Showing papers by "University of Nice Sophia Antipolis published in 2020"
TL;DR: Chiral hybrid organic-inorganic perovskites (HOIPs) as discussed by the authors are a promising material for chiroptoelectronics, spintronics and ferroelectrics.
Abstract: Hybrid organic–inorganic perovskites (HOIPs) offer long carrier-diffusion lengths, high absorption coefficients, tunable band gaps and long spin lifetimes. The flexible crystal structure and ionic nature of HOIPs make it possible to allow tuning of their material properties through rational design, including the incorporation of chiral organic ligands. Recently, chiral HOIPs have emerged as promising materials for chiroptoelectronics, spintronics and ferroelectrics. They exhibit high photoluminescence polarization (17% without an external magnetic field), good device performance (a circularly polarized photodetector had 100 times higher responsivity than one based on a chiral metasurface) and high saturated polarization (~2 times higher than that of barium titanate). Here, we review the latest advances in chiral HOIPs and investigate the specific benefits of combining chiral organic and inorganic components in perovskites. We discuss demonstrations of chiroptical and ferroelectric applications, and conclude with our perspective on the future opportunities for chiral HOIPs. Chiral hybrid organic–inorganic perovskites combine the remarkable optical, electrical and spintronic properties of perovskites with chirality. This Review systematically introduces the latest advances in chiral perovskites, surveys their structure–property relationships and details their chiroptical and ferroelectric applications.
325 citations
University of Paris1, University of Burgundy2, University of Bordeaux3, University of Nice Sophia Antipolis4, François Rabelais University5, University of Montpellier6, University of Poitiers7, Centre national de la recherche scientifique8, Centre Hospitalier Universitaire de Grenoble9, University of Rouen10, Paris-Sorbonne University11
TL;DR: A marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19, and health authorities should be aware of these findings, in order to adapt their message if the CO VID-19 pandemic persists or recurs, or in case of future major epidemics.
Abstract: Background: The COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic.
Methods: In this registry study, we collected data from 21 centres participating in the ongoing French Cohort of Myocardial Infarction Evaluation (FRENCHIE) registry, which collects data from all patients admitted for ST segment elevation myocardial infarction (STEMI) or non-ST segment elevation myocardial infarction (NSTEMI) within 48 h of symptom onset. We analysed weekly hospital admissions over 8 weeks: the 4 weeks preceding the institution of the lockdown and the 4 weeks following lockdown. The primary outcome was the change in the number of hospital admissions for all types of acute myocardial infarction, NSTEMI, and STEMI between the 4 weeks before lockdown and the 4 weeks after lockdown. Comparisons between categorical variables were made using χ2 tests or Fisher's exact tests. Comparisons of continuous variables were made using Student's t tests or Mann-Whitney tests. Poisson regression was used to determine the significance of change in hospital admissions over the two periods, after verifying the absence of overdispersion. Age category, region, and type of acute myocardial infarction (STEMI or NSTEMI) were used as covariables. The FRENCHIE cohort is registered with ClinicalTrials.gov, NCT04050956.
Findings: Between Feb 17 and April 12, 2020, 1167 patients were consecutively admitted within 48 h of acute myocardial infarction (583 with STEMI, 584 with NSTEMI) and were included in the study. Admissions for acute myocardial infarction decreased between the periods before and after lockdown was instituted, from 686 before to 481 after lockdown (30% decrease; incidence rate ratio 0·69 [95% CI 0·51-0·70]). Admissions for STEMI decreased from 331 to 252 (24%; 0·72 [0·62-0·85]), and admissions for NSTEMI decreased from 355 to 229 (35%; 0·64 [0·55-0·76]) following institution of the lockdown, with similar trends according to sex, risk factors, and regional prevalence of hospital admissions for COVID-19.
Interpretation: A marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19. Health authorities should be aware of these findings, in order to adapt their message if the COVID-19 pandemic persists or recurs, or in case of future major epidemics.
148 citations
TL;DR: It is hypothesized that factors related to ethnicity, environment, behaviors, associated illness, and medications involving this complex system are probably responsible for situations regarded as anomalous from both an epidemiological and a clinical point of view, but, taken together, such factors may explain most of the aspects of current outbreak.
113 citations
Icahn School of Medicine at Mount Sinai1, University of Amsterdam2, University of Calgary3, Medical University of Vienna4, Catholic University of the Sacred Heart5, University of Oxford6, University of Nice Sophia Antipolis7, Katholieke Universiteit Leuven8, University of Zurich9, Humanitas University10, Ministry of Interior (Bahrain)11, university of lille12, Grigore T. Popa University of Medicine and Pharmacy13, Carol Davila University of Medicine and Pharmacy14, Military Medical Academy15, University of Kiel16, Uppsala University Hospital17, Örebro University18, AbbVie19
TL;DR: Induction of deep remission in early, moderate to severe CD with decreased risk of disease progression over a median time of 3 years, regardless of tight control or conventional management strategy.
