Institution
University of Oklahoma
Education•Norman, Oklahoma, United States•
About: University of Oklahoma is a education organization based out in Norman, Oklahoma, United States. It is known for research contribution in the topics: Population & Radar. The organization has 25269 authors who have published 52609 publications receiving 1821706 citations. The organization is also known as: OU & Oklahoma University.
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TL;DR: This is the first study to identify aromatase expression mostly, if not entirely, in glial cells under normal rather than brain injury-dependent conditions, and may represent an adaptation linked to continual neurogenesis that is known to occur throughout an individual's lifetime among fishes.
Abstract: Although teleost fish have higher levels of brain aromatase activity than any other vertebrate group, its function remains speculative, and no study has identified its cellular basis. A previous study determined aromatase activity in a vocal fish, the plainfin midshipman ( Porichthys notatus ), and found highest levels in the telencephalon and lower levels in the sonic hindbrain, which was dimorphic between and within (males) sexes. We have now localized aromatase-containing cells in the midshipman brain both by immunocytochemistry using teleost-specific aromatase antibodies and by in situ hybridization using midshipman-specific aromatase probes. Aromatase-immuno-reactivity and mRNA hybridization signal are consistent with relative levels of aromatase activity in different brain regions: concentrated in the dimorphic sonic motor nucleus, in a band just beneath the periaqueductal gray in the midbrain, in ventricular regions in the hypothalamus, and highest levels in the telencephalon especially in preoptic and ventricular areas. Surprisingly, double-label immunofluorescence does not show aromatase-immunoreactive colocalization in neurons, but instead in radial glia throughout the brain. This is the first study to identify aromatase expression mostly, if not entirely, in glial cells under normal rather than brain injury-dependent conditions. The abundance of aromatase in teleosts may represent an adaptation linked to continual neurogenesis that is known to occur throughout an individual's lifetime among fishes. The localization of aromatase within the intersexually and intrasexually dimorphic vocal-motor circuit further implies a function in the expression of alternative male reproductive phenotypes and, more generally, the development of natural, individual variation of specific brain nuclei.
293 citations
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University of Chicago1, Tokyo University of Science2, National Institutes of Natural Sciences, Japan3, Rhode Island Hospital4, University of Michigan5, University of Angers6, Ealing Hospital7, University of Oklahoma8, University of Pennsylvania9, Johns Hopkins University10, Tottori University11, Eastern Virginia Medical School12, Stanford University13, University of Milan14, University of Turin15, Belfast Health and Social Care Trust16, François Rabelais University17, National University of Cuyo18
TL;DR: The group of phenotypes associated with ARX mutations demonstrates remarkable pleiotropy, but also comprises a nearly continuous series of developmental disorders that begins with hydranencephaly, lissencephally, and agenesis of the corpus callosum, and ends with a series of overlapping syndromes with apparently normal brain structure.
Abstract: We recently identified mutations of ARX in nine genotypic males with X-linked lissencephaly with abnormal genitalia (XLAG), and in several female relatives with isolated agenesis of the corpus callosum (ACC). We now report 13 novel and two recurrent mutations of ARX, and one nucleotide change of uncertain significance in 20 genotypic males from 16 families. Most had XLAG, but two had hydranencephaly and abnormal genitalia, and three males from one family had Proud syndrome or ACC with abnormal genitalia. We obtained detailed clinical information on all 29 affected males, including the nine previously reported subjects. Premature termination mutations consisting of large deletions, frameshifts, nonsense mutations, and splice site mutations in exons 1 to 4 caused XLAG or hydranencephaly with abnormal genitalia. Nonconservative missense mutations within the homeobox caused less severe XLAG, while conservative substitution in the homeodomain caused Proud syndrome. A nonconservative missense mutation near the C-terminal aristaless domain caused unusually severe XLAG with microcephaly and mild cerebellar hypoplasia. In addition, several less severe phenotypes without malformations have been reported, including mental retardation with cryptogenic infantile spasms (West syndrome), other seizure types, dystonia or autism, and nonsyndromic mental retardation. The ARX mutations associated with these phenotypes have included polyalanine expansions or duplications, missense mutations, and one deletion of exon 5. Together, the group of phenotypes associated with ARX mutations demonstrates remarkable pleiotropy, but also comprises a nearly continuous series of developmental disorders that begins with hydranencephaly, lissencephaly, and agenesis of the corpus callosum, and ends with a series of overlapping syndromes with apparently normal brain structure.
293 citations
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TL;DR: Results indicate that bone-like ECM synthesized in vitro can enhance the osteoblastic differentiation of MSCs, and the generation of osteoinductive matrix in vitro by culturing cell/scaffold constructs for tissue engineering applications.
293 citations
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TL;DR: Clostridium ljungdahlii is the first acetogen in clostridial 23S rRNA homology group I, and was isolated from chicken yard waste for its ability to produce ethanol from synthesis gas.
Abstract: Clostridium ljungdahlii sp. nov. strain ATCC 49587T (T = type strain) was isolated from chicken yard waste for its ability to produce ethanol from synthesis gas. This gram-positive, motile, sporeforming rod's metabolism was primarily acetogenic. C. ljungdahlii grew with carbon monoxide, hydrogen and carbon dioxide, ethanol, pyruvate, arabinose, xylose, fructose, or glucose. Methanol, ferulic acid, lactate, galactose, and mannose did not support growth. The G+C content was 22 to 23 mol%. C. ljungdahlii is the first acetogen in clostridial 23S rRNA homology group I.
292 citations
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TL;DR: In this paper, the authors examined the relation between legal risk and debt ownership structure in project finance loan tranches and found that the tranches exhibit high absolute levels of debt ownership concentration: the largest single bank holds 20.3% while the top five banks collectively hold 61.2% of a typical tranche.
Abstract: Using a sample of 495 project finance loan tranches (worth $151 billion) to borrowers in 61 different countries, we examine the relation between legal risk and debt ownership structure. The tranches exhibit high absolute levels of debt ownership concentration: the largest single bank holds 20.3% while the top five banks collectively hold 61.2% of a typical tranche. In countries with strong creditor rights and reliable legal enforcement, lenders create smaller and more concentrated syndicates to facilitate monitoring and low cost contracting. When lenders cannot rely on legal enforcement mechanisms to protect their claims, they create larger and more diffuse syndicates as a way to deter strategic default.
292 citations
Authors
Showing all 25490 results
Name | H-index | Papers | Citations |
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Ronald C. Kessler | 274 | 1332 | 328983 |
Michael A. Strauss | 185 | 1688 | 208506 |
Derek R. Lovley | 168 | 582 | 95315 |
Ashok Kumar | 151 | 5654 | 164086 |
Peter J. Schwartz | 147 | 647 | 107695 |
Peter Buchholz | 143 | 1181 | 92101 |
Robert Hirosky | 139 | 1697 | 106626 |
Elizabeth Barrett-Connor | 138 | 793 | 73241 |
Brad Abbott | 137 | 1566 | 98604 |
Lihong V. Wang | 136 | 1118 | 72482 |
Itsuo Nakano | 135 | 1539 | 97905 |
Phillip Gutierrez | 133 | 1391 | 96205 |
P. Skubic | 133 | 1573 | 97343 |
Elizaveta Shabalina | 133 | 1421 | 92273 |
Richard Brenner | 133 | 1108 | 87426 |