University of Notre Dame

About: University of Notre Dame is a education organization based out in Notre Dame, Indiana, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 22238 authors who have published 55201 publications receiving 2032925 citations. The organization is also known as: University of Notre Dame du Lac & University of Notre Dame, South Bend.

Textual Analysis in Accounting and Finance: A Survey

Abstract: Relative to quantitative methods traditionally used in accounting and finance, textual analysis is substantially less precise Thus, understanding the art is of equal importance to understanding the science In this survey we describe the nuances of the method and, as users of textual analysis, some of the tripwires in implementation We also review the contemporary textual analysis literature and highlight areas of future research

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.

Abstract: Activated protein C (APC) is a systemic anti-coagulant and anti-inflammatory factor1,2,3. It reduces organ damage in animal models of sepsis, ischemic injury and stroke1,4,5 and substantially reduces mortality in patients with severe sepsis6. It was not known whether APC acts as a direct cell survival factor or whether its neuroprotective effect5,7 is secondary to its anti-coagulant and anti-inflammatory effects1,2,3. We report that APC directly prevents apoptosis in hypoxic human brain endothelium through transcriptionally dependent inhibition of tumor suppressor protein p53, normalization of the pro-apoptotic Bax/Bcl-2 ratio and reduction of caspase-3 signaling. These mechanisms are distinct from those involving upregulation of the genes encoding the anti-apoptotic Bcl-2 homolog A1 and inhibitor of apoptosis protein-1 (IAP-1) by APC in umbilical vein endothelial cells8,9. Cytoprotection of brain endothelium by APC in vitro required endothelial protein C receptor (EPCR) and protease-activated receptor-1 (PAR-1), as did its in vivo neuroprotective activity in a stroke model of mice with a severe deficiency of EPCR10. This is consistent with work showing the direct effects of APC on cultured cells via EPCR and PAR-1 (ref. 9). Moreover, the in vivo neuroprotective effects of low-dose mouse APC seemed to be independent of its anti-coagulant activity. Thus, APC protects the brain from ischemic injury by acting directly on brain cells.

Is the Ewald summation still necessary? Pairwise alternatives to the accepted standard for long-range electrostatics

Abstract: We investigate pairwise electrostatic interaction methods and show that there are viable computationally efficient (O(N)) alternatives to the Ewald summation for typical modern molecular simulations. These methods are extended from the damped and cutoff-neutralized Coulombic sum originally proposed by Wolf et al. [J. Chem. Phys. 110, 8255 (1999)]. One of these, the damped shifted force method, shows a remarkable ability to reproduce the energetic and dynamic characteristics exhibited by simulations employing lattice summation techniques. Comparisons were performed with this and other pairwise methods against the smooth particle-mesh Ewald summation to see how well they reproduce the energetics and dynamics of a variety of molecular simulations.

Stability of model-based networked control systems with time-varying transmission times

Abstract: In model-based networked control systems (MB-NCSs), an explicit model of the plant is used to produce an estimate of the plant state behavior between transmission times. In this paper, the stability of MB-NCSs is studied when the controller/actuator is updated with the sensor information at nonconstant time intervals. Networked control systems with transmission times that are varying either within a time interval or are driven by a stochastic process with identically independently distributed and Markov-chain driven transmission times are studied. Sufficient conditions for Lyapunov stability are derived. For stochastically modeled transmission times almost sure stability and mean-square sufficient conditions for stability are introduced.

Masses, Radii, and Orbits of Small Kepler Planets: The Transition From Gaseous to Rocky Planets

Abstract: We report on the masses, sizes, and orbits of the planets orbiting 22 Kepler stars. There are 49 planet candidates around these stars, including 42 detected through transits and 7 revealed by precise Doppler measurements of the host stars. Based on an analysis of the Kepler brightness measurements, along with high-resolution imaging and spectroscopy, Doppler spectroscopy, and (for 11 stars) asteroseismology, we establish low false-positive probabilities (FPPs) for all of the transiting planets (41 of 42 have an FPP under 1%), and we constrain their sizes and masses. Most of the transiting planets are smaller than three times the size of Earth. For 16 planets, the Doppler signal was securely detected, providing a direct measurement of the planet's mass. For the other 26 planets we provide either marginal mass measurements or upper limits to their masses and densities; in many cases we can rule out a rocky composition. We identify six planets with densities above 5 g cm(-3), suggesting a mostly rocky interior for them. Indeed, the only planets that are compatible with a purely rocky composition are smaller than similar to 2 R-circle plus. Larger planets evidently contain a larger fraction of low-density material (H, He, and H2O).