108 citations
TL;DR: The aim of this review is to assess the effects of polyphenols on COVID-19 drug targets as well as to provide a perspective on the possibility to usepolyphenols in the development of natural approaches against this viral disease.
Abstract: The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. Polyphenols, a major class of bioactive compounds in nature, are known for their antiviral activity and pleiotropic effects. The aim of this review is to assess the effects of polyphenols on COVID-19 drug targets as well as to provide a perspective on the possibility to use polyphenols in the development of natural approaches against this viral disease.
103 citations
TL;DR: Hydroxychloroquine and azithromycin, alone or in combination, have been proposed for treatment of patients with coronavirus disease 2019 (COVID-19), but their potential cardiovascular toxicities had limited consideration in this new clinical environment.
Abstract: Keywords: azithromycin;cardiotoxicity;hydroxychloroquine;phamacovigilance EN azithromycin cardiotoxicity hydroxychloroquine phamacovigilance 303 305 3 07/23/20 20200721 NES 200721 Although hydroxychloroquine and azithromycin, alone or in combination, have been proposed for treatment of patients with coronavirus disease 2019 (COVID-19),[1] their potential cardiovascular toxicities had limited consideration in this new clinical environment The proportion that resulted in death for TdP/VT cases was 8 4% (7/83) with hydroxychloroquine and 20 2% (52/257) with azithromycin versus 0% (0/53) and 5 4% (12/223) for LQT without TdP/VT with hydroxychloroquine and azithromycin, respectively ( I P i 0 001 for both) [Extracted from the article] Copyright of Circulation is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )
86 citations
TL;DR: The results challenge the common practice of treating enhancers and silencers as separate classes of regulatory elements and suggest the possibility that thousands or more bifunctional CRMs remain to be discovered in Drosophila and 104-105 in humans.
74 citations
TL;DR: The primary objective was to test the diagnostic performance of CTC detection using the ISET technique in lung cancer screening, compared with cancers diagnosed by final pathology, or follow up if pathology was unavailable as the gold standard.
68 citations
Max Planck Society1, Hacettepe University2, Sapienza University of Rome3, New York University4, Koç University5, University of Edinburgh6, Azerbaijan National Academy of Sciences7, University of Pennsylvania8, University of Oxford9, Mustafa Kemal University10, University of Nice Sophia Antipolis11, University of Adelaide12, Harvard University13, Seoul National University14, Ludwig Maximilian University of Munich15
TL;DR: It is found that 6th millennium BCE populations of North/Central Anat Turkey and the Southern Caucasus shared mixed ancestry on a genetic cline that formed during the Neolithic between Western Anatolia and regions in today's Southern Caucasus/Zagros.
66 citations
01 Jan 2020
TL;DR: In this article, the authors discuss the compatibility of the observed properties of the Kuiper belt objects with the streaming instability paradigm and discuss how the dynamical structure of KBO population, including the formation of its five subcomponents (cold, hot, resonant, scattered, and fossilized), can be quantitatively understood in the framework of the giant planet instability.
Abstract: This chapter reviews accretion models for Kuiper belt objects (KBOs), discussing in particular the compatibility of the observed properties of the KBO population with the streaming instability paradigm. Then it discusses how the dynamical structure of the KBO population, including the formation of its five subcomponents (cold, hot, resonant, scattered, and fossilized), can be quantitatively understood in the framework of the giant planet instability. We also establish the connections between the KBO population and the Trojans of Jupiter and Neptune, the irregular satellites of all giant planets, the Oort cloud and the D-type main belt asteroids. Finally, we discuss the collisional evolution of the KBO population, arguing that the current size-frequency distribution below 100 km in size has been achieved as a collisional equilibrium in a few tens of Myr inside the original massive Trans-Neptunian disk, possibly with the exception of the cold population subcomponent.
64 citations
TL;DR: A marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19, in order to adapt their message in case of a second wave of the pandemic or future major epidemics.
Abstract: Aim: to evaluate the impact of a nationwide lockdown in France on acute myocardial infarction (AMI) admissions, by patient characteristics and regional prevalence of the pandemic.
Methods and Results: We collected data from 21 centres participating in the on-going FRENCHIE registry (NCT04050956), which collects data from all patients admitted for STEMI or NSTEMI within 48 hours of symptom onset. We compared weekly admissions in the 4 weeks preceding and the 4 weeks following institution of the lockdown. We observed a brutal 30% decrease in AMI admissions (24% for STEMI and 36% for NSTEMI, P=0.14) following institution of the lockdown, with similar trends according to gender (30% decrease in both men and women), risk factors, and regional prevalence of COVID-19. The decrease was numerically greater in patients aged 80 years or more (44% vs 27%, P=0.10). Patient characteristics, including time to hospital admission in STEMI patients, did not differ between the 2 periods. In-hospital mortality was numerically higher following institution of the lockdown (5.2% vs 3.4%, P=0.12), with similar trends for STEMI and NSTEMI.
