Showing papers by "University of Nigeria, Nsukka published in 2018"

Liposomal Drug Delivery Systems and Anticancer Drugs

Abstract: Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site. Most of the active pharmaceutical ingredients (APIs) used in chemotherapy are highly cytotoxic to both cancer and normal cells. Accordingly, targeting the tumour vasculatures is essential for tumour treatment. In this context, encapsulation of anti-cancer drugs within the liposomal system offers secure platforms for the targeted delivery of anti-cancer drugs for the treatment of cancer. This, in turn, can be helpful for reducing the cytotoxic side effects of anti-cancer drugs on normal cells. This short-review focuses on the use of liposomes in anti-cancer drug delivery.

Young rural women’s participation in the e-wallet programme and usage intensity of modern agricultural inputs in Nigeria

Abstract: We assess the extent young rural women (YRW) participate in the federal government (FGN) e-wallet programme and the subsequent impact on usage intensity of modern agricultural inputs in Nigeria. Si...

Roadmap to Achieve 25% Hypertension Control in Africa by 2025

Abstract: Background The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority action to reduce heart disease and stroke on the continent. Objectives The aim of this PASCAR roadmap on hypertension was to develop practical guidance on how to implement strategies that translate existing knowledge into effective action and improve detection, treatment and control of hypertension and cardiovascular health in sub-Saharan Africa (SSA) by the year 2025. Methods Development of this roadmap started with the creation of a consortium of experts with leadership skills in hypertension. In 2014, experts in different fields, including physicians and nonphysicians, were invited to join. Via face-to-face meetings and teleconferences, the consortium made a situation analysis, set a goal, identified roadblocks and solutions to the management of hypertension and customized the World Heart Federation roadmap to Africa. Results Hypertension is a major crisis on the continent but very few randomized controlled trials have been conducted on its management. Also, only 25.8% of the countries have developed or adopted guidelines for management of hypertension. Other major roadblocks are either government and health-system related or health care professional or patient related. The PASCAR hypertension task force identified a 10-point action plan to be implemented by African ministries of health to achieve 25% control of hypertension in Africa by 2025. Conclusions Hypertension affects millions of people in SSA and if left untreated, is a major cause of heart disease and stroke. Very few SSA countries have a clear hypertension policy. This PASCAR roadmap identifies practical and effective solutions that would improve detection, treatment and control of hypertension on the continent and could be implemented as is or adapted to specific national settings.

Adoption of improved crop varieties by involving farmers in the e-wallet program in Nigeria

Abstract: The amount of improved seed used in Nigeria is extremely low. Overall, only 5–10% of cultivated land is planted with improved seeds, and about 10% of rural farmers use improved varieties. The objec...

Planning and implementing sustainability in higher education institutions: an overview of the difficulties and potentials

Abstract: Planning in sustainable development is believed to be an important element in allowing higher education institutions to set their goals and to commit themselves towards undertaking concrete actions and measures at all levels in order to implement sustainability. Yet, there is a paucity of research that has looked at the extent to which planning can support institutions of higher education to assess their performances and to determine whether the set aims have been met. This research gap needs to be met to allow a better understanding of how planning can help to promote the integration of the three components of sustainable development – economic development, social development and environmental protection in higher education. This paper explores the challenges for planning the sustainable development in higher education, also outlining the potentials lessons learned that could assist in improving Education for Sustainable Development efforts in Higher Education Institutions. Among its main results...

