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Institution

University of Nottingham

EducationNottingham, Nottingham, United Kingdom
About: University of Nottingham is a education organization based out in Nottingham, Nottingham, United Kingdom. It is known for research contribution in the topics: Population & Poison control. The organization has 54772 authors who have published 119600 publications receiving 4227408 citations. The organization is also known as: The University of Nottingham & University College, Nottingham.


Papers
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Journal ArticleDOI
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Abstract: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them. REM sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter activity on functional neuroimaging are given greater diagnostic weighting as features suggestive of a DLB diagnosis. The 1-year rule distinguishing between DLB and Parkinson disease with dementia may be difficult to apply in clinical settings and in such cases the term most appropriate to each individual patient should be used. Generic terms such as Lewy body (LB) disease are often helpful. The authors propose a new scheme for the pathologic assessment of LBs and Lewy neurites (LN) using alpha-synuclein immunohistochemistry and semiquantitative grading of lesion density, with the pattern of regional involvement being more important than total LB count. The new criteria take into account both Lewy-related and Alzheimer disease (AD)-type pathology to allocate a probability that these are associated with the clinical DLB syndrome. Finally, the authors suggest patient management guidelines including the need for accurate diagnosis, a target symptom approach, and use of appropriate outcome measures. There is limited evidence about specific interventions but available data suggest only a partial response of motor symptoms to levodopa: severe sensitivity to typical and atypical antipsychotics in ∼50%, and improvements in attention, visual hallucinations, and sleep disorders with cholinesterase inhibitors.

4,258 citations

Book ChapterDOI
TL;DR: In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP.
Abstract: ### A. Overview Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are important signaling molecules that mediate diverse biological effects via cell-surface receptors termed purine receptors. In this review particular emphasis is placed on the discrepancy between the

4,177 citations

Journal ArticleDOI
TL;DR: In this paper, an elementary account of several theoretical methods of attack is given, among them the derivation of inequalities between various moduli, and the approach is completely general and exact.
Abstract: The title problem concerns two isotropic phases firmly bonded together to form a mixture with any concentrations. An elementary account of several theoretical methods of attack is given, among them the derivation of inequalities between various moduli. The approach is completely general and exact. Additionally, the problem is fully solved when the phases have equal rigidities but different compressibilities, the geometry being entirely arbitrary.

4,141 citations

Journal ArticleDOI
TL;DR: Overall safety and tolerability was good with no change in the safety profile of pioglitazone identified; mortality rates from heart failure did not differ between groups.

3,899 citations

Journal ArticleDOI
TL;DR: In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Abstract: Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

3,726 citations


Authors

Showing all 55289 results

NameH-indexPapersCitations
Robert Langer2812324326306
Robert M. Califf1961561167961
Eric J. Topol1931373151025
Simon D. M. White189795231645
Douglas F. Easton165844113809
Elliott M. Antman161716179462
Pete Smith1562464138819
Christopher P. Cannon1511118108906
Scott T. Weiss147102574742
Frede Blaabjerg1472161112017
Martin J. Blaser147820104104
Stephen Sanders1451385105943
Stuart J. Pocock145684143547
Peter B. Jones145185794641
Alexander Belyaev1421895100796
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023214
2022877
20216,552
20206,421
20195,669
20185,273