Conclusion: A marked decrease in hospital admissions was observed following the lockdown, irrespective of patient characteristics and regional prevalence of COVID-19. Health authorities should be aware of these findings, in order to adapt their message in case of a second wave of the pandemic or future major epidemics.
Funding Statement: The FRENCHIE registry is supported by Recherche Hospitalo-universitaire en sante (RHU) iVasc within the programme "Investissements d'avenir", and sponsored by Assistance Publique – Hopitaux de Paris (Delegation a la Recherche Clinique et a l'Innovation).
Declaration of Interests: YC reports research Grants to the Institution or Consulting/Lecture Fees from : Novartis , Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Sanofi-Aventis, outside the submitted work. P. Coste reports having received fees from Amgen, AstraZeneca, Bayer and Servier, outside the submitted work G. Lemesle reports personal fees from Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, BristolMyers Squibb, MSD, Novartis, Pfizer, Sanofi-Aventis, Servier, and The Medicine Co, outside the submitted work. FS reports personal fees from Amgen, Astra Zeneca, Bayer, BMS, MSD, Pfizer, and Sanofi, outside the submitted work D. Angoulvant reports receiving consulting and lecture fees from AstraZeneca, Bayer, Bristol-Myers Squibb/Pfizer, Sanofi, Amgen, Novartis, Novo-Nordisk, Servier and MSD, outside the submitted work C. Bouleti reports receiving consulting and lecture fees from Novartis and AstraZeneca, outside the submitted work. G. Cayla has received research grants/consultant fees/lectures fees from Amgen, AstraZeneca, Abbott, Bayer, Biotronik, Bristol-Myers Squibb, Pfizer, Sanofi-Aventis, outside the submitted work. P. Goube reports receiving consulting and lecture fees from AMGEN, SANOFI, BMS, ABBOT, outside the submitted work. T. Lhermusier has received research grants/consultant fees/lectures fees from AstraZeneca, Boston scientifics and Abbott, outside the submitted work A. Saib reports lectures fees from Novartis, outside the submitted work JG Dillinger reports receiving consulting and lecture fees from AstraZeneca, Bayer, BoehringerIngelheim, Bristol-Myers Squibb/Pfizer, Sanofi, and Daiichi-Sankyo and grants from Bayer, BristolMyers Squibb/Pfizer and Biosensors, outside the submitted work. F. Boccara reports research grants from Amgen; lecture fees from Janssen, Gilead, ViiV Healthcare, Amgen, Sanofi, MSD, and Servier outside the submitted work. And personal consultant or lecture fees from Amgen, AstraZeneca, Bayer, BMS, Boehringer Ingelheim, Intercept, MSD, Novartis, Pfizer, Sanofi, and Servier, outside the submitted work. T. Simon reports grants from Astrazeneca, Daiichi-Sankyo, Eli-Lilly, GSK, MSD, Novartis, Sanofi, and personal fees for board membership and/or consultancy and/or lectures from AstraZeneca, BMS, Sanofi, and Novartis, outside the submitted work. N. Danchin has received research grants, or speaking and consulting fees from Amgen, AstraZeneca, BMS, Boehringer Ingelheim, Eli-Lilly, Intercept, MSD, Novartis, Novo-Nordisk, Pfizer, Sanofi, Servier, outside the submitted work. The other authors have nothing to report.
Ethics Approval Statement: FRENCHIE has been approved by the Comite de Protection des Personnes and by the French data regulatory authority (Commission Nationale de l'Informatique et des Libertes).
TL;DR: This work used an integrated transcriptomic, proteomic, and structural biology approach to demonstrate that the lethal Australian funnel-web spider produces 33 superfamilies of venom peptides and proteins, and revealed that most of these disulfide-rich peptides are structurally related and range in complexity from simple to highly elaborated knottin domains.
Abstract: Spiders are one of the most successful venomous animals, with more than 48,000 described species. Most spider venoms are dominated by cysteine-rich peptides with a diverse range of pharmacological activities. Some spider venoms contain thousands of unique peptides, but little is known about the mechanisms used to generate such complex chemical arsenals. We used an integrated transcriptomic, proteomic, and structural biology approach to demonstrate that the lethal Australian funnel-web spider produces 33 superfamilies of venom peptides and proteins. Twenty-six of the 33 superfamilies are disulfide-rich peptides, and we show that 15 of these are knottins that contribute >90% of the venom proteome. NMR analyses revealed that most of these disulfide-rich peptides are structurally related and range in complexity from simple to highly elaborated knottin domains, as well as double-knot toxins, that likely evolved from a single ancestral toxin gene.
