Institution
University of Nigeria, Nsukka
Education•Nsukka, Nigeria•
About: University of Nigeria, Nsukka is a education organization based out in Nsukka, Nigeria. It is known for research contribution in the topics: Population & Health care. The organization has 10211 authors who have published 13685 publications receiving 138922 citations.
Topics: Population, Health care, Public health, Malaria, Igbo
Papers published on a yearly basis
Papers
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TL;DR: A Science/Technology Park will gradually be formed as a functional part of PIAS, and it will be a joint-stock corporation with a sphere of interest compatible with PIAS activities.
48 citations
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TL;DR: In this article, the agronomic potential of brewers' spent grains (BSG) was evaluated on two texturally contrasting tropical soils, using a split-plot design with three replications.
48 citations
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TL;DR: The results of this study reveal a possible herb-drug interaction involving HCT and HSE, used as an ingredient in medicinal or refreshing drinks in many countries.
Abstract: Decoctions of Hibiscus sabdariffa L. (Family Malvaceae) are very popular for the preparation of homemade refreshing drinks and are also used medicinally for a variety of ailments. Particularly remarkable are the various scientific reports supporting diuretic and antihypertensive potentials. It is therefore not unusual for patients who are on orthodox antihypertensive medications to use medicinal H. sabdariffa drinks concomitantly without regard to the possibility of herb-drug interactions. This possibility necessitated this study in which the pharmacokinetic and pharmacodynamic interactions of H. sabdariffa extract (HSE) and hydrochlorothiazide (HCT), a commonly prescribed diuretic drug, were examined. The effects of concomitant administration of HSE on urine volume, urine pH, and urinary concentrations of sodium, bicarbonate, and chloride ions, as well as on the pharmacokinetic parameters of HCT, were determined in experimental rats and rabbits. Co-administration of HSE with HCT caused a significant increase in the volume of urine excreted and resulted in a decrease in the pH of urine and the concentrations of sodium, bicarbonate, and chloride ions. Co-administration of HSE (20-40 mg/kg) with HCT (10 mg/kg) increased and prolonged the plasma concentration, the mean area under the concentration-time curve, and the volume of distribution of HCT achieved over the 24-hour sampling period. The plasma clearance and the elimination rate constant of HCT decreased with increasing dose of HSE co-administered with the HCT. The results of this study reveal a possible herb-drug interaction involving HCT and HSE, used as an ingredient in medicinal or refreshing drinks in many countries.
48 citations
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TL;DR: The results insinuate that vanillin and vanillic acid confer a neuroprotective effect on oxidative brain damage, when vanillin being the most potent.
Abstract: The therapeutic effect of phenolics on neurodegenerative diseases has been attributed to their potent antioxidant properties. In the present study, the neuroprotective activities of vanillin and vanillic acid were investigated in Fe2+- induced oxidative toxicity in brain tissues by investigating their therapeutic effects on oxidative imbalance, cholinergic and nucleotide-hydrolyzing enzymes activities, dysregulated metabolic pathways. Their cytotoxicity was investigated in hippocampal neuronal cell lines (HT22). The reduced glutathione level, SOD and catalase activities were ameliorated in tissues treated with the phenolics, with concomitant depletion of malondialdehyde and nitric oxide levels. They inhibited acetylcholinesterase and butyrylcholinesterase activities, while concomitantly elevated ATPase activity. Treatment with vanillin led to restoration of oxidative-depleted metabolites and reactivation of the pentose phosphate and purine metabolism pathways, with concomitant activation of pathways for histidine and selenoamino metabolisms. While vanillic acid restored and reactivated oxidative-depleted metabolites and pathways but did not activate any additional pathway. Both phenolics portrayed good binding affinity for catalase, with vanillic acid having the higher binding energy of −7.0 kcal/mol. Both phenolics were not cytotoxic on HT22 cells, and their toxicity class were predicted to be 4. Only vanillin was predicted to be permeable across the blood brain barrier (BBB). These results insinuate that vanillin and vanillic acid confer a neuroprotective effect on oxidative brain damage, when vanillin being the most potent.
48 citations
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TL;DR: An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile and the results suggest the involvement of calcium in the mechanisms of the spasmogenic and vasoconstrictor actions.
Abstract: An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 microg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.
47 citations
Authors
Showing all 10333 results
Name | H-index | Papers | Citations |
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Kamyar Kalantar-Zadeh | 118 | 1025 | 56187 |
Peter J. Houghton | 63 | 228 | 14321 |
Alessandro Piccolo | 62 | 284 | 14332 |
R. W. Guillery | 60 | 106 | 13439 |
Ulrich Klotz | 56 | 213 | 10774 |
Nicholas H. Oberlies | 52 | 262 | 9683 |
Brian Norton | 49 | 322 | 9251 |
Adesola Ogunniyi | 47 | 272 | 11806 |
Obinna Onwujekwe | 43 | 282 | 8960 |
Sanjay Batra | 39 | 329 | 7179 |
Benjamin Uzochukwu | 38 | 163 | 9318 |
Christian N. Madu | 36 | 134 | 5378 |
Jude U. Ohaeri | 36 | 121 | 3088 |
Peter A. Akah | 33 | 164 | 3422 |
Charles E. Chidume | 33 | 153 | 3639 |