Assessment of the quality of groundwaters proximal to dumpsites in Awka and Nnewi metropolises: a comparative approach

Abstract: Using integrated geoscientific approach, this paper assessed the quality of groundwaters around open dumpsites in Awka and Nnewi metropolises, Nigeria. Ten water samples for each of the metropolises were subjected to hydrogeochemical analysis. Seventeen parameters were subjected to correlation, factor, cluster, pollution index, and quality analyses. The interrelationships between parameters were obtained. The order of cation and anion dominance in Awka is Ca > Mg > Na > K and Cl > HCO3 > SO4 > NO3 > PO4, respectively. In Nnewi, the order is Na > Ca > K>Mg and Cl > SO4 > HCO3 > PO4 > NO3, respectively. Heavy metals occurred in the order Pb > Fe > Cu > Cd in Awka and Fe > Cu > Pb > Cd in Nnewi. Five water types and three water facies dominate Awka metropolis, whereas eight water types and four water facies dominate Nnewi metropolis. The physicochemical parameters for both metropolises are well within quality standards. However, pH of most of the samples is off standard limits, classing the waters as neutral to slightly acidic. Also, the groundwaters are generally contaminated with heavy metals. Pollution index of Awka metropolis (ranging 0.542–73.083) is higher than that of Nnewi metropolis (ranging 0.069–6.617). Further, Pb has the highest contamination factor in Awka metropolis, whereas Cd has the highest in Nnewi metropolis. Based on the gross characteristics observed in both metropolises, the waters are considered unfit for drinking purposes, but could be used for other domestic and industrial purposes which do not require them being used for food processing.

Calcined Corncob-Kaolinite Combo as New Sorbent for Sequestration of Toxic Metal Ions From Polluted Aqua Media and Desorption

Abstract: This study investigated a new area of improving the adsorption capacity of clay using corn cob as an alternative means of clay modification to the more expensive and complicated chemical treatment techniques. Kaolinite Clay (KC), Calcined corncob-kaolinite Combo (CCKC), and Corncob (CC) adsorbents were utilized. The adsorbents were characterized by Fourier Transform-Infrared (FT-IR) Spectroscopy, Scanning Electron Microscopy (SEM), X-ray fluorescence spectroscopy, and Brunauer-Emmett-Teller (BET) surface area analyzer. Batch adsorption methodology was used to investigate the effect of pH, initial metal concentration, adsorbent dose, and contact time on adsorption of Pb (II) and Cd (II). A slight increase in BET surface area of 29.31 m2/g for CCKC from 14.12 m2/g for raw KC was achieved. The trend of metal adsorption on the adsorbents was in the order CC>CCKC>KC. The Langmuir isotherm was found to present the best fit for the unmodified adsorbents while the Freundlich was applicable for CCKC indicating multilayer heterogeneous surface. The pseudo second order kinetic model was found to be suitable in the kinetic analysis. Thermodynamic studies revealed a spontaneous physical adsorption process of metal ions on CCKC. The combo adsorbent showed highest percentage desorption (>70%) of Cd and Pb ions in both acid and basic media compared to the other adsorbents. The results of the study established the efficiency of calcined corn cob kaolinite combo as suitable adsorbent for metal ions.

Cross-cultural invariances in the architecture of shame.

Abstract: Human foragers are obligately group-living, and their high dependence on mutual aid is believed to have characterized our species' social evolution. It was therefore a central adaptive problem for our ancestors to avoid damaging the willingness of other group members to render them assistance. Cognitively, this requires a predictive map of the degree to which others would devalue the individual based on each of various possible acts. With such a map, an individual can avoid socially costly behaviors by anticipating how much audience devaluation a potential action (e.g., stealing) would cause and weigh this against the action's direct payoff (e.g., acquiring). The shame system manifests all of the functional properties required to solve this adaptive problem, with the aversive intensity of shame encoding the social cost. Previous data from three Western(ized) societies indicated that the shame evoked when the individual anticipates committing various acts closely tracks the magnitude of devaluation expressed by audiences in response to those acts. Here we report data supporting the broader claim that shame is a basic part of human biology. We conducted an experiment among 899 participants in 15 small-scale communities scattered around the world. Despite widely varying languages, cultures, and subsistence modes, shame in each community closely tracked the devaluation of local audiences (mean r = +0.84). The fact that the same pattern is encountered in such mutually remote communities suggests that shame's match to audience devaluation is a design feature crafted by selection and not a product of cultural contact or convergent cultural evolution.

Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies.

Abstract: Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities. Molecular docking showed an excellent binding interaction of the synthesised compounds with the receptors, with 17c showing the highest binding energy (-12.50 kcal/mol). Compounds 17c and 17i inhibited carrageenan-induced rat paw oedema at 72, 76, and 80% and 64, 73, and 78% at 1 h, 2 h, and 3 h, respectively. In the analgesic activity experiment, compounds 17c, 17 g, and 17i had ED50 (µM/kg) of 96, 127, and 84 after 0.5 h; 102, 134, and 72 after 1 h and 89, 156, and 69 µM/kg after 2 h, respectively, which were comparable with 156, 72, and 70 µM/kg for celecoxib. The ulcerogenic index of the most active derivatives 17c and 17i were 0.82 and 0.89, respectively, comparable to 0.92 for celecoxib. The physicochemical studies of the new derivatives showed that they will not have oral bioavailability problems.

Gendered health systems: evidence from low- and middle-income countries.

Abstract: Gender is often neglected in health systems, yet health systems are not gender neutral. Within health systems research, gender analysis seeks to understand how gender power relations create inequities in access to resources, the distribution of labour and roles, social norms and values, and decision-making. This paper synthesises findings from nine studies focusing on four health systems domains, namely human resources, service delivery, governance and financing. It provides examples of how a gendered and/or intersectional gender approach can be applied by researchers in a range of low- and middle-income settings (Cambodia, Zimbabwe, Uganda, India, China, Nigeria and Tanzania) to issues across the health system and demonstrates that these types of analysis can uncover new and novel ways of viewing seemingly intractable problems. The research used a combination of mixed, quantitative, qualitative and participatory methods, demonstrating the applicability of diverse research methods for gender and intersectional analysis. Within each study, the researchers adapted and applied a variety of gender and intersectional tools to assist with data collection and analysis, including different gender frameworks. Some researchers used participatory tools, such as photovoice and life histories, to prompt deeper and more personal reflections on gender norms from respondents, whereas others used conventional qualitative methods (in-depth interviews, focus group discussion). Findings from across the studies were reviewed and key themes were extracted and summarised. Five core themes that cut across the different projects were identified and are reported in this paper as follows: the intersection of gender with other social stratifiers; the importance of male involvement; the influence of gendered social norms on health system structures and processes; reliance on (often female) unpaid carers within the health system; and the role of gender within policy and practice. These themes indicate the relevance of and need for gender analysis within health systems research. The implications of the diverse examples of gender and health systems research highlighted indicate that policy-makers, health practitioners and others interested in enhancing health system research and delivery have solid grounds to advance their enquiry and that one-size-fits-all heath interventions that ignore gender and intersectionality dimensions require caution. It is essential that we build upon these insights in our efforts and commitment to move towards greater equity both locally and globally.

Overview of soil-machine interaction studies in soil bins

Abstract: This paper presents a review of soil-machine interaction studies in soil bin test facilities; it provides an insight on the historical background, concepts, past and present studies and future research direction. Soil-machine interaction studies seek to provide scientific knowledge on how tillage tools and traction devices interact with the terrain over which they work or move. Variables usually investigated include; force required to pull or push the tillage tool, vertical and lateral forces on tools, soil failure patterns, soil particles displacement, force generated at the interface of the wheel and the soil, wheel sinkage, rolling resistance, wheel contact area estimation, and soil stress at different depths. Soil bin facility is a model laboratory for tillage and traction experiments. The main components include the soil bin that models the ground; mobile tool carrier that models tool/implement frame; soil engaging tool/device for modeling tillage tools or traction elements; power source and the drive system that model the prime mover; soil conditioning equipment for preparation of the soil before experiments; motion control system for controlling the moving components along the rails of the soil bin; measurement/data acquisition and analysis system for real time measurement, analysis and display of variables during experiments; a lifting system for hoisting of heavy components. Simulations with Finite Element and Discrete Element Methods together with experimental analyses in the field or the soil bin are applied by many researchers in studying soil-machine interaction. Results of this kind of study are useful for design, modeling, prediction, performance evaluation and optimization of different kinds of off-road vehicles, earth moving machines, tractors, tillage tools/implements, traction elements, wheeled mobile robots and autonomous traction vehicles.