INAF1, University of Florence2, Monash University3, University of Hertfordshire4, Lund University5, Diego Portales University6, University of Cambridge7, Vilnius University8, University of Pisa9, University of Porto10, University of New South Wales11, Valparaiso University12, Keele University13, Spanish National Research Council14, Carnegie Mellon University15, Uppsala University16, University of Nice Sophia Antipolis17, Polish Academy of Sciences18, Andrés Bello National University19
TL;DR: In this article, the authors analyzed high-resolution and high-signal-to-noise-ratio HARPS spectra of a sample of solar-like stars to obtain precise determinations of their atmospheric parameters and abundances for 25 elements and ions belonging to the main nucleosynthesis channels.
Abstract: Context. In the era of large spectroscopic surveys, massive databases of high-quality spectra coupled with the products of the Gaia satellite provide tools to outline a new picture of our Galaxy. In this framework, an important piece of information is provided by our ability to infer stellar ages, and consequently to sketch a Galactic timeline.Aims. We aim to provide empirical relations between stellar ages and abundance ratios for a sample of stars with very similar stellar parameters to those of the Sun, namely the so-called solar-like stars. We investigate the dependence on metallicity, and we apply our relations to independent samples, that is, the Gaia -ESO samples of open clusters and of field stars.Methods. We analyse high-resolution and high-signal-to-noise-ratio HARPS spectra of a sample of solar-like stars to obtain precise determinations of their atmospheric parameters and abundances for 25 elements and/or ions belonging to the main nucleosynthesis channels through differential spectral analysis, and of their ages through isochrone fitting.Results. We investigate the relations between stellar ages and several abundance ratios. For the abundance ratios with a steeper dependence on age, we perform multivariate linear regressions, in which we include the dependence on metallicity, [Fe/H]. We apply our best relations to a sample of open clusters located from the inner to the outer regions of the Galactic disc. Using our relations, we are able to recover the literature ages only for clusters located at R GC > 7 kpc. The values that we obtain for the ages of the inner-disc clusters are much greater than the literature ones. In these clusters, the content of neutron capture elements, such as Y and Zr, is indeed lower than expected from chemical evolution models, and consequently their [Y/Mg] and [Y/Al] are lower than in clusters of the same age located in the solar neighbourhood. With our chemical evolution model and a set of empirical yields, we suggest that a strong dependence on the star formation history and metallicity-dependent stellar yields of s -process elements can substantially modify the slope of the [s /α ]–[Fe/H]–age relation in different regions of the Galaxy.Conclusions. Our results point towards a non-universal relation [s /α ]–[Fe/H]–age, indicating the existence of relations with different slopes and intercepts at different Galactocentric distances or for different star formation histories. Therefore, relations between ages and abundance ratios obtained from samples of stars located in a limited region of the Galaxy cannot be translated into general relations valid for the whole disc. A better understanding of the s -process at high metallicity is necessary to fully understand the origin of these variations.
TL;DR: Biliary reflux although rare can complicate OAGB and RYGB is a safe and feasible technique of revision in this case, and a shorter length of the afferent limb during the initial operation facilitates the revision.
Abstract: Biliary reflux resistant to medical treatment has an incidence of 0.6–10% after one anastomosis gastric bypass (OAGB) and may be a reason for revisional surgery. The aim of this study is to report the results of a single-institution series of patients who underwent conversion from OAGB to Roux-en-Y gastric bypass (RYGB) for biliary reflux. Data of OAGB patients converted to RYGB between May 2010 and December 2017 were prospectively collected and retrospectively analyzed. The afferent limb was sectioned proximally to the gastrojejunal anastomosis. A jejuno-jejunal latero-lateral anastomosis was performed between the biliary and alimentary limb. The final RYGB had an alimentary limb of 100 cm and a biliary limb of 150 cm. During the study period, 2780 patients underwent OAGB. A total of 32 patients (1.2%) underwent conversion from OAGB to RYGB for biliary reflux, at a mean of 30.3 months from OAGB. Mean weight before RYGB was 70.6 kg, and mean body mass index BMI was 26 kg/m2. Four patients experienced postoperative complications (12.5%). Patients’ mean weight was 74.3 kg at 24 months follow-up, with BMI of 27.2 kg/m2. Conversion to RYGB relieved symptoms of biliary reflux in all patients but 2 (93.8%). Biliary reflux although rare can complicate OAGB. RYGB is a safe and feasible technique of revision in this case. A shorter length of the afferent limb during the initial operation facilitates the revision.
TL;DR: In this article, a number of non-ionic eutectic solvents (HESs) liquid at room temperature were identified from a large initial screening of potential mixtures, and three new HESs based on thymol + TOPO (trioctylphosphine oxide), TOPO + capric acid, and hydrocinnamic acid+capric acid were investigated as extracting media for the recovery and separation of platinum group and transition metals in HCl media.
