Institution
University of Nigeria, Nsukka
Education•Nsukka, Nigeria•
About: University of Nigeria, Nsukka is a education organization based out in Nsukka, Nigeria. It is known for research contribution in the topics: Population & Health care. The organization has 10211 authors who have published 13685 publications receiving 138922 citations.
Topics: Population, Health care, Medicine, Public health, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors provide a critical review of aid data and place the resource intensity of current flows in crosscountry and intertemporal perspective, and introduce the concept of transactions intensity and show that by some measures, the management costs accompanying each dollar of aid to Africa are comparatively high.
68 citations
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TL;DR: Pregnant teenagers are at higher risk than their older counterparts, and female socioeducational development and proper use of contraceptive services will help reduce teenage pregnancy rate, while perinatal care will help to minimize it associated hazards.
Abstract: Context: Maternal age, parity, and socioeconomic class are important determinants of obstetric outcome of pregnancy. Teenage pregnancy constitutes a high risk pregnancy with complications arising from a combination of physiological, anatomical, and socioeconomic factors Objective: The objective was to determine the current incidence of all teenage pregnancies and their obstetric outcomes at UNTH, Enugu. Materials and Methods: This was a retrospective review of all teenage pregnancies at University of Nigeria Teaching Hospital, Enugu over a 6-year period (2000--2005). A total of 74 teenage pregnancies were analyzed and compared with 105 controls (adult mothers). Results: Records of 74 teenage pregnancies were identified within the study period which constitutes 1.67% of 4422 deliveries within the period. Majority of the teenagers (78.3%) were nulliparous. There was statistically significant differences between the teenage mothers and older mothers in the rate of unemployment (75.7% vs. 24.8%, P = 0.000), booking status (41.9% vs. 100%, P = 0.000) anemia (32.4% vs. 24.8%, P = 0.001), unsure of last menstrual period (32.4% vs. 15.2%, P = 0.007), caesarean section (18.9% vs. 10.5%, P = 0.000), cephalopelvic disproportion as an indication for caesarean section (9.4% vs. 3.8%, P = 0.001), preterm delivery (18.9% vs. 11.4%, P = 0.001), low birth weight (23.0% vs. 10.5%, P = 0.005), episiotomy (61.7% vs. 28.7%, P = 0.001), instrumental delivery (6.8% vs. 2.9% P = 0.001), Apgar score at 1 minute (35.1% vs. 19.1% P = 0.005), and perinatal mortality (16.2% vs. 12.4%). There were no maternal deaths. Conclusion: Pregnant teenagers are at higher risk than their older counterparts. Female socioeducational development and proper use of contraceptive services will help reduce teenage pregnancy rate, while perinatal care will help to minimize it associated hazards
68 citations
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TL;DR: A genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group, is reported and a locus, ZRANB3, is identified that is specific for this population is identified.
Abstract: Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10−9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations. Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.
68 citations
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TL;DR: The blood glucose reduction effect produced by the orally administered insulin-loaded microparticles prepared with three parts of sodium alginate and one part of mucin after 5h was, however, equal to thatproduced by the subcutaneously administered insulin solution, an indication that it is an effective alternative for the delivery of insulin.
68 citations
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TL;DR: It is concluded that advocacy and public health education is effective in increasing the commitment of policymakers to provide resources for implementing evidence-based maternal and child health services in Nigeria.
68 citations
Authors
Showing all 10333 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kamyar Kalantar-Zadeh | 118 | 1025 | 56187 |
Peter J. Houghton | 63 | 228 | 14321 |
Alessandro Piccolo | 62 | 284 | 14332 |
R. W. Guillery | 60 | 106 | 13439 |
Ulrich Klotz | 56 | 213 | 10774 |
Nicholas H. Oberlies | 52 | 262 | 9683 |
Brian Norton | 49 | 322 | 9251 |
Adesola Ogunniyi | 47 | 272 | 11806 |
Obinna Onwujekwe | 43 | 282 | 8960 |
Sanjay Batra | 39 | 329 | 7179 |
Benjamin Uzochukwu | 38 | 163 | 9318 |
Christian N. Madu | 36 | 134 | 5378 |
Jude U. Ohaeri | 36 | 121 | 3088 |
Peter A. Akah | 33 | 164 | 3422 |
Charles E. Chidume | 33 | 153 | 3639 |