Towards a Sustainable Electricity Supply in Nigeria: The Role of Decentralized Renewable Energy System

Abstract: In Nigeria, access to reliable and stable supply of electricity is a major challenge for both the urban and rural dwellers. In this study, comprehensive review of accessibility to clean and modern energy in Nigeria has been carried out. Also, this paper examines the potential of renewable energy (RE) resources in Nigeria that can be harnessed for continuous energy supply and the government’s efforts to ensure RE‘s sustainability. Nigeria is endowed with abundant energy resources but the existing electric energy infrastructures are unable to meet the energy demands of teeming population. There is imbalance in energy supply and demand in the country. Over the period from 2000 to 2014, there was an average of about 2.35 billion kWh of energy gap between energy production and energy consumption. The highest electricity consumption per capita recorded so far was 156 kWh in 2012. This makes Nigeria one of the country with the lowest electricity consumption on per capita basis in the world. In order to improve access to clean energy supply and achieve sustainable development, this paper pin points the significance of decentralized renewable energy systems and needs for the government to review the policies on renewable energy development in the country.

Determinants of livelihood diversification strategies in Eastern Tigray Region of Ethiopia

Abstract: In Ethiopia, farm households engage and pursue diverse off-farm and non-farm livelihood activities to cope with diverse challenges such as drought. Due to the unstable and meagre agricultural context of the study area, farm income alone could not feed the ever increasing population. Without adopting context based livelihood diversification strategies; the challenge it presents could neither meet nor attain household food security and improve livelihood security. The objective of the study was to analyse the determinants of livelihood diversification strategies among rural households in Eastern Tigray Region of Ethiopia. Multistage sampling technique was used in selecting the study sites and 485 sample respondents. Data were triangulated with information collected using focus group discussion and key informants interview to draw qualitative conclusion. Majority (83.1%) of the farmers were able to diversify their livelihoods into either off-farm or non-farm or combined income activities, whereas the remaining 16.91% of the households were unable to diversify; often lacking the means to engage in any form of income-generating activity apart from agricultural activities. Results of the multinomial logistic regression model revealed that households choice and adoption of livelihood diversification strategies were positively affected by households level of education, access to credit, income, membership to cooperatives, land size, and farm input use, whereas age, dependency ratio, family size, access to extension services, distance to market, livestock ownership and agro-ecology negatively affected. Diversification into non-farm activities plays a significant role in the context of inadequate and rain-fed-dependent agricultural income households. Households who diversified their livelihood activities are the ones who able to build better asset and less vulnerable than the undiversified ones. Smallholder farmers’ food security and livelihood improvement can only be realized if the government give due attention and put the right policy measures in place that support non-farm livelihood diversification as part of national job creation for saving life of many people and better livelihood.

Dermatophytes and dermatophytosis in the eastern and southern parts of Africa.

