Showing papers by "University of Nigeria, Nsukka published in 2012"

Board characteristics and the financial performance of Nigerian quoted firms

Abstract: – The purpose of this paper is to investigate the impact of corporate board characteristics on the financial performance of Nigerian quoted firms. Board characteristics studied comprise board size, board skill, board nationality, board gender, board ethnicity and CEO duality., – The study employed the random‐effects and fixed‐effects generalised least squares (GLS) regression to test the six hypotheses formulated for the study, while controlling for firm size and firm age., – Using panel data from 122 quoted firms in Nigeria between 1991 and 2008, it was found that board size, CEO duality and gender diversity were negatively linked with firm performance, whereas board nationality, board ethnicity and the number of board members with a PhD qualification were found to impact positively on firm performance. The result of the robustness test using the same board characteristics for 160 small firms showed that board duality was positively linked to firm performance, while a PhD qualification was negatively linked to firm performance., – The study contributes to the understanding of the board‐performance link by examining both the traditional variables such as board size, CEO duality and other organisational attributes such as ethnic diversity, foreign nationality and competence variables represented by women and PhD holders, respectively. The results provide an insight for practitioners and policy makers on the importance of relying on institutional specifics in the prescription of corporate governance codes., – The study adds value to the global corporate governance discourse in two ways: first, the use of Nigeria, which is claimed to have one of the weakest business cultures in the world, and secondly, using a good number of proxies that are country‐specific for corporate boards.

The metabolic syndrome in Africa: Current trends.

Abstract: Metabolic syndrome is a clustering of several cardiovascular risk factors. Contrary to earlier thoughts, metabolic syndrome is no longer rare in Africa. The prevalence is increasing, and it tends to increase with age. This increase in the prevalence of metabolic syndrome in the continent is thought to be due to departure from traditional African to western lifestyles. In Africa, it is not limited to adults but is also becoming common among the young ones. Obesity and dyslipidemia seem to be the most common occurring components. While obesity appears more common in females, hypertension tends to be more predominant in males. Insulin resistance has remained the key underlying pathophysiology. Though pharmacologic agents are available to treat the different components of the syndrome, prevention is still possible by reverting back to the traditional African way of life.

The challenge of managing electronic records in developing countries

Abstract: Purpose – Electronic records management is new to most records officers and archivists in contemporary sub Saharan Africa It transformed the traditional mode of recordkeeping and brought with it some constraints which records managers have to contend with if they are to remain relevant in the information society This paper aims to examine the background of these problems as well as the strategies for e‐records management in Africa Design/methodology/approach – Relevant literature on archives development in Africa, electronic records, information technology, and records management were reviewed and the author gathered much insight on electronic records management in a digital environment These were applied to fortify the author's arguments Findings – The study shows that the major problems of e‐records management in Africa are administrative and the technically induced challenge and the benefits of managing hybrid records in Africa can only be realized if the appropriate infrastructures, workable legislation and regulatory frameworks, adequate finance, and competent ICT personnel are available Practical implications – Introducing technological solutions to e‐records management in Africa without first addressing those necessary preconditions would increase the vulnerability of public records and jeopardize public services in the continent Originality/value – The study highlights the potential problems and provides guidelines which information professionals and stakeholders in developing countries should adopt for successful implementation of e‐records management

Profile of Nigerians with diabetes mellitus - Diabcare Nigeria study group (2008): Results of a multicenter study