Leibniz Institute for Astrophysics Potsdam1, University of Strasbourg2, Max Planck Society3, École Polytechnique Fédérale de Lausanne4, University of Victoria5, University of Cambridge6, University of Toronto7, Spanish National Research Council8, University of La Laguna9, University of Nice Sophia Antipolis10, University of Paris11, Stockholm University12, UK Astronomy Technology Centre13, Kapteyn Astronomical Institute14, University of St Andrews15
TL;DR: In this article, the authors used the Pristine and LAMOST surveys and Gaia DR2 parallaxes and proper motions for an unprecedented large and unbiased sample of 1027 very metal poor stars at [Fe/H] ≤ -2.5 dex, and they showed strong statistical evidence (at the 5.0σ level) of asymmetry in their kinematics, favoring prograde motion.
Abstract: The orbits of the least chemically enriched stars open a window on the formation of our Galaxy when it was still in its infancy. The common picture is that these low-metallicity stars are distributed as an isotropic, pressure-supported component since these stars were either accreted from the early building blocks of the assembling Milky Way (MW), or were later brought by the accretion of faint dwarf galaxies. Combining the metallicities and radial velocities from the Pristine and LAMOST surveys and Gaia DR2 parallaxes and proper motions for an unprecedented large and unbiased sample of 1027 very metal poor stars at [Fe/H] ≤ -2.5 dex, we show that this picture is incomplete. We find that $31{{\ \rm per\ cent}}$ of the stars that currently reside spatially in the disc ( $|Z| \le 3{\rm \, kpc}$ ) do not venture outside of the disc plane throughout their orbit. Moreover, this sample shows strong statistical evidence (at the 5.0σ level) of asymmetry in their kinematics, favouring prograde motion. The discovery of this population implies that a significant fraction of stars with iron abundances [Fe/H] ≤ -2.5 dex merged into, formed within, or formed concurrently with the MW disc and that the history of the disc was quiet enough to allow them to retain their disc-like orbital properties, challenging theoretical and cosmological models.
TL;DR: In this article, a general methodology to derive stability conditions and error estimates that are explicit with respect to the wavenumber is proposed. But the method is not suitable for the case of convected sound waves.
Abstract: We analyze the convergence of finite element discretizations of time-harmonic wave propagation problems. We propose a general methodology to derive stability conditions and error estimates that are explicit with respect to the wavenumber. This methodology is formally based on an expansion of the solution in powers of k, which permits to split the solution into a regular, but oscillating part, and another component that is rough, but behaves nicely when the wavenumber increases. The method is developed in its full generality and is illustrated by two particular cases: the elastic and convected sound waves. Numerical experiments are provided which confirm that the stability conditions and error estimates are sharp.
TL;DR: How the French Health Care system created temporary ICU beds to avoid being overwhelmed in the COVID-19 outbreak is reported, essentially by transforming beds from ACUs and PACUs.
Abstract: Background Whereas 5415 Intensive Care Unit (ICU) beds were initially available, 7148 COVID-19 patients were hospitalised in the ICU at the peak of the outbreak. The present study reports how the French Health Care system created temporary ICU beds to avoid being overwhelmed. Methods All French ICUs were contacted for answering a questionnaire focusing on the available beds and health care providers before and during the outbreak. Results Among 336 institutions with ICUs before the outbreak, 315 (94%) participated, covering 5054/5531 (91%) ICU beds. During the outbreak, 4806 new ICU beds (+95% increase) were created from Acute Care Unit (ACU, 2283), Post Anaesthetic Care Unit and Operating Theatre (PACU & OT, 1522), other units (374) or real build-up of new ICU beds (627), respectively. At the peak of the outbreak, 9860, 1982 and 3089 ICU, ACU and PACU beds were made available. Before the outbreak, 3548 physicians (2224 critical care anaesthesiologists, 898 intensivists and 275 from other specialties, 151 paediatrics), 1785 residents, 11,023 nurses and 6763 nursing auxiliaries worked in established ICUs. During the outbreak, 2524 physicians, 715 residents, 7722 nurses and 3043 nursing auxiliaries supplemented the usual staff in all ICUs. A total number of 3212 new ventilators were added to the 5997 initially available in ICU. Conclusion During the COVID-19 outbreak, the French Health Care system created 4806 ICU beds (+95% increase from baseline), essentially by transforming beds from ACUs and PACUs. Collaboration between intensivists, critical care anaesthesiologists, emergency physicians as well as the mobilisation of nursing staff were primordial in this context.
TL;DR: In this paper, the authors derived a formula that provides an upper bound to the growth of a planet as a function of time in a typical ring and a putative ring rescaled at 5 AU.