Abstract: Dermatophytosis is currently a disease of global importance and a public health burden. It is caused by dermatophytes, which attack and grow on dead animal keratin. Dermatophytes belong to three genera, namely, Epidermophyton, Microsporum, and Trichophyton. The predominant clinical forms and causative agents vary from one region of the world to another. Poor socioeconomic status, high population densities, and poor sanitary conditions are some of the factors responsible for the high prevalence of dermatophytosis in many developing countries, which include countries in southern and eastern Africa, the focus of this review. To the best of our knowledge, there is currently no review article on published findings on dermatophytosis in the eastern and southern parts of Africa. This information will be of interest to the medical and research community since the world has become a global village. This review covers published research findings in eastern and southern regions of Africa until this date. The countries covered in the current review include Kenya, Ethiopia, Tanzania, South Africa, Mozambique, Madagascar, Malawi, Rwanda, Burundi, Uganda, Zambia, Zimbabwe, and Botswana. T. violaceum is the most common human etiological agent in all the countries under review with prevalence ranging from 56.7% to 95%, except for Madagascar (M. langeronii, reclassified as M. audouinii), Uganda (M. gypseum) and Malawi (M. audouinii). Tinea capitis was the most clinical type, followed by tinea corporis. Etiological agents of animal dermatophytoses were variable in the countries where they were reported. Major risk factors for dermatophytoses are age, climatic, and socioeconomic factors.

How Transformational Leadership Influences Work Engagement Among Nurses: Does Person-Job Fit Matter?

Abstract: The current study examines whether person-job fit moderates the relationship between transformational leadership and work engagement. Data were collected using cross-sectional design from 224 (15 male and 209 female) hospital nurses. Participants completed measures of transformational leadership, person-job fit, and work engagement. Moderated multiple regression results showed that transformational leadership had a significant positive predictive relationship with work engagement, and person-job fit had a significant positive predictive relationship with work engagement. Simple slope analysis showed that person-job fit moderated the relationship between transformational leadership and work engagement such that transformational leadership was more positively related to work engagement for nurses with high person-job fit compared with those with low person-job fit. Thus, all the hypotheses were confirmed. The findings were discussed, and suggestions for future research were offered.

The Extraordinary Outburst in the Massive Protostellar System NGC 6334I-MM1: Flaring of the Water Masers in a North–South Bipolar Outflow Driven by MM1B

Abstract: We compare multi-epoch sub-arcsecond VLA imaging of the 22 GHz water masers toward the massive protocluster NGC6334I observed before and after the recent outburst of MM1B in (sub)millimeter continuum. Since the outburst, the water maser emission toward MM1 has substantially weakened. Simultaneously, the strong water masers associated with the synchrotron continuum point source CM2 have flared by a mean factor of 6.5 (to 4.2 kJy) with highly-blueshifted features (up to 70 km/s from LSR) becoming more prominent. The strongest flaring water masers reside 3000 au north of MM1B and form a remarkable bow shock pattern whose vertex coincides with CM2 and tail points back to MM1B. Excited OH masers trace a secondary bow shock located ~120 au downstream. ALMA images of CS (6-5) reveal a highly-collimated north-south structure encompassing the flaring masers to the north and the non-flaring masers to the south seen in projection toward the MM3-UCHII region. Proper motions of the southern water masers over 5.3 years indicate a bulk projected motion of 117 km/s southward from MM1B with a dynamical time of 170 yr. We conclude that CM2, the water masers, and many of the excited OH masers trace the interaction of the high velocity bipolar outflow from MM1B with ambient molecular gas. The previously-excavated outflow cavity has apparently allowed the radiative energy of the current outburst to propagate freely until terminating at the northern bow shock where it strengthened the masers. Additionally, water masers have been detected toward MM7 for the first time, and a highly-collimated CS (6-5) outflow has been detected toward MM4.

A masing event in NGC 6334I: contemporaneous flaring of hydroxyl, methanol, and water masers