Abstract: Background: Diabetes Mellitus is the commonest endocrine-metabolic disorder in Nigeria similar to the experience in other parts of the world. The aim was to assess the clinical and laboratory profile, and evaluate the quality of care of Nigerian diabetics with a view to planning improved diabetes care. Materials and Methods: In a multicenter study across seven tertiary health centers in Nigeria, the clinical and laboratory parameters of diabetic out-patients were evaluated. Clinical parameters studied include type of diabetes, anthropometry, and blood pressure (BP) status, chronic complications of diabetes, and treatment types. Laboratory data assessed included fasting plasma glucose (FPG), 2-h post-prandial (2-HrPP) glucose, glycated hemoglobin (HbA1c), urinalysis, serum lipids, electrolytes, urea, and creatinine. Results: A total of 531 patients, 209 (39.4%) males and 322 (60.6%) females enrolled. The mean age of the patients was 57.1 ± 12.3 years with the mean duration of diabetes of 8.8 ± 6.6 years. Majority (95.4%) had type 2 diabetes mellitus (DM) compared to type 1 DM (4.6%), with P < 0.001. The mean FPG, 2-HrPP glucose, and HbA1c were 8.1 ± 3.9 mmol/L, 10.6 ± 4.6 mmol/L, and 8.3 ± 2.2%, respectively. Only 170 (32.4%) and 100 (20.4%) patients achieved the ADA and IDF glycemic targets, respectively. Most patients (72.8%) did not practice self-monitoring of blood glucose. Hypertension was found in 322 (60.9%), with mean systolic BP 142.0 ± 23.7 mmHg, and mean diastolic BP 80.7 ± 12.7 mmHg. Diabetic complications found were peripheral neuropathy (59.2%), retinopathy (35.5%), cataracts (25.2%), cerebrovascular disease (4.7%), diabetic foot ulcers (16.0%), and nephropathy (3.2%). Conclusion: Most Nigerian diabetics have suboptimal glycemic control, are hypertensives, and have chronic complications of DM. Improved quality of care and treatment to target is recommended to reduce diabetes-related morbidity and mortality.

Obstructive sleep apnea hypopnea syndrome

Abstract: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an important medical condition which is on the increase in the past 50 years. It causes significant morbidity and mortality in both developed and developing nations of the world. To review the relevant literature on obstructive sleep apnea. Literature review was carried out on the pathophysiology, clinical presentation, complications, diagnostic modalities, and treatment using computerized search. Additional information was obtained by cross referencing and using texts and journals in the medical libraries of Federal Medical Centre Owerri and University of Nigeria, Enugu. Most of the literature was from developed countries, with very few reports from Africa. Comprehensive management plan was lacking in many textbooks. OSAHS is an increasing medical and, more importantly, respiratory condition across the world. Early recognition and prompt appropriate intervention measures will reduce the mortality and improve the quality of life in patients with such conditions.

Membrane stabilization as a mechanism of the anti-inflammatory activity of methanol extract of garden egg (Solanum aethiopicum)

Abstract: Some observations and reports show that people with high consumption of Solanum aethiopicum (African garden egg) have relief in arthritic pains and swelling. We aimed at assessing the effect of methanol extract of Solanum aethiopicum in experimentally induced inflammation using leukocyte mobilization and vascular permeability tests in rats and human red blood cell (HRBC) membrane stabilization as studies. Twenty five (25) adult Wistar rats of either sex (120 g – 200 g) divided into five groups of five rats each were used for each of the animal models. Groups 2, 3 and 4 were administered varied doses of the extract (100, 200 and 400 mg/kg), while groups 1 (vehicle control) and 5 (treatment control) received normal saline and indomethacin (50 mg/kg) respectively. Vascular permeability was induced by the intra-peritoneal injection of 1 ml of acetic acid and monitored using 0.5 ml intravenous injection of 1% Evans blue solution. Leukocyte mobilization was induced by the intra-peritoneal injection of 0.5 ml of 3% agar suspension in normal saline. Heat and hypotonicity induced heamolysis of HRBC membrane was used to assess membrane stabilization. The methanol extracts of garden egg significantly and dose dependently reduced (p≤0.05) the acetic acid induced vascular permeability and agar induced leukocyte mobilization in rats. The percentage inhibitions of induced vascular permeability were 21 ± 3.39, 25 ±1.92 and 60 ± 3.81 for the 100, 200 and 400 mg/kg of the extract while the inhibitions of the agar induced leucocyte migration were 23 ± 2.17, 26 ± 1.58 and 32 ± 1.58 for the 100, 200 and 400 mg/kg of the extract respectively. The extract also, at doses of 100, 200, 400, 600 and 800 μg/ml significantly inhibited heat induced lysis of the human red cell membrane with values of 66.46 ± 2.89, 65.14 ± 4.58, 46.53 ± 2.52, 61.88 ± 4.51and 86.67 ± 3.06 respectively. These results show that methanol extract of Solanum aethiopicum has anti-inflammatory properties and can reduce inflammatory injury and tissue damage.