Abstract: Context. Pebble accretion is expected to be the dominant process for the formation of massive solid planets, such as the cores of giant planets and super-Earths. So far, this process has been studied under the assumption that dust coagulates and drifts throughout the full protoplanetary disk. However, observations show that many disks are structured in rings that may be due to pressure maxima, preventing the global radial drift of the dust.Aims. We aim to study how the pebble-accretion paradigm changes if the dust is confined in a ring.Methods. Our approach is mostly analytic. We derived a formula that provides an upper bound to the growth of a planet as a function of time. We also numerically implemented the analytic formulae to compute the growth of a planet located in a typical ring observed in the DSHARP survey, as well as in a putative ring rescaled at 5 AU.Results. Planet Type I migration is stopped in a ring, but not necessarily at its center. If the entropy-driven corotation torque is desaturated, the planet is located in a region with low dust density, which severely limits its accretion rate. If the planet is instead near the ring’s center, its accretion rate can be similar to the one it would have in a classic (ringless) disk of equivalent dust density. However, the growth rate of the planet is limited by the diffusion of dust in the ring, and the final planet mass is bounded by the total ring mass. The DSHARP rings are too far from the star to allow the formation of massive planets within the disk’s lifetime. However, a similar ring rescaled to 5 AU could lead to the formation of a planet incorporating the full ring mass in less than 1/2 My.Conclusions. The existence of rings may not be an obstacle to planet formation by pebble-accretion. However, for accretion to be effective, the resting position of the planet has to be relatively near the ring’s center, and the ring needs to be not too far from the central star. The formation of planets in rings can explain the existence of giant planets with core masses smaller than the so-called pebble isolation mass.
TL;DR: Lower pre-surgery Body Mass Index (BMI) and low muscle mass impact negatively long-term survival of non-small cell lung cancer (NSCLC) and strategies improving body fat and muscular mass before surgery should be considered.
Abstract: Lower pre-surgery Body Mass Index (BMI) and low muscle mass impact negatively long-term survival of non-small cell lung cancer (NSCLC). We investigated their influence on survival after major lung resection for NSCLC. Methods: A retrospective analysis of a prospectively collected database was made on 304 consecutive patients. Results: Underweight, normal, overweight and obese patients represented 7.6%, 51.6%, 28.6%, and 12.6% of the pre-disease population. Weight loss and gain were recorded in 44.4% and 5% of patients, respectively. Low muscle mass was more frequently associated with BMI 25 kg/m2, and, even more, in case of BMI > 25 kg/m2 and increasing weight (p = 0.012). Long-term outcome was negatively influenced by low muscle mass (p = 0.042) and weight loss (p = 0.0052) as well as age (p = 0.017), ASA categories (p = 0.025), extent of resection (p = 0.0001), pleural invasion (p = 0.0012) and higher pathologic stage (p < 0.0001). Three stepwise multivariable models confirmed the independent favorable prognostic value of higher pre-disease (RR 0.66[0.49–0.89], p = 0.006) and pre-surgery BMI (RR 0.72[0.54–0.98], p = 0.034), and the absence of low muscle mass (RR 0.56[0.37–0.87], p = 0.0091). Conclusions: Body reserves assessed by simple clinical markers impact survival of surgically treated NSCLC. Strategies improving body fat and muscular mass before surgery should be considered.
University of Montpellier1, University of Toulouse2, Maastricht University3, French Institute of Health and Medical Research4, Trinity College, Dublin5, King's College London6, University of Nice Sophia Antipolis7, University of Grenoble8, Charité9, Ghent University10, University of Nottingham11, University of Lorraine12
TL;DR: The EuGMS guidance enables LTCFs to adapt and suitably implement infection prevention and control measures, considering that the priorities are (1) early detection of symptomatic and asymptomatic COVID-19 residents, staff members and visitors who contribute to the entrance and dissemination of CO VID-19 infection in L TCFs and (2) to limit the negative effects of isolation in infected residents.
TL;DR: It is found that S19P and K26R were, among the most diffused SNPs worldwide, the only two SNPs that were able to potentially affect the interaction of ACE2 with SARS-CoV-2 spike.
Abstract: The current SARS covid-19 epidemic spread appears to be influenced by ethnical, geographical and sex-related factors that may involve genetic susceptibility to diseases. Similar to SARS-CoV, SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells, notably type II alveolar epithelial cells. Importantly, ACE2 gene is highly polymorphic. Here we have used in silico tools to analyze the possible impact of ACE2 single-nucleotide polymorphisms (SNPs) on the interaction with SARS-CoV-2 spike glycoprotein. We found that S19P (common in African people) and K26R (common in European people) were, among the most diffused SNPs worldwide, the only two SNPs that were able to potentially affect the interaction of ACE2 with SARS-CoV-2 spike. FireDock simulations demonstrated that while S19P may decrease, K26R might increase the ACE2 affinity for SARS-CoV-2 Spike. This finding suggests that the S19P may genetically protect, and K26R may predispose to more severe SARS-CoV-2 disease.