Abstract: As a product of the maser monitoring program with the 26m telescope of the Hartebeesthoek Radio Astronomy Observatory (HartRAO), we present an unprecedented, contemporaneous flaring event of 10 maser transitions in hydroxyl, methanol, and water that began in 2015 January in the massive star-forming region NGC6334I in the velocity range -10 to -2 km/s. The 6.7 GHz methanol and 22.2 GHz water masers began flaring within 22 days of each other, while the 12.2 GHz methanol and 1665 MHz hydroxyl masers flared 80 and 113 days later respectively. The 1665 MHz, 6.7 GHz, and 22.2 GHz masers have all remained in their flared state for nearly 3 years. The brightest flaring components increased by factors of 66, 21, 26, and 20 in the 12.2 and 6.7 GHz methanol, 1665 MHz hydroxyl and 22.2 GHz water maser transitions respectively; some weaker components increased by up to a factor of 145. We also report new maser emission in the 1720, 6031, and 6035 MHz OH lines and the 23.1 GHz methanol line, along with the detection of only the fifth 4660 MHz OH maser. We note the correlation of this event with the extraordinary (sub)millimeter continuum outburst from the massive protostellar system NGC6334I-MM1 and discuss the implications of the observed time lags between different maser velocity components on the nature of the outburst. Finally, we identify two earlier epoch maser flaring events likely associated with this object, which suggest a recurring accretive phenomenon that generates powerful radiative outbursts.

Deriving an optimal threshold of waist circumference for detecting cardiometabolic risk in sub-Saharan Africa

Abstract: Waist circumference (WC) thresholds derived from western populations continue to be used in sub-Saharan Africa (SSA) despite increasing evidence of ethnic variation in the association between adiposity and cardiometabolic disease and availability of data from African populations. We aimed to derive a SSA-specific optimal WC cut-point for identifying individuals at increased cardiometabolic risk. We used individual level cross-sectional data on 24 181 participants aged ⩾15 years from 17 studies conducted between 1990 and 2014 in eight countries in SSA. Receiver operating characteristic curves were used to derive optimal WC cut-points for detecting the presence of at least two components of metabolic syndrome (MS), excluding WC. The optimal WC cut-point was 81.2 cm (95% CI 78.5–83.8 cm) and 81.0 cm (95% CI 79.2–82.8 cm) for men and women, respectively, with comparable accuracy in men and women. Sensitivity was higher in women (64%, 95% CI 63–65) than in men (53%, 95% CI 51–55), and increased with the prevalence of obesity. Having WC above the derived cut-point was associated with a twofold probability of having at least two components of MS (age-adjusted odds ratio 2.6, 95% CI 2.4–2.9, for men and 2.2, 95% CI 2.0–2.3, for women). The optimal WC cut-point for identifying men at increased cardiometabolic risk is lower (⩾81.2 cm) than current guidelines (⩾94.0 cm) recommend, and similar to that in women in SSA. Prospective studies are needed to confirm these cut-points based on cardiometabolic outcomes.

Nutrient, phytochemical, and antinutrient composition of Citrus maxima fruit juice and peel extract.

Abstract: Nutrient, phytochemical, and antinutrient composition of Citrus maxima fruit juice and peel extract were determined. The fruit was procured from a garden in Trans-Ekulu, Enugu East Local Government Area, Enugu State, Nigeria. Mature undamaged Citrus maxima fruits were thoroughly washed with distilled water to remove contamination, dirt, and air-dried. The peel was separated from the pulp. The pulp (100 g) was blended and filtered through a muslin cloth to obtain a clear juice. The peel (50 g) was macerated with 200 ml of ethanol for 20 min. The peel extract was filtered through filter paper. The supernatant was concentrated by rotary evaporation. The peel extract was weighed and stored in a plastic container until needed. Proximate, mineral, vitamins, antinutrient, and phytochemical composition of the juice and peel extract were determined using standard procedures. Citrus maxima peel extract contains significantly (p Na > Ph > Fe > Mg > K in the juice and Ca > Ph > Na > Fe > K > Mg in the peel extract. Vitamin C content of the juice and peel extract were 26.36 mg/100 g and 19.34 mg/100 g, respectively. Citrus maxima peel is highly nutritive and rich in phytochemicals, further research is recommended to investigate its therapeutic effect.