An overview of female genital mutilation in Nigeria

Abstract: Nigeria, due to its large population, has the highest absolute number of female genital mutilation (FGM) worldwide, accounting for about one-quarter of the estimated 115–130 million circumcised women in the world. The objective of this review is to ascertain the current status of FGM in Nigeria. Pertinent literature on FGM retrieved from internet services [Google search on FGM in Nigeria, www.online Nigeria, PubMed of the national library of medicine www.medconsumer. Info/tropics/fgm.htm, Biomedcentral and African Journal Online (AJOL) (FGM)] and textbooks, journals, and selected references for proper understanding of the topic was included in this review. The national prevalence rate of FGM is 41% among adult women. Evidence abound that the prevalence of FGM is declining. The ongoing drive to eradicate FGM is tackled by World Health Organization, United Nations International Children Emergency Fund, Federation of International Obstetrics and Gynecology (FIGO), African Union, The economic commission for Africa, and many women organizations. However, there is no federal law banning FGM in Nigeria. There is need to eradicate FGM in Nigeria. Education of the general public at all levels with emphasis on the dangers and undesirability of FGM is paramount.

Examining inequities in incidence of catastrophic health expenditures on different healthcare services and health facilities in Nigeria.

Abstract: Objective There is limited evidence about levels of socio-economic and other differences in catastrophic health spending in Nigeria and in many sub-Saharan African countries. The study estimated the level of catastrophic healthcare expenditures for different healthcare services and facilities and their distribution across socioeconomic status (SES) groups. Methods The study took place in four Local Government Areas in southeast Nigeria. Data were collected using interviewer-administered questionnaires administered to 4873 households. Catastrophic health expenditures (CHE) were measured using a threshold of 40% of monthly non-food expenditure. We examined both total monthly health expenditure and disaggregated expenditure by source and type of care. Results The average total household health expenditure per month was 2354 Naira ($19.6). For outpatient services, average monthly expenditure was 1809 Naira ($15.1), whilst for inpatient services it was 610 Naira ($5.1). Higher health expenditures were incurred by urban residents and the better-off SES groups. Overall, 27% of households incurred CHE, higher for poorer socioeconomic groups and for rural residents. Only 1.0% of households had a member that was enrolled in a health insurance scheme. Conclusion The worse-off households (the poorest SES and rural dwellers) experienced the highest burden of health expenditure. There was almost a complete lack of financial risk protection. Health reform mechanisms are needed to ensure universal coverage with financial risk protection mechanisms.

Tube Thoracostomy: Complications and Its Management

Abstract: Background. Tube thoracostomy is widely used throughout the medical, surgical, and critical care specialities. It is generally used to drain pleural collections either as elective or emergency. Complications resulting from tube thoracostomy can occasionally be life threatening. Aim. To present an update on the complications and management of complications of tube thoracostomy. Methods. A review of the publications obtained from Medline search, medical libraries, and Google on tube thoracostomy and its complications was done. Results. Tube thoracostomy is a common surgical procedure which can be performed by either the blunt dissection technique or the trocar technique. Complication rates are increased by the trocar technique. These complications have been broadly classified as either technical or infective. Technical causes include tube malposition, blocked drain, chest drain dislodgement, reexpansion pulmonary edema, subcutaneous emphysema, nerve injuries, cardiac and vascular injuries, oesophageal injuries, residual/postextubation pneumothorax, fistulae, tumor recurrence at insertion site, herniation through the site of thoracostomy, chylothorax, and cardiac dysrhythmias. Infective complications include empyema and surgical site infection. Conclusion. Tube thoracostomy, though commonly performed is not without risk. Blunt dissection technique has lower risk of complications and is hence recommended.

Soil Degradation-Induced Decline in Productivity of Sub-Saharan African Soils: The Prospects of Looking Downwards the Lowlands with the Sawah Ecotechnology

Abstract: The paper provides an insight into the problem of land degradation in Sub-Saharan Africa, with emphasis on soil erosion and its effect on soil quality and productivity, and proposes a lowland-based rice-production technology for coping with the situation. Crop yields are, in addition to the degree of past and current erosion, determined by a number of interacting variables. This, coupled with the generally weak database on erosion-induced losses in crop yield in spite of the region’s high vulnerability to erosion, makes it difficult to attain a reliable inference on the cause-effect relationship between soil loss and productivity. Available data suggest, however, that the region is at risk of not meeting up with the challenges of agriculture in this 21st century. Based on the few studies reviewed, methodology appears to have an overwhelming influence on the erosion-productivity response, whereas issues bordering on physical environment and soil affect the shape of the response curve. We argue that the sawah ecotechnology has the potential of countering the negative agronomic and environmental impacts of land degradation in Sub-Saharan Africa. This is a farmer-oriented, low-cost system of managing soil, water, and nutrient resources for enhancing lowland rice productivity and realizing Green Revolution in the region.

