University of Oklahoma

About: University of Oklahoma is a education organization based out in Norman, Oklahoma, United States. It is known for research contribution in the topics: Population & Radar. The organization has 25269 authors who have published 52609 publications receiving 1821706 citations. The organization is also known as: OU & Oklahoma University.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Abstract: To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

A syndrome of infantilism, congenital webbed neck, and cubitus valgus1

Abstract: The triad, infantilism, webbing of the skin of the neck, and deformity of the elbow (cubitus valgus), occurring in the same individual is unusual, and, to my knowledge, has not been previously reported. It is sufficiently interesting to warrant this report, although the individual signs are perhaps not uncommon. Short neck, due to absence of the cervical spine, was first described by Klippel and Feil (1) in 1912. Only about 40 such cases have been reported to date, and these mostly in the French and German literature. A similar condition (pseudo-Klippel-Feil syndrome) (2) has been reported, in which there was a numerical variation in, and more or less complete fusion of, the cervical vertebrae. Webbing of the neck was first described by Kobylinski (3) in 1882, and its relation to congenital short neck was suggested by Darchter (4) in 1922.

The effectiveness of creativity training: A quantitative review

Abstract: Over the course of the last half century, numerous training programs intended to develop creativity capacities have been proposed. In this study, a quantitative meta‐analysis of program evaluation efforts was conducted. Based on 70 prior studies, it was found that well‐designed creativity training programs typically induce gains in performance with these effects generalizing across criteria, settings, and target populations. Moreover, these effects held when internal validity considerations were taken into account. An examination of the factors contributing to the relative effectiveness of these training programs indicated that more successful programs were likely to focus on development of cognitive skills and the heuristics involved in skill application, using realistic exercises appropriate to the domain at hand. The implications of these observations for the development of creativity through educational and training interventions are discussed along with directions for future research.

Tackling antibiotic resistance

Abstract: The development and spread of antibiotic resistance in bacteria is a universal threat to both humans and animals that is generally not preventable but can nevertheless be controlled, and it must be tackled in the most effective ways possible. To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011. From these discussions there emerged a priority list of steps that need to be taken to resolve this global crisis.

Workers, Wages, and Technology

Abstract: This paper documents how plant-level wages, occupational mix, workforce education, and productivity vary with the adoption and use of new factory automation technologies such as programmable controllers, computer-automated design, and numerically controlled machines. Our cross-sectional results show that plants that use a large number of new technologies employ more educated workers, employ relatively more managers, professionals, and precision-craft workers, and pay higher wages. However, our longitudinal analysis shows little correlation between skill upgrading and the adoption of new technologies. It appears that plants that adopt new factory automation technologies have more skilled workforces both pre- and postadoption.