Institution
University of North Carolina at Greensboro
Education•Greensboro, North Carolina, United States•
About: University of North Carolina at Greensboro is a education organization based out in Greensboro, North Carolina, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 5481 authors who have published 13715 publications receiving 456239 citations. The organization is also known as: UNCG & UNC Greensboro.
Papers published on a yearly basis
Papers
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TL;DR: In a nationally representative sample of US veterans, the prevalence of lifetime and current PTSD was 8.0% and 4.8%, respectively, and PTSD was associated with elevated risk for several psychiatric conditions and suicidality.
Abstract: OBJECTIVE: To describe the prevalence of posttraumatic stress disorder (PTSD) and comorbid psychiatric disorders and identify correlates of PTSD in a contemporary, nationally representative sample of US veterans. METHOD: Data were analyzed from Wave 1 of the National Health and Resilience in Veterans Study, a cross-sectional, retrospective, web-based survey of a population-based sample of 3,157 US veterans conducted between October and December 2011. The main outcome measure was probable lifetime PTSD, which was assessed by using a DSM-IV version of the PTSD Checklist (PCL), the PCL-Specific Stressor version. RESULTS: The weighted lifetime and current prevalence of probable PTSD was 8.0% (standard error [SE] = 0.48) and 4.8% (SE = 0.40), respectively. 87.0% of veterans reported exposure to at least 1 potentially traumatic event (PTE); veterans reported a mean of 3.4 (SD = 2.8) different PTE types in their lifetime. Sudden death of a loved one was the most frequently endorsed PTE (61.3%), and sexual abuse in adulthood had the highest conditional probability of PTSD (37.3%). PTSD was associated with increased odds of mood, anxiety, and substance use disorders (odds ratios [ORs] = 2.2-19.1, P values CONCLUSIONS: In a nationally representative sample of US veterans, the prevalence of lifetime and current PTSD was 8.0% and 4.8%, respectively, and PTSD was associated with elevated risk for several psychiatric conditions and suicidality. Veterans reported exposure to many PTE types in addition to combat, and conditional risk for PTSD was high for noncombat-related trauma. Prevention and treatment efforts designed to bolster protective psychosocial factors may help mitigate PTSD risk in this population. Language: en
220 citations
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TL;DR: A review of the recent developments and how integrated, large-scale investigations may overcome contemporary challenges in G × E research can be found in this paper, drawing on the example of a large, international, multi-center study into the identification and translational application of gene-environment interactions in schizophrenia.
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
220 citations
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TL;DR: It is shown that engineering a hairpin secondary structure onto the spacer region of single guide RNAs (hp-sgRNAs) can increase specificity by several orders of magnitude when combined with various CRISPR effectors.
Abstract: CRISPR (clustered regularly interspaced short palindromic repeat) systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy. In some cases, these bacterial nucleases have demonstrated off-target activity. This creates a potential hazard for therapeutic applications and could confound results in biological research. Therefore, improving the precision of these nucleases is of broad interest. Here we show that engineering a hairpin secondary structure onto the spacer region of single guide RNAs (hp-sgRNAs) can increase specificity by several orders of magnitude when combined with various CRISPR effectors. We first demonstrate that designed hp-sgRNAs can tune the activity of a transactivator based on Cas9 from Streptococcus pyogenes (SpCas9). We then show that hp-sgRNAs increase the specificity of gene editing using five different Cas9 or Cas12a variants. Our results demonstrate that RNA secondary structure is a fundamental parameter that can tune the activity of diverse CRISPR systems.
219 citations
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TL;DR: This article examined the importance of early social boldness and wariness as attributes that predict children's behavior in kindergarten and found that children identified early as socially bold showed more off-task behavior and were more likely to talk and make requests of the teacher in large-group classroom settings.
218 citations
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TL;DR: This article found that men who were physically punished, sexually abused, or who witnessed domestic violence in childhood were at greater risk for sexual perpetration in high school, and men who perpetrated sexual violence at home were at higher risk for perpetrating sexual violence in college.
Abstract: Three incoming freshmen classes of men provided data in a 5-year longitudinal study of the relationship between childhood victimization experiences and sexually coercive behaviors during adolescence and 4 years of college. A key finding of this study was that men who were physically punished, sexually abused, or who witnessed domestic violence in childhood were at greater risk for sexual perpetration in high school. Furthermore, men who perpetrated in high school were at greater risk for sexual perpetration in college; and after controlling for perpetration in high school, those who were abused or witnessed violence in childhood were not at greater risk for college perpetration. The findings have a number of implications for research and practice: We need to identify high-risk populations and direct more targeted interventions toward them. These groups include those who witness or experience abuse as a child and young men who perpetrate violence in adolescence, regardless of childhood abuse experiences.
217 citations
Authors
Showing all 5571 results
Name | H-index | Papers | Citations |
---|---|---|---|
Douglas E. Soltis | 127 | 612 | 67161 |
John C. Wingfield | 122 | 509 | 52291 |
Laurence Steinberg | 115 | 403 | 70047 |
Patrick Y. Wen | 109 | 838 | 52845 |
Mark T. Greenberg | 107 | 529 | 49878 |
Steven C. Hayes | 106 | 450 | 51556 |
Edward McAuley | 105 | 451 | 45948 |
Roberto Cabeza | 94 | 252 | 36726 |
K. Ranga Rama Krishnan | 90 | 299 | 26112 |
Barry J. Zimmerman | 88 | 177 | 56011 |
Michael K. Reiter | 84 | 380 | 30267 |
Steven R. Feldman | 83 | 1227 | 37609 |
Charles E. Schroeder | 82 | 234 | 26466 |
Dale H. Schunk | 81 | 162 | 45909 |
Kim D. Janda | 79 | 731 | 26602 |