Mid-infrared quantum cascade lasers

Abstract: Quantum cascade lasers (QCL) based on intersubband transitions operating at room temperature in the mid-infrared or `molecular ngerprint' spectral region (3.4{17 m) have been found useful for several applications including environmental sensing, pollution monitoring, and medical applications. In this tutorial review we present an introductory overview of the design and development of mid-infrared quantum cascade lasers and their applications. Keywords: laser, intersubband transitions, quantum cascade, mid-infrared, quantum well

Equatorial plasma bubbles and L-band scintillations in Africa during solar minimum

Abstract: . We report on the longitudinal, local time and seasonal occurrence of equatorial plasma bubbles (EPBs) and L band (GPS) scintillations over equatorial Africa. The measurements were made in 2010, as a first step toward establishing the climatology of ionospheric irregularities over Africa. The scintillation intensity is obtained by measuring the standard deviation of normalized GPS signal power. The EPBs are detected using an automated technique, where spectral analysis is used to extract and identify EPB events from the GPS TEC measurements. Overall, the observed seasonal climatology of the EPBs as well as GPS scintillations in equatorial Africa is adequately explained by geometric arguments, i.e., by the alignment of the solar terminator and local geomagnetic field, or STBA hypothesis (Tsunoda, 1985, 2010a). While plasma bubbles and scintillations are primarily observed during equinoctial periods, there are longitudinal differences in their seasonal occurrence statistics. The Atlantic sector has the most intense, longest lasting, and highest scintillation occurrence rate in-season. There is also a pronounced increase in the EPB occurrence rate during the June solstice moving west to east. In Africa, the seasonal occurrence shifts towards boreal summer solstice, with fewer occurrences and shorter durations in equinox seasons. Our results also suggest that the occurrence of plasma bubbles and GPS scintillations over Africa are well correlated, with scintillation intensity depending on depletion depth. A question remains about the possible physical mechanisms responsible for the difference in the occurrence phenomenology of EPBs and GPS scintillations between different regions in equatorial Africa.

Comparative Study of the Physicochemical Characterization of Some Oils as Potential Feedstock for Biodiesel Production

Abstract: Physicochemical properties of Cucurbita pepo, Brachystegia eurycoma, Cucumis melo, Luffa cylindrica, and Arachis hypogaea oils were studied to determine their potential as viable feedstock for biodiesel production. The nonedible oils were extracted by solvent extraction using n-hexane while the oil of Arachis hypogaea was procured. All the oils were characterized for specific gravity, pH, ash content, iodine value, acid value, saponification value, peroxide value, free fatty acid, flash point, kinematic viscosity, and refractive indices using standard methods. Cucurbita pepo seeds had very high oil content when compared to the others. Specific gravity and flash point of the oils were satisfactory. However, moisture content of some of the oils exceeded the stipulated ASTM standard for biodiesel production. Again, acid values of the nonedible oils were very high and exceeded the ASTM standard. They also exceeded the acid value of Arachis hypogaea oil except for Luffa cylindrica oil. Results indicate that the oils are potential biodiesel feedstocks. However, overall results indicate that the nonedible oils are not suitable for single-stage transesterification process to biodiesel but would be better suited for the two stage esterification and subsequent transesterification in order to obtain reasonable yields of the methyl esters.

Molecular Marker Analysis and Validation of Resistance to Cassava Mosaic Disease in Elite Cassava Genotypes in Nigeria

