Institution
University of North Texas
Education•Denton, Texas, United States•
About: University of North Texas is a education organization based out in Denton, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 11866 authors who have published 26984 publications receiving 705376 citations. The organization is also known as: Fight, North Texas & UNT.
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that exposing cells to MWCNOs and MWCNTs at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, and promoter analysis of the microarray results demonstrate that interferon and p38/ERK-MAPK cascades are critical pathway components in the induced signal transduction contributing to the more adverse effects observed upon exposure to M WCNTs.
Abstract: The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Although both fullerene and carbon nanotubes have been demonstrated to accumulate to cytotoxic levels within organs of various animal models and cell types and carbon nanomaterials have been exploited for cancer therapies, the molecular and cellular mechanisms for cytotoxicity of this class of nanomaterial are not yet fully apparent. To address this question, we have performed whole genome expression array analysis and high content image analysis based phenotypic measurements on human skin fibroblast cell populations exposed to multiwall carbon nano-onions (MWCNOs) and multiwall carbon nanotubes (MWCNTs). Here we demonstrate that exposing cells to MWCNOs and MWCNTs at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis. Expression array analysis indicates that multiple cellular pathways are perturbed after exposure to these nanomaterials at these doses, with material-specific toxigenomic profiles observed. Moreover, there are also distinct qualitative and quantitative differences in gene expression profiles, with each material at different dosage levels (6 and 0.6 microg/mL for MWCNO and 0.6 and 0.06 microg/mL for MWCNT). MWCNO and MWCNT exposure activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. MWCNTs induce genes indicative of a strong immune and inflammatory response within skin fibroblasts, while MWCNO changes are concentrated in genes induced in response to external stimuli. Promoter analysis of the microarray results demonstrate that interferon and p38/ERK-MAPK cascades are critical pathway components in the induced signal transduction contributing to the more adverse effects observed upon exposure to MWCNTs as compared to MWCNOs.
511 citations
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SupAgro1, New York University2, University of California, San Diego3, Agro ParisTech4, University of North Texas5, Lancaster University6, University of Missouri7, University of Würzburg8, Chinese Academy of Sciences9, University of Copenhagen10, University of Vermont11, University of Angers12, University of Bern13, Academia Sinica14
TL;DR: The phylogenetic tree was used to determine a unified nomenclature of this family named NPF, for NRT1/PTR FAMILY, and it is proposed that the members should be named accordingly: NPFX.
510 citations
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01 Aug 2014
TL;DR: This year, the participants were challenged with new data sets for English, as well as the introduction of Spanish, as a new language in which to assess semantic similarity, and the annotations for both tasks leveraged crowdsourcing.
Abstract: In Semantic Textual Similarity, systems rate the degree of semantic equivalence between two text snippets. This year, the participants were challenged with new data sets for English, as well as the introduction of Spanish, as a new language in which to assess semantic similarity. For the English subtask, we exposed the systems to a diversity of testing scenarios, by preparing additional OntoNotesWordNet sense mappings and news headlines, as well as introducing new genres, including image descriptions, DEFT discussion forums, DEFT newswire, and tweet-newswire headline mappings. For Spanish, since, to our knowledge, this is the first time that official evaluations are conducted, we used well-formed text, by featuring sentences extracted from encyclopedic content and newswire. The annotations for both tasks leveraged crowdsourcing. The Spanish subtask engaged 9 teams participating with 22 system runs, and the English subtask attracted 15 teams with 38 system runs.
509 citations
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TL;DR: In this article, edge-selectively sulfurized graphene nanoplatelets (SGnP) are synthesized as efficient metal-free electrocatalysts for cathodic oxygen reduction reaction (ORR).
Abstract: To replace precious platinum (Pt)-based electrocatalysts for cathodic oxygen reduction reaction (ORR), edge-selectively sulfurized graphene nanoplatelets (SGnP) are synthesized as efficient metal-free electrocatalysts simply by ball-milling pristine graphite in the presence of sulfur (S8 ). The resultant SGnPs exhibit remarkable electrocatalytic activity toward ORR with better tolerance to methanol crossover/CO poisoning effects and longer-term stability than those of pristine graphite and commercial Pt/C electrocatalysts. Edge-Selectively Sulfurized Graphene Nanoplatelets as Efficient Metal-Free Electrocatalysts for Oxygen Reduction Reaction: The Electron Spin Effect.
506 citations
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TL;DR: A class of environmentally responsive materials based on the spatial modulation of the chemical nature of gels is proposed and demonstrated here and has an internally heterogeneous or modulated structure.
Abstract: A class of environmentally responsive materials based on the spatial modulation of the chemical nature of gels is proposed and demonstrated here. The modulation was achieved by limiting the interpenetration of part of one gel network with another gel network. The gels so produced have an internally heterogeneous or modulated structure. Three simple applications based on the modulated gels are described here: a bigel strip, a shape memory gel, and a gel "hand." The bigel strip bends almost to a circle in response to a temperature increase or an increase in solvent concentration. The shape memory gel changes its shape from a straight line to a pentagon to a quadrangle as the temperature increases. These transitions from one shape to another are reversible. The gel "hand" in water can grasp or release an object simply by an adjustment of the temperature.
506 citations
Authors
Showing all 12053 results
Name | H-index | Papers | Citations |
---|---|---|---|
Steven N. Blair | 165 | 879 | 132929 |
Scott D. Solomon | 137 | 1145 | 103041 |
Richard A. Dixon | 126 | 603 | 71424 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Hong-Cai Zhou | 114 | 489 | 66320 |
Qian Wang | 108 | 2148 | 65557 |
Boris I. Yakobson | 107 | 443 | 45174 |
J. N. Reddy | 106 | 926 | 66940 |
David Spiegel | 106 | 733 | 46276 |
Charles A. Nelson | 103 | 557 | 40352 |
Robert J. Vallerand | 98 | 301 | 41840 |
Gerald R. Ferris | 93 | 332 | 29478 |
Michael H. Abraham | 89 | 726 | 37868 |
Jere H. Mitchell | 88 | 337 | 24386 |
Alan Needleman | 86 | 373 | 39180 |