TL;DR: The FRIPON project as discussed by the authors is a fully automated camera and radio network deployed over a significant fraction of western Europe and a small fraction of Canada, which consists of 150 cameras and 25 European radio receivers and covers an area of about 1.5 × 106km2.
Abstract: Context. Until recently, camera networks designed for monitoring fireballs worldwide were not fully automated, implying that in case of a meteorite fall, the recovery campaign was rarely immediate. This was an important limiting factor as the most fragile - hence precious - meteorites must be recovered rapidly to avoid their alteration. Aims. The Fireball Recovery and InterPlanetary Observation Network (FRIPON) scientific project was designed to overcome this limitation. This network comprises a fully automated camera and radio network deployed over a significant fraction of western Europe and a small fraction of Canada. As of today, it consists of 150 cameras and 25 European radio receivers and covers an area of about 1.5 × 106km2. Methods. The FRIPON network, fully operational since 2018, has been monitoring meteoroid entries since 2016, thereby allowing the characterization of their dynamical and physical properties. In addition, the level of automation of the network makes it possible to trigger a meteorite recovery campaign only a few hours after it reaches the surface of the Earth. Recovery campaigns are only organized for meteorites with final masses estimated of at least 500 g, which is about one event per year in France. No recovery campaign is organized in the case of smaller final masses on the order of 50 to 100 g, which happens about three times a year; instead, the information is delivered to the local media so that it can reach the inhabitants living in the vicinity of the fall. Results. Nearly 4000 meteoroids have been detected so far and characterized by FRIPON. The distribution of their orbits appears to be bimodal, with a cometary population and a main belt population. Sporadic meteors amount to about 55% of all meteors. A first estimate of the absolute meteoroid flux (mag < -5; meteoroid size ≥∼1 cm) amounts to 1250/yr/106km2. This value is compatible with previous estimates. Finally, the first meteorite was recovered in Italy (Cavezzo, January 2020) thanks to the PRISMA network, a component of the FRIPON science project.
TL;DR: In this article, a series of impact simulations were performed to quantify the f-value, followed by a Monte Carlo procedure enacting a monotonically decaying impact flux, to compute the mass accreted into lunar crust and mantle over their histories.
Abstract: The importance of highly siderophile elements (HSEs) to track planetary late accretion has long been recognized. However, the precise nature of the Moon's accretional history remains enigmatic. There exists a significant mismatch of HSE budgets between the Earth and Moon, with the Earth disproportionally accreted far more HSEs than the Moon did. Several scenarios have been proposed to explain this conundrum, including the delivery of HSEs to Earth by a few big impactors, the accretion of pebble-sized objects on dynamically cold orbits that enhanced the Earth's gravitational focusing factor, and the "sawtooth model" with much reduced impact flux before ~4.10 Gyr. However, most of these models assume a high impactor retention ratio f (fraction of impactor mass retained on the target) for the Moon. Here, we performed a series of impact simulations to quantify the f-value, followed by a Monte Carlo procedure enacting a monotonically decaying impact flux, to compute the mass accreted into lunar crust and mantle over their histories. We found that the average f-value for the Moon's entire impact history is about 3 times lower than previously estimated. Our results indicate that, to match the HSE budget of lunar crust and mantle, the retention of HSEs should have started ~ 4.35 Gyr ago, when most of lunar magma ocean was solidified. Mass accreted prior to 4.35 Gyr must have lost its HSE to the lunar core, presumably during the lunar mantle crystallization. The combination of a low impactor retention ratio and a late retention of HSEs in the lunar mantle provide a realistic explanation for the apparent deficit of Moon's late accreted mass relative to the Earth.
TL;DR: In this paper, the formation of a first generation of planetesimals during the condensation of refractory elements implies the subsequent formation of residual condensates with strongly sub-solar Al/Si and Mg/Si ratios.
TL;DR: In this article, the authors examined the financialization of housing and land and illustrated how these processes are intertwined and reinforce each other by studying the case of China's state land ownership regime.
TL;DR: In this article, the authors discuss the flaws of those papers that invalidate the authors' conclusions and identify in the Halley-type comets and the Oort cloud the most likely sources of retrograde co-orbitals and highly inclined Centaurs.
Abstract: In two recent papers published in MNRAS, Namouni and Morais claimed evidence for the interstellar origin of some small Solar system bodies, including: (i) objects in retrograde co-orbital motion with the giant planets and (ii) the highly inclined Centaurs. Here, we discuss the flaws of those papers that invalidate the authors’ conclusions. Numerical simulations backwards in time are not representative of the past evolution of real bodies. Instead, these simulations are only useful as a means to quantify the short dynamical lifetime of the considered bodies and the fast decay of their population. In light of this fast decay, if the observed bodies were the survivors of populations of objects captured from interstellar space in the early Solar system, these populations should have been implausibly large (e.g. about 10 times the current main asteroid belt population for the retrograde co-orbital of Jupiter). More likely, the observed objects are just transient members of a population that is maintained in quasi-steady state by a continuous flux of objects from some parent reservoir in the distant Solar system. We identify in the Halley-type comets and the Oort cloud the most likely sources of retrograde co-orbitals and highly inclined Centaurs.
