University of North Carolina at Charlotte

About: University of North Carolina at Charlotte is a education organization based out in Charlotte, North Carolina, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 8772 authors who have published 22239 publications receiving 562529 citations. The organization is also known as: UNC Charlotte & UNCC.

Freeform optics for imaging

Abstract: In the last 10 years, freeform optics has enabled compact and high-performance imaging systems. This article begins with a brief history of freeform optics, focusing on imaging systems, including marketplace emergence. The development of this technology is motivated by the clear opportunity to enable science across a wide range of applications, spanning from extreme ultraviolet lithography to space optics. Next, we define freeform optics and discuss concurrent engineering that brings together design, fabrication, testing, and assembly into one process. We then lay out the foundations of the aberration theory for freeform optics and emerging design methodologies. We describe fabrication methods, emphasizing deterministic computer numerical control grinding, polishing, and diamond machining. Next, we consider mid-spatial frequency errors that inherently result from freeform fabrication techniques. We realize that metrologies of freeform optics are simultaneously sparse in their existence but diverse in their potential. Thus, we focus on metrology techniques demonstrated for the measurement of freeform optics. We conclude this review with an outlook on the future of freeform optics.

Multi-Label Classification of Emotions in Music

Abstract: This paper addresses the problem of multi-label classification of emotions in musical recordings. The testing data set contains 875 samples (30 seconds each). The samples were manually labelled into 13 classes, without limits regarding the number of labels for each sample. The experiments and test results are presented.

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15.

Abstract: Salp15 is an Ixodes scapularis salivary protein that inhibits CD4+ T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2 production. We show in this study that Salp15 binds specifically to the CD4 coreceptor on mammalian host T cells. Salp15 specifically associates through its C-terminal residues with the outermost two extracellular domains of CD4. Upon binding to CD4, Salp15 inhibits the subsequent TCR ligation-induced T cell signaling at the earliest steps including tyrosine phosphorylation of the Src kinase Lck, downstream effector proteins, and lipid raft reorganization. These results provide a molecular basis to understanding the immunosuppressive activity of Salp15 and its specificity for CD4+ T cells.