Abstract: Cassava (Manihot esculenta Crantz), a highly heterozygous crop, is devastated by cassava mosaic disease (CMD). The discovery of the CMD2 dominant gene is helpful in the genetic analysis of CMD resistance. Molecular markers for CMD2 gene were used to introgress CMD resistance into Latin American cassava genotypes and validated in the fi eld for 4 yr for stability of resistance conferred by CMD2. Field screening identifi ed 64 Latin American genotypes with stable resistance to CMD. Resistance to CMD of two Nigerian cassava cultivars (TMS 97/2205 and TMS 98/0505) was analyzed with markers and in the fi eld. Molecular data indicated that CMD resistance in the two Nigerian cultivars was mediated by the CMD2 gene. Results showed TMS 97/2205 to be highly resistant to CMD in three ecological zones in Nigeria. Further genetic analysis of this genotype as a source of high level of resistance to CMD using a segregating F 1 population derived from a TMS 97/2205 × NR 8083 cross was initiated using 530 simple sequence repeat (SSR) markers to identify quantitative trait loci (QTL) for CMD resistance. A marker (NS198) associated with a QTL for CMD resistance, explaining 11% of the phenotypic variance observed, was identifi ed. The combined effect of this QTL and CMD2 may account for the high level of resistance of TMS 97/2205. The resistance profi le of the evaluated CMD2 genotypes in growth cycle was not uniform and was affected by genetic background. The discovery of a new QTL (CMD3) for CMD resistance in TMS 97/2205 offers new opportunities for pyramiding CMD genes for enhanced durability of CMD resistance in cassava.

Under-five Protein Energy Malnutrition Admitted at the University of In Nigeria Teaching Hospital, Enugu: a 10 year retrospective review

Abstract: Objective: To determine the prevalence, risk factors, co-morbidities and case fatality rates of Protein Energy Malnutrition (PEM) admissions at the paediatric ward of the University of Nigeria Teaching Hospital Enugu, South-east Nigeria over a 10 year period. Design: A retrospective study using case Notes, admission and mortality registers retrieved from the Hospital’s Medical Records Department. Subjects: All children aged 0 to 59 months admitted into the hospital on account of PEM between 1996 and 2005. Results: A total of 212 children with PEM were admitted during the period under review comprising of 127 (59.9%) males and 85(40.1%) females. The most common age groups with PEM were 6 to 12 months (55.7%) and 13 to 24 months (36.8%). Marasmus (34.9%) was the most common form of PEM noted in this review. Diarrhea and malaria were the most common associated co-morbidities. Majority (64.9%) of the patients were from the lower socio-economic class. The overall case fatality rate was 40.1% which was slightly higher among males (50.9%). Mortality in those with marasmic-kwashiokor and in the unclassified group was 53.3% and 54.5% respectively. Conclusion: Most of the admissions and case fatality were noted in those aged 6 to 24 months which coincides with the weaning period. Marasmic-kwashiokor is associated with higher case fatality rate than other forms of PEM. We suggest strengthening of the infant feeding practices by promoting exclusive breastfeeding for the first six months of life, followed by appropriate weaning with continued breast feeding. Under-five children should be screened for PEM at the community level for early diagnosis and prompt management as a way of reducing the high mortality associated with admitted severe cases.

Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo

Abstract: Objective: To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin.Methods: SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release studies were conducted in rats.Results: Maximum EE% of 90.0, 91.6 and 83.0% were obtained for SLMs formed with SRMS 1:1, 1:2 and 2:1, respectively. Stable, spherical and smooth SLMs of size range 9.80 ± 1.46 µm to 33.30 ± 6.42 µm were produced. The release of gentamicin in phosphate buffer varied widely with the lipid contents. Moreover, significant (p < 0.05) amount of gentamicin was released in vivo from the SLMs.Conclusion: SRMS-based SLMs would likely offer a reliable means of delivering gentamicin intramuscularly.

Transport media for avulsed teeth: A review

Abstract: Management protocols for avulsed teeth should include management of the pulp and periodontal ligament (PDL) cells in order to improve the long-term prognosis and survival of these teeth. The use of an inappropriate transport or storage medium potentially increases the risk of PDL cell necrosis, which can result in ankylosis and replacement resorption of the tooth root. Considering the critical role of these media, an informed choice of a suitable medium is essential for a favourable outcome. The literature regarding transport media for avulsed teeth was reviewed using PubMed/MEDLINE up to February 2010. This review outlines the common storage media that are available and highlights their specific features or problems. Although HBSS, ViaSpan and Eagle's medium have great potential to maintain the PDL cells in a viable state after avulsion, the practicalities of using these solutions, the costs and the lack of ready availability to the general public make them less than ideal. Milk remains the most convenient, cheapest and readily available solution in most situations while also being capable of keeping PDL cells alive. Hence, milk remains the storage medium of choice for avulsed teeth that cannot be replanted immediately or very soon after the avulsion.