TL;DR: In this paper, the authors study how the pebble-accretion paradigm changes if the dust is confined in a ring, but not necessarily at its center, and they show that if the planet is near the ring's center, its accretion rate can be similar to the one it would have in a classic (ring-less) disk of equivalent dust density.
Abstract: Context: Pebble accretion is expected to be the dominant process for the formation of massive solid planets, such as the cores of giant planets and super-Earths. So, far, this process has been studied under the assumption that dust coagulates and drifts throughout the full protoplanetary disk. However, observations show that many disks are structured in rings that may be due to pressure maxima, preventing the global radial drift of the dust.
Aims: We study how the pebble-accretion paradigm changes if the dust is confined in a ring.
Results: Planet Type-I migration is stopped in a ring, but not necessarily at its center. If the entropy-driven corotation torque is desaturated, the planet is located in a region with a low density of dust, which severely limits its accretion rate. If instead the planet is near the ring's center, its accretion rate can be similar to the one it would have in a classic (ring-less) disk of equivalent dust density. However, the growth rate of the planet is limited by the diffusion of dust in the ring and the final planet's mass is bounded by the total ring's mass. The DSHARP rings are too far from the star to allow the formation of massive planets within the disk's lifetime. However, a similar ring rescaled to 5 AU could lead to the formation of a planet incorporating the full ring's mass in less than 1/2 My.
Conclusions: The existence of rings may not be an obstacle to planet formation by pebble-accretion. However, for accretion to be effective the resting position of the planet has to be relatively near the ring's center and the ring needs to be not too far from the central star. The formation of planets in rings can explain the existence of giant planets with core masses smaller than the so-called pebble isolation mass.
TL;DR: Comparative trials remain necessary between N-Sleeve and standard bariatric procedures to refine the specific indications of each of them and determine the eventual role of the N- Sleeve.
Abstract: The Montpellier bariatric team has recently proposed some technical alternatives to decrease the rate of gastroesophageal reflux disease (GERD) after bariatric surgery and also to offer patients an alternative in case of contraindication to Roux-en-Y gastric bypass (RYGBP): the Nissen-Sleeve (N-Sleeve). We present here the results from a cohort of patients that underwent an operation with this newly designed anti-reflux bariatric procedure N-Sleeve: Nissen valve added to a standard SG. Data from a prospective, observational, and monocentric cohort. All consecutive patients presenting to the bariatric surgery department for a laparoscopic sleeve gastrectomy between 2016 and 2018 with GERD were included in the study. The fundus was stapled with a margin from the valve, and the valve was created with tissue at a distance from the greater curvature so as to avoid a double layer stapling of the stomach. A total of 70 patients were included in the study. Ninety percent of the cohort presented with a hiatal hernia at the time of surgery. No mortality was observed during the follow-up period. Concerning GERD, 76% of all patients had preoperative esophageal syndromes, whereas 21% were asymptomatic with associated esophagitis. Grade A–C esophagitis was present in 99% of the cohort, but no Barrett’s esophagus was present. Fifty-six (80%) patients used PPIs regularly. At 1 year of follow-up, one patient was still symptomatic. Comparative trials remain necessary between N-Sleeve and standard bariatric procedures to refine the specific indications of each of them and determine the eventual role of the N-Sleeve.
TL;DR: mVM is a new and extensible migration scheduler that parallelizes and sequentializes the migrations with regards to the memory workload and the network topology, and its current library allows administrators to address temporal and energy concerns.
Abstract: Every day, numerous VMs are migrated inside a datacenter to balance the load, save energy or prepare production servers for maintenance. Although VM placement problems are carefully studied, the underlying migration schedulers rely on vague adhoc models. This leads to unnecessarily long and energy-intensive migrations. We present mVM, a new and extensible migration scheduler. To provide schedules with minimal completion times, mVM parallelizes and sequentializes the migrations with regards to the memory workload and the network topology. mVM is implemented as a plugin of BtrPlace and its current library allows administrators to address temporal and energy concerns. Experiments on a real testbed shows mVM outperforms state-of-the-art migration schedulers. Compared to schedulers that cap the migration parallelism, mVM reduces the individual migration duration by 20.4 percent on average and the schedule completion time by 28.1 percent. In a maintenance operation involving 96 VMs migrated between 72 servers, mVM saves 21.5 percent Joules against BtrPlace. Compared to the migration model inside the cloud simulator CloudSim, the prediction error of the migrations duration is about 5 times lower with mVM. By computing schedules involving thousands of migrations performed over various fat-tree network topologies, we observed that the mVM solving time accounts for about 1 percent of the schedule execution time.