University of North Carolina at Charlotte

About: University of North Carolina at Charlotte is a education organization based out in Charlotte, North Carolina, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 8772 authors who have published 22239 publications receiving 562529 citations. The organization is also known as: UNC Charlotte & UNCC.

Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis

Abstract: Cystic fibrosis (CF) clinical care guidelines exist for the care of infants up to age 2 years and for individuals ≥6 years of age. An important gap exists for preschool children between the ages of 2 and 5 years. This period marks a time of growth and development that is critical to achieve optimal nutritional status and maintain lung health. Given that disease often progresses in a clinically silent manner, objective and sensitive tools that detect and track early disease are important in this age group. Several challenges exist that may impede the delivery of care for these children, including adherence to therapies. A multidisciplinary committee was convened by the CF Foundation to develop comprehensive evidence-based and consensus recommendations for the care of preschool children, ages 2 to 5 years, with CF. This document includes recommendations in the following areas: routine surveillance for pulmonary disease, therapeutics, and nutritional and gastrointestinal care.

Real-Time Adaptive Motion Planning (RAMP) of Mobile Manipulators in Dynamic Environments With Unforeseen Changes

Abstract: This paper introduces a novel and general real-time adaptive motion planning (RAMP) approach suitable for planning trajectories of high-DOF or redundant robots, such as mobile manipulators, in dynamic environments with moving obstacles of unknown trajectories. The RAMP approach enables simultaneous path and trajectory planning and simultaneous planning and execution of motion in real time. It facilitates real-time optimization of trajectories under various optimization criteria, such as minimizing energy and time and maximizing manipulability. It also accommodates partially specified task goals of robots easily. The approach exploits redundancy in redundant robots (such as locomotion versus manipulation in a mobile manipulator) through loose coupling of robot configuration variables to best achieve obstacle avoidance and optimization objectives. The RAMP approach has been implemented and tested in simulation over a diverse set of task environments, including environments with multiple mobile manipulators. The results (and also the accompanying video) show that the RAMP planner, with its high efficiency and flexibility, not only handles a single mobile manipulator well in dynamic environments with various obstacles of unknown motions in addition to static obstacles, but can also readily and effectively plan motions for each mobile manipulator in an environment shared by multiple mobile manipulators and other moving obstacles.

Observation of nanojet-induced modes with small propagation losses in chains of coupled spherical cavities

Abstract: Nanojet-induced modes (NIMs) and their attenuation properties are studied in linear chains consisting of tens of touching polystyrene microspheres with sizes in the 2-10 μm range. To couple light to NIMs we used locally excited sources of light formed by several dye-doped fluorescent microspheres from the same chain of cavities. We directly observed the formation and propagation of NIMs by means of the scattering imaging technique. By measuring attenuation at long distances from the source, we demonstrate propagation losses for NIMs as small as 0.5dB per sphere.

Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis.

Abstract: Staphylococcus aureus is the bacterial pathogen which is responsible for approximately 80% of all cases of human osteomyelitis. It can invade and remain within osteoblasts. The fate of intracellular Staph. aureus after the death of the osteoblast has not been documented. We exposed human osteoblasts to Staph. aureus. After infection, the osteoblasts were either lysed with Triton X-100 or trypsinised. The bacteria released from both the trypsinised and lysed osteoblasts were cultured and counted. Colonies of the recovered bacteria were then introduced to additional cultures of human osteoblasts. The number of intracellular Staph. aureus recovered from the two techniques was equivalent. Staph. aureus recovered from time zero and 24 hours after infection, followed by lysis/trypsinisation, were capable of invading a second culture of human osteoblasts. Our findings indicate that dead or dying osteoblasts are capable of releasing viable Staph. aureus and that Staph. aureus released from dying or dead osteoblasts is capable of reinfecting human osteoblasts in culture.