Obstetric outcome of teenage pregnancies at a tertiary hospital in Enugu, Nigeria

Abstract: Context: Maternal age, parity, and socioeconomic class are important determinants of obstetric outcome of pregnancy. Teenage pregnancy constitutes a high risk pregnancy with complications arising from a combination of physiological, anatomical, and socioeconomic factors Objective: The objective was to determine the current incidence of all teenage pregnancies and their obstetric outcomes at UNTH, Enugu. Materials and Methods: This was a retrospective review of all teenage pregnancies at University of Nigeria Teaching Hospital, Enugu over a 6-year period (2000--2005). A total of 74 teenage pregnancies were analyzed and compared with 105 controls (adult mothers). Results: Records of 74 teenage pregnancies were identified within the study period which constitutes 1.67% of 4422 deliveries within the period. Majority of the teenagers (78.3%) were nulliparous. There was statistically significant differences between the teenage mothers and older mothers in the rate of unemployment (75.7% vs. 24.8%, P = 0.000), booking status (41.9% vs. 100%, P = 0.000) anemia (32.4% vs. 24.8%, P = 0.001), unsure of last menstrual period (32.4% vs. 15.2%, P = 0.007), caesarean section (18.9% vs. 10.5%, P = 0.000), cephalopelvic disproportion as an indication for caesarean section (9.4% vs. 3.8%, P = 0.001), preterm delivery (18.9% vs. 11.4%, P = 0.001), low birth weight (23.0% vs. 10.5%, P = 0.005), episiotomy (61.7% vs. 28.7%, P = 0.001), instrumental delivery (6.8% vs. 2.9% P = 0.001), Apgar score at 1 minute (35.1% vs. 19.1% P = 0.005), and perinatal mortality (16.2% vs. 12.4%). There were no maternal deaths. Conclusion: Pregnant teenagers are at higher risk than their older counterparts. Female socioeducational development and proper use of contraceptive services will help reduce teenage pregnancy rate, while perinatal care will help to minimize it associated hazards

Congenital malformations among newborns admitted in the neonatal unit of a tertiary hospital in Enugu, South-East Nigeria - a retrospective study

Abstract: Congenital abnormalities are not uncommon among newborns and contribute to neonatal and infant morbidity and mortality. The prevalence and pattern of presentation vary from place to place. Many a time the exact etiology is unknown but genetic and environmental factors tend to be implicated. The objective of this study was to determine the prevalence of congenital malformations among newborns admitted in a tertiary hospital in Enugu, the nature of these abnormalities and the outcome/prognosis. For purposes of this study, congenital abnormalities are defined as obvious abnormality of structure or form which is present at birth or noticed within a few days after birth. A cross-sectional retrospective study in which a review of the records of all babies admitted in the Newborn Special Care Unit (NBSCU) of the University of Nigeria Teaching Hospital (UNTH), Ituku/Ozalla, Enugu over a four year period (January 2007-April 2011) was undertaken. All babies admitted in the unit with the diagnosis of congenital abnormality were included in the study. Information extracted from the records included characteristics of the baby, maternal characteristics, nature/type of abnormalities and outcome. Data obtained was analyzed using SPSS 13. Rates and proportions were calculated with 95% confidence interval. The proportions were compared using students T-test. Level of significance was set at P < 0.05 Seventeen (17) out of a total of six hundred and seven newborn babies admitted in the newborn unit of UNTH over the study period (Jan 2007-March 2011) were found to have congenital abnormalities of various types, giving a prevalence of 2.8%. Common abnormalities seen in these babies were mainly surgical birth defects and included cleft lip/cleft palate, neural tube defects (occurring either singly or in combination with other abnormalities), limb abnormalities (often in combination with neural tube defects of various types), omphalocoele, umbilical herniae, ano-rectal malformations and dysmorphism associated with multiple congenital abnormalities. The results of this study show that 2.8% of babies admitted to a Newborn Special Care Unit in a teaching hospital in Enugu had congenital abnormalities and that the commonest forms seen were mainly surgical birth defects and includes cleft lip/cleft palate and neural tube defects.

