University of North Texas

About: University of North Texas is a education organization based out in Denton, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 11866 authors who have published 26984 publications receiving 705376 citations. The organization is also known as: Fight, North Texas & UNT.

The urokinase plasminogen activator system in cancer: implications for tumor angiogenesis and metastasis.

Abstract: Substantial evidence exists which implicates the urokinase plasminogen activator system [urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1)] in the neo-vascularization, invasion and metastasis of many solid tumors Clinical studies have demonstrated an association between high levels of expression of the components of this system in tumors and poor patient prognosis and outcome Components of the uPA/uPAR system are differentially expressed or activated on motile cells including invading tumor cells and leukocytes, and migrating endothelial cells In contrast, there is little or no expression on most normal, quiescent cells Studies performed in vitro have demonstrated the regulation of the expression of uPA and uPAR by growth and differentiation factors as well as by oncogenes In this review, we summarize recent findings on the role of the components of the uPA/uPAR system in angiogenesis, invasiveness and tumor metastasis The activities of this system in endothelial and leukocyte cell biology and the relevance of these activities to angiogenesis and tumor metastasis will be considered Recent experimental evidence obtained using inhibitors of uPA and uPAR has validated this system as a therapeutic target for the development of anti-angiogenic and anti-metastatic therapeutic agents These studies, as well as additional therapeutic and diagnostic implications for uPAR targeting, will be discussed

Contribution of energy systems during a Wingate power test.

Abstract: Six men performed a total of 23 modified Wingate power tests against 5.5 kp (53.9 N) resistance on a Monark 864 ergometer. Breath-by-breath VO2 was measured using a SensorMedics 4400 metabolic cart. Peak anaerobic power (highest 5 s; mean(s.e.m.)) was 819(16) W (11.1(0.6) W kg-1) and anaerobic capacity (work in 30 s; mean(s.e.m.)) was 18.2(0.2) kJ (248(11) J kg-1). Contributions of ATP-PC, glycolytic and aerobic systems each 5 s were estimated. ATP-PC power (mean(s.e.m.)) peaked at 750(14) W (10.2(0.6) W kg-1) in the first 5 s; glycolytic power (mean(s.e.m.] peaked at 497(11) W (6.8(0.7) W kg-1) between 10 and 15 s into the test; aerobic power (mean(s.e.m.)) peaked at 157(5) W (2.1(0.3) W kg-1) during the last 5 s of the test, and VO2 exceeded 90% VO2peak Over the entire 30 s, aerobic contribution was 16%, glycolytic contribution was 56%, and ATP-PC contribution was 28%. It is concluded that glycolytic power peaks within the first 15 s of high power exercise; also, aerobic metabolism responds quickly during 'anaerobic' exercise and makes a significant contribution to the work performed.