Institution
University of Nigeria, Nsukka
Education•Nsukka, Nigeria•
About: University of Nigeria, Nsukka is a education organization based out in Nsukka, Nigeria. It is known for research contribution in the topics: Population & Health care. The organization has 10211 authors who have published 13685 publications receiving 138922 citations.
Topics: Population, Health care, Public health, Malaria, Igbo
Papers published on a yearly basis
Papers
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TL;DR: A rare protective allele at LOXL1 is identified through deep resequencing of XFS cases and controls and a potential role for naturally occurring rare LO XL1 variants in disease biology is highlighted.
Abstract: Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results across populations, and to identify new variants associated with XFS We identified a rare protective allele at LOXL1 (pPhe407, odds ratio (OR) = 25, P = 29 × 10-14) through deep resequencing of XFS cases and controls from nine countries A genome-wide association study (GWAS) of XFS cases and controls from 24 countries followed by replication in 18 countries identified seven genome-wide significant loci (P < 5 × 10-8) We identified association signals at 13q12 (POMP), 11q233 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A) These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology
104 citations
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University of Cape Town1, University of Abuja2, North-West University3, National University of Rwanda4, Eduardo Mondlane University5, University of Nigeria, Nsukka6, University of Nairobi7, University of Khartoum8, Aga Khan University Hospital9, Medical Research Council10, University of London11, Imperial College London12
TL;DR: This PASCAR roadmap identifies practical and effective solutions that would improve detection, treatment and control of hypertension on the continent and could be implemented as is or adapted to specific national settings.
Abstract: Background The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority action to reduce heart disease and stroke on the continent. Objectives The aim of this PASCAR roadmap on hypertension was to develop practical guidance on how to implement strategies that translate existing knowledge into effective action and improve detection, treatment and control of hypertension and cardiovascular health in sub-Saharan Africa (SSA) by the year 2025. Methods Development of this roadmap started with the creation of a consortium of experts with leadership skills in hypertension. In 2014, experts in different fields, including physicians and nonphysicians, were invited to join. Via face-to-face meetings and teleconferences, the consortium made a situation analysis, set a goal, identified roadblocks and solutions to the management of hypertension and customized the World Heart Federation roadmap to Africa. Results Hypertension is a major crisis on the continent but very few randomized controlled trials have been conducted on its management. Also, only 25.8% of the countries have developed or adopted guidelines for management of hypertension. Other major roadblocks are either government and health-system related or health care professional or patient related. The PASCAR hypertension task force identified a 10-point action plan to be implemented by African ministries of health to achieve 25% control of hypertension in Africa by 2025. Conclusions Hypertension affects millions of people in SSA and if left untreated, is a major cause of heart disease and stroke. Very few SSA countries have a clear hypertension policy. This PASCAR roadmap identifies practical and effective solutions that would improve detection, treatment and control of hypertension on the continent and could be implemented as is or adapted to specific national settings.
103 citations
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TL;DR: The Nigerian medicinal plants’ antioxidant activity and lipid peroxidation inhibitory potencies correlated with their phenolic and flavonoid contents could be factors contributing substantially to their traditional medicinal use.
102 citations
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University of British Columbia1, Kuwait University2, Federal University of Pernambuco3, Katholieke Universiteit Leuven4, University of Nigeria, Nsukka5, King Saud University6, Redland Hospital7, Federal University of Rio Grande do Norte8, University of Saskatchewan9, Sahlgrenska University Hospital10, Rosalind Franklin University of Medicine and Science11, University of Utah12, American Physical Therapy Association13, Stellenbosch University14, Angelo State University15, Hong Kong Polytechnic University16, Eastern Washington University17, Leeds Beckett University18, University of Toronto19, University College Dublin20, Kathmandu21, Regis University22, University of Otago23, Singapore General Hospital24
TL;DR: A focus on clinical competencies associated with effective health education and health behavior change formulates the basis for The Second Physical Therapy Summit on Global Health.
Abstract: The First Physical Therapy Summit on Global Health was convened at the 2007 World Confederation for Physical Therapy (WCPT) Congress to vision practice in the 21st century and, in turn, entry-level education and research, as informed by epidemiological indicators, and consistent with evidence-based noninvasive interventions, the hallmark of physical therapy. The Summit and its findings were informed by WHO data and validated through national databases of the countries of the five WCPT regions. The health priorities based on mortality were examined in relation to proportions of physical therapists practicing in the areas of regional priorities and of the curricula in entry-level programs. As a validation check and to contextualize the findings, input from members of the 800 Summit participants was integrated and international consultants refined the recommendations. Lifestyle-related conditions (ischemic heart disease, smoking-related conditions, hypertension, stroke, cancer, and diabetes) were leading causes of premature death across regions. Contemporary definitions of physical therapy support that the profession has a leading role in preventing, reversing, as well as managing lifestyle-related conditions. The proportions of practitioners practicing primarily in these priority areas and of the entry-level curricula based on these priorities were low. The proportions of practitioners in priority areas and entry-level curricula devoted to lifestyle-related conditions warrant being better aligned with the prevalence of these conditions across regions in the 21st century. A focus on clinical competencies associated with effective health education and health behavior change formulates the basis for The Second Physical Therapy Summit on Global Health.
102 citations
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TL;DR: In this paper, it was proved that under suitable conditions on the real sequences {αn}n = 0∞ and {βn} n=0∞, the iteration process converges strongly to the unique solution of the equationTx=f.
102 citations
Authors
Showing all 10333 results
Name | H-index | Papers | Citations |
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Kamyar Kalantar-Zadeh | 118 | 1025 | 56187 |
Peter J. Houghton | 63 | 228 | 14321 |
Alessandro Piccolo | 62 | 284 | 14332 |
R. W. Guillery | 60 | 106 | 13439 |
Ulrich Klotz | 56 | 213 | 10774 |
Nicholas H. Oberlies | 52 | 262 | 9683 |
Brian Norton | 49 | 322 | 9251 |
Adesola Ogunniyi | 47 | 272 | 11806 |
Obinna Onwujekwe | 43 | 282 | 8960 |
Sanjay Batra | 39 | 329 | 7179 |
Benjamin Uzochukwu | 38 | 163 | 9318 |
Christian N. Madu | 36 | 134 | 5378 |
Jude U. Ohaeri | 36 | 121 | 3088 |
Peter A. Akah | 33 | 164 | 3422 |
Charles E. Chidume | 33 | 153 | 3639 |