Current Trends in the Management of Gastroesophageal Reflux Disease: A Review

Abstract: Gastroesophageal reflux disease (GERD) is a chronic disorder of the upper gastrointestinal tract with global distribution. The incidence is on the increase in different parts of the world. In the last 30 to 40 years, research findings have given rise to a more robust understanding of its pathophysiology, clinical presentation, and management. The current definition of GERD (The Montreal definition, 2006) is not only symptom-based and patient-driven, but also encompasses esophageal and extraesophageal manifestations of the disease. The implication is that the disease can be confidently diagnosed based on symptoms alone. Nonerosive reflux disease (NERD) remains the predominant form of GERD. Current thinking is that NERD and erosive reflux disease (ERD) are distinct phenotypes of GERD rather than the old concept which regarded them as components of a disease spectrum. Non erosive reflux disease is a very heterogeneous group with significant overlap with other functional gastrointestinal disorders. There is no gold standard for the diagnosis of GERD. Esophageal pH monitoring and intraluminal impedance monitoring have thrown some light on the heterogeneity of NERD. A substantial proportion of GERD patients continue to have symptoms despite optimal PPI therapy, and this has necessitated research into the development of new drugs. Several safety concerns have been raised about chronic use of proton pump inhibitors but these are yet to be substantiated in controlled studies. The debate about efficacy of long-term medical treatment compared to surgery continues, however, recent data indicate that modern surgical techniques and long-term PPI therapy have comparable efficacy. These and other issues are subjects of further research.

Biotechnological Tools for Environmental Sustainability: Prospects and Challenges for Environments in Nigeria—A Standard Review

Abstract: The environment is a very important component necessary for the existence of both man and other biotic organisms. The degree of sustainability of the physical environment is an index of the survival and well-being of the entire components in it. Additionally, it is not sufficient to try disposing toxic/deleterious substances with any known method. The best method of sustaining the environment is such that returns back all the components (wastes) in a recyclable way so that the waste becomes useful and helps the biotic and abiotic relationship to maintain an aesthetic and healthy equilibrium that characterizes an ideal environment. In this study, the method investigated includes biological method of environmental sustainability which seeks to investigate the various biotechnological tools (biotools) in current use and those undergoing investigations for future use.

Social participation in city governance and urban livelihoods: Constraints to the informal recycling economy in Aba, Nigeria

Abstract: The informal sector in cities of the developing world is often analyzed from the prism of urban poverty, social exclusion and limited social integration, and lack of power. While such issues have commanded considerable attention in development literature, contribution of the sector to urban governance and barriers to its social participation in the urban governance process appears to have received relatively little epistemological treatment. The aim of this paper is, therefore, to critically examine the status of solid waste management (SWM) in urban governance and constraints to participation of the informal waste sector in governance of the city of Aba, Nigeria. The paper which is framed around the Global Campaign on Urban Governance is based on a survey and focus group discussions (FGDs) with informal waste workers, and key-informant interviews (KIIs) with environment and development policy experts. Findings indicate that the sector while making clear development contributions is not recognized in SWM policy and practice. It was also found that the sector lacks education, self-organization and knowledge of civil rights for an effective social participation process. The study while arguing that effective social participation requires a supportive environment and political will acknowledges the enormity of the barriers to the informal waste sector but suggests that social innovation initiatives can potentially counter trends of social exclusion and foster greater social inclusion of the informal waste workers. Interventions to strengthen solid waste governance and development by the informal waste sector in Aba, Nigeria are also suggested.

TEMPORAL AND SPECTRAL EVOLUTION IN X- AND γ-RAYS OF MAGNETAR 1E 1547.0–5408 SINCE ITS 2008 OCTOBER OUTBURST: THE DISCOVERY OF A TRANSIENT HARD PULSED COMPONENT AFTER ITS 2009 JANUARY OUTBURST

