University of North Carolina at Charlotte

About: University of North Carolina at Charlotte is a education organization based out in Charlotte, North Carolina, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 8772 authors who have published 22239 publications receiving 562529 citations. The organization is also known as: UNC Charlotte & UNCC.

SPDA-CNN: Unifying Semantic Part Detection and Abstraction for Fine-Grained Recognition

Abstract: Most convolutional neural networks (CNNs) lack midlevel layers that model semantic parts of objects. This limits CNN-based methods from reaching their full potential in detecting and utilizing small semantic parts in recognition. Introducing such mid-level layers can facilitate the extraction of part-specific features which can be utilized for better recognition performance. This is particularly important in the domain of fine-grained recognition. In this paper, we propose a new CNN architecture that integrates semantic part detection and abstraction (SPDACNN) for fine-grained classification. The proposed network has two sub-networks: one for detection and one for recognition. The detection sub-network has a novel top-down proposal method to generate small semantic part candidates for detection. The classification sub-network introduces novel part layers that extract features from parts detected by the detection sub-network, and combine them for recognition. As a result, the proposed architecture provides an end-to-end network that performs detection, localization of multiple semantic parts, and whole object recognition within one framework that shares the computation of convolutional filters. Our method outperforms state-of-theart methods with a large margin for small parts detection (e.g. our precision of 93.40% vs the best previous precision of 74.00% for detecting the head on CUB-2011). It also compares favorably to the existing state-of-the-art on finegrained classification, e.g. it achieves 85.14% accuracy on CUB-2011.

In vivo resuscitation, and virulence towards mice, of viable but nonculturable cells of Vibrio vulnificus.

Abstract: Vibrio vulnificus is an estuarine bacterium responsible for 95% of all seafood-related deaths in the United States. The bacterium occurs naturally in molluscan shellfish, and ingestion of raw oysters is typically the source of human infection. V. vulnificus is also known to enter a viable but nonculturable (VBNC) state, wherein the cells are no longer culturable on routine plating media but can be shown to remain viable. Whether or not this human pathogen remains virulent when entering the VBNC state has not been definitively demonstrated. In this study, the VBNC state was induced through a temperature downshift to 5 degrees C, with cells becoming nonculturable ( 10(5) cells in the VBNC state were present in the inoculum. Culturable cells of V. vulnificus, with identification confirmed through PCR, were recovered from the blood and peritoneal cavities of mice which had died from injections of cells present in the VBNC state for at least 3 days. Thus, our data suggest that cells of V. vulnificus remain virulent, at least for some time, when present in the VBNC state and are capable of causing fatal infections following in vivo resuscitation. Our studies also indicate, however, that virulence decreases significantly as cells enter the VBNC state, which may account, at least to some extent, for the decrease in infections caused by this bacterium during winter months.

Data, Information, and Knowledge in Visualization

Abstract: In visualization, we use the terms data, information and knowledge extensively, often in an interrelated context. In many cases, they indicate different levels of abstraction, understanding, or truthfulness. For example, "visualization is concerned with exploring data and information," "the primary objective in data visualization is to gain insight into an information space," and "information visualization" is for "data mining and knowledge discovery." In other cases, these three terms indicate data types, for instance, as adjectives in noun phrases, such as data visualization, information visualization, and knowledge visualization. These examples suggest that data, information, and knowledge could serve as both the input and output of a visualization process, raising questions about their exact role in visualization.

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

Abstract: Though gender-based differences in the development of protective or pathological adaptive host responses have been widely noted, it is becoming apparent that sex may also influence the early perception of microbial challenges and the generation of inflammatory immune responses. These differences may be due to the actions of reproductive hormones, and such a hypothesis is supported by the presence of receptors for these hormones in a variety of immune cell types. Androgens such as testosterone have been shown to decrease immune functions, including cytokine production. However, the mechanisms by which testosterone limits such responses remain undefined. In this study, we have investigated the acute effects of testosterone on the level of expression of a key trigger for inflammation and innate immunity, Toll-like receptor 4 (TLR4), on isolated mouse macrophages. We show that in vitro testosterone treatment of macrophages, generated in the absence of androgen, elicits a modest but significant decrease in TLR4 expression and sensitivity to a TLR4-specific ligand. In addition, we have studied the effect of in vivo removal of endogenous testosterone on TLR4 expression and endotoxin susceptibility. We report that orchidectomized mice were significantly more susceptible to endotoxic shock and show that macrophages isolated from these animals have significantly higher TLR4 cell surface expression than those derived from sham gonadectomized mice. Importantly, these effects were not apparent in orchidectomized animals that received exogenous testosterone treatment. As such, these data may represent an important mechanism underlying the immunosuppressive effects of testosterone.

The Challenges of Reusing Mining and Mineral-Processing Wastes

Abstract: Mining and mineral-processing wastes are one of the world’s largest chronic waste concerns. Their reuse should be included in future sustainable development plans, but the potential impacts on a number of environmental processes are highly variable and must be thoroughly assessed. The chemical composition and geotechnical properties of the source rock determine which uses are most appropriate and whether reuse is economically feasible. If properly evaluated, mining waste can be reused to reextract minerals, provide additional fuel for power plants, supply construction materials, and repair surface and subsurface land structures altered by mining activities themselves.