University of Nigeria, Nsukka

About: University of Nigeria, Nsukka is a education organization based out in Nsukka, Nigeria. It is known for research contribution in the topics: Population & Health care. The organization has 10211 authors who have published 13685 publications receiving 138922 citations.

Obstructive sleep apnea hypopnea syndrome

Abstract: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an important medical condition which is on the increase in the past 50 years. It causes significant morbidity and mortality in both developed and developing nations of the world. To review the relevant literature on obstructive sleep apnea. Literature review was carried out on the pathophysiology, clinical presentation, complications, diagnostic modalities, and treatment using computerized search. Additional information was obtained by cross referencing and using texts and journals in the medical libraries of Federal Medical Centre Owerri and University of Nigeria, Enugu. Most of the literature was from developed countries, with very few reports from Africa. Comprehensive management plan was lacking in many textbooks. OSAHS is an increasing medical and, more importantly, respiratory condition across the world. Early recognition and prompt appropriate intervention measures will reduce the mortality and improve the quality of life in patients with such conditions.

Biosynthesis of iron oxide nanoparticles via a composite of Psidium guavaja-Moringa oleifera and their antibacterial and photocatalytic study

Abstract: Human pathogenic diseases are on the rampage in the list of debilitating diseases globally. The endless quest to salvage this menace through various therapies via innocuous agents is essential to overcome these drug-resistant pathogens. This study engaged a benign, facile, biocompatible, cost-effective and eco-friendly approach to synthesized iron oxide nanoparticles (FeO-NPs) via a composite of Psidium guavaja-Moringa oleifera (PMC) leaf extract to address six most debilitating bacterial strain in vitro as an antibacterial agent. Physicochemical analysis of PMC formed nanoparticles (PMC_NPs) was effectuated through Fourier Transform Infrared Spectroscopy (FT-IR), UV–Visible Spectroscopy, X-ray Diffraction Spectroscopy (XRD), Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM). The PMC_NPs inhibited the growth of six human pathogens with higher activity at lower concentrations. It is noteworthy from our observations that, the bacterial strains show functional susceptibility to the PMC_NPs at lower concentrations compared to the orthodox antibacterial drugs. Photocatalytic degradation was observed with a decrease in the absorbance of Methylene blue dyes with the help of PMC_NPs apropos irradiation time under visible light irradiation. Consequently, PMC_NPs serve as an enhanced substitute for the orthodox antibacterial drugs in therapeutic biomedical field sequel to its pharmacodynamics against the bacterial strains at lower concentrations and also serves as a good component for water purification.

Renewable energy, urbanization, and ecological footprint linkage in CIVETS.

Abstract: Emerging economies are mostly plague by a massive consumption of non-renewable energy amidst an ever inceasing urbanization rate with little or no attention to the quality of the environmental. As such, this paper investigates the relationship between renewable energy, urbanization, economic growth, trade openness, and ecological footprint in CIVETS countries, namely, Colombia, Indonesia, Vietnam, Egypt, Turkey, and South Africa. The study employs augmented mean group estimator, panel cointegration, and causality tests. The findings reveal that renewable energy improves environmental quality, and trade is not particularly harmful to the environment. However, non-renewable energy consumption and urbanization are the chief contributors to environmental degradation in the CIVETS countries. Economic expansion mitigates environmental deterioration in Colombia, South Africa, and Turkey, but contributes to pollution in Egypt, Indonesia, and Vietnam. Finally, the causality test suggests that urbanization drives environmental degradation. Policy directions are discussed.

Myristoylation: An Important Protein Modification in the Immune Response.

Abstract: Increasing biochemical and genetic evidence confirms that myristoylation is an evolutionary conserved process of lipid modification in many eukaryotic and viral proteins. The discovery that the N-terminal blocking group of cyclic AMP-dependent protein kinase is a myristic acid, some 33 years ago, led to the birth of the field of ‘myristoylation’, dedicated to understanding the significance of protein myristoylation. Although the field is in its infancy, an increasing number of studies have appeared addressing the mechanisms and significance of N-myristoylation in various aspects of cellular signaling. N-Myristoylation is known to occur in mammalian, plant, viral and fungal proteins. Many proteins involved in a variety of signal cascades and cellular differentiation are myristoylated. These include the catalytic subunit of cAMP-dependent protein kinase, the β-subunit of calcineurin, the α-subunit of several G-proteins, the cellular and transforming forms of pp60src. Given the indispensible role of myristoylation in cellular functions, in this review, we examine the myriad functional implications of myristoylation with respect to immune function and regulation.