Abstract: The magnetar 1E 1547.0-5408 exhibited outbursts in 2008 October and 2009 January. In this paper, we present in great detail the evolution of the temporal and spectral characteristics of the persistent total and pulsed emission of 1E 1547.0-5408 between ~1 and 300 keV starting on 2008 October 3 and ending in 2011 January. We analyzed data collected with the Rossi X-ray Timing Explorer (RXTE) the International Gamma-Ray Astrophysics Laboratory (INTEGRAL), and the Swift satellite. We report the evolution of the pulse frequency, and the measurement at the time of the onset of the 2009 January outburst of an insignificant jump in frequency, but a major frequency derivative jump $\Delta {\dot{ u }}$ of +(1.30 ± 0.14) × 10-11 Hz s-1 ($\Delta \dot{ u }/\dot{ u }$ of -0.69 ± 0.07). Before this $\dot{ u }$ glitch, a single broad pulse is detected, mainly for energies below ~10 keV. Surprisingly, ~11 days after the glitch a new transient high-energy (up to ~150 keV) pulse appears with a Gaussian shape and width 0.23, shifted in phase by ~0.31 compared to the low-energy pulse, which smoothly fades to undetectable levels in ~350 days. We report the evolution of the pulsed-emission spectra. For energies 2.5-10 keV all pulsed spectra are very soft with photon indices Γ between -4.6 and -3.9. For ~10-150 keV, after the $\dot{ u }$ glitch, we report hard non-thermal pulsed spectra, similar to what has been reported for the persistent pulsed emission of some anomalous X-ray pulsars. This pulsed hard X-ray emission reached maximal luminosity 70 ± 30 days after the glitch epoch, followed by a gradual decrease by more than a factor of 10 over ~300 days. These characteristics differ from those of the total emission. Both, the total soft X-ray (1-10 keV) and hard X-ray (10-150 keV) fluxes, were maximal already 2 days after the 2009 January outburst, and decayed by a factor of gsim3 over ~400 days. The total spectra can be described with a blackbody (kT values varying in the range 0.57-0.74 keV) plus a single power-law model. The photon index exhibited a hardening (~ - 1.4 to ~ - 0.9) with time, correlated with a decrease in flux in the 20-300 keV band. We discuss these findings in the framework of the magnetar model.

A systematic review of the safety and efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy.

Abstract: Malaria during pregnancy, particularly Plasmodium falciparum malaria, has been linked to increased morbidity and mortality, which must be reduced by both preventive measures and effective case management. The World Health Organization (WHO) recommends artemisinin-based combination therapy (ACT) to treat uncomplicated falciparum malaria during the second and third trimesters of pregnancy, and quinine plus clindamycin during the first trimester. However, the national policies of many African countries currently recommend quinine throughout pregnancy. Therefore, the aim of this article is to provide a summary of the available data on the safety and efficacy of artemether-lumefantrine (AL) in pregnancy. An English-language search identified 16 publications from 1989 to October 2011 with reports of artemether or AL exposure in pregnancy, including randomized clinical trials, observational studies and systematic reviews. Overall, there were 1,103 reports of AL use in pregnant women: 890 second/third trimester exposures; 212 first trimester exposures; and one case where the trimester of exposure was not reported. In the second and third trimesters, AL was not associated with increased adverse pregnancy outcomes as compared with quinine or sulphadoxine-pyrimethamine, showed improved tolerability relative to quinine, and its efficacy was non-inferior to quinine. There is evidence to suggest that the pharmacokinetics of anti-malarial drugs may change in pregnancy, although the impact on efficacy and safety needs to be studied further, especially since the majority of studies report high cure rates and adequate tolerability. As there are fewer reports of AL safety in the first trimester, additional data are required to assess the potential to use AL in the first trimester. Though the available safety and efficacy data support the use of AL in the second and third trimesters, there is still a need for further information. These findings reinforce the WHO recommendation to treat uncomplicated falciparum malaria with quinine plus clindamycin in early pregnancy and ACT in later pregnancy.

Ischemic stroke and neuroprotection

Abstract: Stroke is a major cause of morbidity and mortality in both developed and developing countries of the world. Greater understanding of the pathophysiology of neuronal damage in ischemic stroke has generated interest in neuroprotection as a management strategy. This paper aims to review the current concept and place of neuroprotection in ischemic stroke. An extensive search of all materials related to the topic was made using library sources including Pubmed and Medline searches. Current research findings were also included. The findings are as presented. Neuroprotection is an increasingly recognized management strategy in ischemic stroke that promises to assist clinicians in reducing stroke mortality rates and improving the quality of life of survivors.

Temporal and spectral evolution in X- and gamma-rays of magnetar 1E 1547.0-5408 since its October 2008 outburst: the discovery of a transient hard pulsed component after its January 2009 outburst

Abstract: The magnetar 1E 1547.0-5408 exhibited outbursts in October 2008 and January 2009. In this paper we present in great detail the evolution of the temporal and spectral characteristics of the persistent total and pulsed emission of 1E 1547.0-5408 between ~1 and 300 keV starting in October 3, 2008, and ending in January 2011. We analyzed data collected with the Rossi X-ray Timing Explorer, the International Gamma-Ray Astrophysics Laboratory and the Swift satellite.