University of Notre Dame

About: University of Notre Dame is a education organization based out in Notre Dame, Indiana, United States. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 22238 authors who have published 55201 publications receiving 2032925 citations. The organization is also known as: University of Notre Dame du Lac & University of Notre Dame, South Bend.

Implications of Recent Developments in Structural Equation Modeling for Counseling Psychology

Abstract: We review recent developments in structural equation modeling (SEM) since Fassinger’s (1987) introductory article. We discuss issues critical to designing and evaluating SEM studies. Our review includes recent technological developments in SEM such as new approaches from hypothesis testing to determining statistical power and assessing model fit. Moreover, we discuss innovations in applying SEM to different research contexts and designs (e.g., experimental and longitudinal designs and interactions among latent variables). Finally, we discuss procedures for redressing common problems and misunderstandings in the application of SEM procedures to counseling research.

Computational Study of Metal Contacts to Monolayer Transition-Metal Dichalcogenide Semiconductors

Abstract: Modern electronics rely on semiconductors such as silicon. Researchers show how a new class of semiconductors---monolayer transition-metal dichalcogenides---can be optimized to improve device performance.

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells.

Abstract: Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus predominantly on targeting the proliferation of rapidly growing cancer epithelial cells. We know that this is largely ineffective with resistance arising in most tumors following exposure to chemotherapy. Despite the long-standing recognition of the prominence of CAFs in PDAC, the effect of chemotherapy on CAFs and how they may contribute to drug resistance in neighboring cancer cells is not well characterized. Here, we show that CAFs exposed to chemotherapy have an active role in regulating the survival and proliferation of cancer cells. We found that CAFs are intrinsically resistant to gemcitabine, the chemotherapeutic standard of care for PDAC. Further, CAFs exposed to gemcitabine significantly increase the release of extracellular vesicles called exosomes. These exosomes increased chemoresistance-inducing factor, Snail, in recipient epithelial cells and promote proliferation and drug resistance. Finally, treatment of gemcitabine-exposed CAFs with an inhibitor of exosome release, GW4869, significantly reduces survival in co-cultured epithelial cells, signifying an important role of CAF exosomes in chemotherapeutic drug resistance. Collectively, these findings show the potential for exosome inhibitors as treatment options alongside chemotherapy for overcoming PDAC chemoresistance.

Conceptualizing and Measuring Democracy: A New Approach

Abstract: InthewakeoftheColdWar,democracyhasgainedthestatusofamantra.Yetthereisnoconsensusabouthowtoconceptualizeand measure regimes such that meaningful comparisons can be made through time and across countries. In this prescriptive article, we argueforanewapproachtoconceptualizationandmeasurement.Wefirstreviewsomeoftheweaknessesamongtraditionalapproaches. Wethenlayoutourapproach,whichmaybecharacterizedas historical, multidimensional, disaggregated,and transparent.Weendby reviewing some of the payoffs such an approach might bring to the study of democracy.