Modified clay minerals for environmental applications

Abstract: Clays and clay minerals are one of the important groups of materials that are widely used in environmental cleanup applications. The natural clay minerals are hydrophilic in nature, and hold high chemical stability and cation exchange capacity. Owing to the native electronegative surface properties and cation exchange capacities, natural clay minerals are good adsorbents of heavy metal cations and many other cationic organic contaminants. The modification of clay minerals can significantly improve their surface properties that consequently increase their contaminant removal capacities and efficiencies. The current chapter presents a brief overview of various clay modification and surface engineering methods, and discusses how the resultant modified clay products can remediate various environmental contaminants.

Care of the elderly in Nigeria: Implications for policy

Abstract: Nigeria has no functional national policy on the care and welfare of older persons. Changing demographics in Nigeria, in addition to the breakdown of the family structure and absence of a social se...

Oil Spillage and Heavy Metals Toxicity Risk in the Niger Delta, Nigeria

Abstract: Background. Heavy metals are known to elicit toxic effects which negatively affect human health. Crude oil is known to contain heavy metals and oil spills contaminate the environment and can result...

Sexual and reproductive health services (SRHS) for adolescents in Enugu state, Nigeria: a mixed methods approach

Abstract: Availability and accessibility of sexual and reproductive health services for adolescents are very crucial for prevention and control of sexual and reproductive health problems. These services also play vital roles in the promotion of adolescents’ sexual and reproductive health generally. The main purpose of the study was to determine the availability and accessibility (geographical and financial) of sexual and reproductive health services (SRHS) among adolescents in Enugu State, Nigeria. A mixed methods approach was adopted for the study. 192 health facilities were reached to check availability of SRH services. Randomly sampled 1447 adolescents (12–22 years) completed the questionnaire correctly. Twenty-seven interviews and 18 group discussions were conducted. Instruments for data collection consisted of a checklist, a questionnaire, a focus group discussion guide and an in-depth interview guide. All instruments were pre-tested. Quantitative data were analyzed using descriptive statistics and Chi-square tests. NVivo 11 Pro software was used to code and thematically analyze the qualitative data. A total of 1447 adolescents (between 12 and 22 years) completed the questionnaire correctly. Among these adolescents, males constituted 42.9% while females were 57.1%. The majority (86.7%) of the adolescents reported availability of safe motherhood services, and 67.5% reported availability of services for prevention and management of STIs and HIV and AIDS. The majority reported that these services were geographically accessible but few were financially accessible to adolescents. However, qualitative data revealed that available services were not specifically provided for adolescents but for general use. Age (p = ≤ .05), education (p = ≤ .05) and income (p = ≤ .05) were found to be significantly associated with access to SRHS. SRHS were generally physically available but not financially accessible to adolescents. Adolescents’ clinics were not available and this could affect the access of SRHS by adolescents. Education and income were significantly associated with access to SRHS.

Corporate board characteristics and environmental disclosure quantity: Evidence from South Africa (integrated reporting) and Nigeria (traditional reporting)

Abstract: The study examined the influence of corporate board characteristics on environmental disclosure quantity of listed firms in two leading emerging economies: South Africa and Nigeria which practice i...

Tools for Detection of Schistosomiasis in Resource Limited Settings.

Abstract: Schistosomiasis is a debilitating disease affecting over 200 million people, with the highest burden of morbidity and mortality in African countries. Despite its huge impact on the health and socio-economic burden of the society, it remains a neglected tropical disease, with limited attention from governments and stakeholders in healthcare. One of the critical areas that is hugely under-developed is the development of accurate diagnostics for both intestinal and urogenital schistosomiasis. Diagnosis of schistosomiasis is important for the detection and treatment of disease in endemic and non-endemic settings. A conclusive detection method is also an indispensable part of treatment, both in the clinic and during mass drug administration (MDA), for the monitoring efficacy of treatment. Here, we review the available diagnostic methods and discuss the challenges encountered in diagnosis in resource limited settings. We also present the available diagnostics and cost implications for deployment in resource limited settings. Lastly, we emphasize the need for more funding directed towards the development of affordable diagnostic tools that is affordable for endemic countries as we work towards the elimination of the disease.