has been implemented in many jurisdictions around the world to deal with concerns about audit quality. The basis of any requirement limiting the tenure of audit partners is that there is a reduction in audit quality associated with long periods of tenure. Using data from Australia, where the audit partner can be identified and for a period where partner rotation was not mandatory, we examine the association between audit quality and long audit partner tenure. The three measures of audit quality examined are the auditor's propensity to issue a going‐concern audit opinion for distressed companies, the direction and amount of abnormal working capital accruals, and just beating (missing) earnings benchmarks. For long tenure observations we find a lower propensity to issue a going‐concern opinion and some evidence of just beating (missing) earnings benchmarks, consistent with deterioration in audit quality associated with long audit partner ...

824 citations

Journal ArticleDOI
TL;DR: This work improves the basic formulation of cooperative PSO by introducing stochastic repulsion among the particles and simultaneously scheduling all DER schedules, to investigate the potential consumer value added by coordinated DER scheduling.
Abstract: We describe algorithmic enhancements to a decision-support tool that residential consumers can utilize to optimize their acquisition of electrical energy services. The decision-support tool optimizes energy services provision by enabling end users to first assign values to desired energy services, and then scheduling their available distributed energy resources (DER) to maximize net benefits. We chose particle swarm optimization (PSO) to solve the corresponding optimization problem because of its straightforward implementation and demonstrated ability to generate near-optimal schedules within manageable computation times. We improve the basic formulation of cooperative PSO by introducing stochastic repulsion among the particles. The improved DER schedules are then used to investigate the potential consumer value added by coordinated DER scheduling. This is computed by comparing the end-user costs obtained with the enhanced algorithm simultaneously scheduling all DER, against the costs when each DER schedule is solved separately. This comparison enables the end users to determine whether their mix of energy service needs, available DER and electricity tariff arrangements might warrant solving the more complex coordinated scheduling problem, or instead, decomposing the problem into multiple simpler optimizations.

824 citations

Journal ArticleDOI
TL;DR: In this article, a number of inequalities which improve on existing upper limits to the probability distribution of the sum of independent random variables are presented, which are applicable when the number of component random variables is small and/or have different distributions.
Abstract: This paper proves a number of inequalities which improve on existing upper limits to the probability distribution of the sum of independent random variables. The inequalities presented require knowledge only of the variance of the sum and the means and bounds of the component random variables. They are applicable when the number of component random variables is small and/or have different distributions. Figures show the improvement on existing inequalities.

823 citations

Journal ArticleDOI
TL;DR: The Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients, and makes recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.
Abstract: Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of >90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD.

822 citations


Authors

Showing all 51897 results

NameH-indexPapersCitations
Ronald C. Kessler2741332328983
Nicholas G. Martin1921770161952
John C. Morris1831441168413
Richard S. Ellis169882136011
Ian J. Deary1661795114161
Nicholas J. Talley158157190197
Wolfgang Wagner1562342123391
Bruce D. Walker15577986020
Xiang Zhang1541733117576
Ian Smail15189583777
Rui Zhang1512625107917
Marvin Johnson1491827119520
John R. Hodges14981282709
Amartya Sen149689141907
J. Fraser Stoddart147123996083
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023389
20221,183
202111,342
202011,235
20199,891
20189,145