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Institution

University of Oviedo

EducationOviedo, Spain
About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.


Papers
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Journal ArticleDOI
TL;DR: The pyrolysis of sewage sludge was studied in a microwave oven using graphite as microwave absorber and a conventional electrical furnace was employed in order to compare the results obtained with both methods.

164 citations

Journal ArticleDOI
TL;DR: In this paper, low and high frequency climatic fluctuations in northern Iberian Peninsula during the last glacial maximum (LGM) and deglaciation are documented in a stalagmite using δ18O and δ13C and hydrologically sensitive trace metal ratios Mg/Ca and Ba/Ca.

164 citations

Journal ArticleDOI
TL;DR: This review discusses the importance of AMPK activity for diverse aspects of cellular metabolism, and how AMPK modulates autophagic degradation and adapts it to cellular energetic status, and explains how AM PK-mediated signaling is mechanistically involved in autophagy regulation.
Abstract: Eukaryotic cells have developed mechanisms that allow them to link growth and proliferation to the availability of energy and biomolecules. AMPK (adenosine monophosphate-activated protein kinase) is one of the most important molecular energy sensors in eukaryotic cells. AMPK activity is able to control a wide variety of metabolic processes connecting cellular metabolism with energy availability. Autophagy is an evolutionarily conserved catabolic pathway whose activity provides energy and basic building blocks for the synthesis of new biomolecules. Given the importance of autophagic degradation for energy production in situations of nutrient scarcity, it seems logical that eukaryotic cells have developed multiple molecular links between AMPK signaling and autophagy regulation. In this review, we will discuss the importance of AMPK activity for diverse aspects of cellular metabolism, and how AMPK modulates autophagic degradation and adapts it to cellular energetic status. We will explain how AMPK-mediated signaling is mechanistically involved in autophagy regulation both through specific phosphorylation of autophagy-relevant proteins or by indirectly impacting in the activity of additional autophagy regulators.

164 citations

Journal ArticleDOI
TL;DR: No single mechanism emerges to explain these diverse effects of systemic Al on bone formation and remodeling and on hematopoietic tissue and on systemic Al and the kidney.
Abstract: Although the full mechanisms are not yet elucidated, research into the mechanism of toxicity of aluminum (Al) on bone formation and remodeling and on hematopoietic tissue is ongoing. In contrast little information exists on the interactive effects of systemic Al and the kidney. In bone, both clinically and experimentally, high doses of Al inhibit remodeling, slowing both osteoblast and osteoclast activities and producing osteomalacia and adynamic bone disease. In contrast, while very low levels of Al are mitogenic in bones of experimental animals, the effect of low levels of Al in humans is unknown. Aluminum has been shown to have its mitogenic action at the osteoblast, but whether the effect on resorption is viz osteoblast-directed changes in osteoclast activity has not yet been determined. Parathyroid hormone (PTH) levels are disrupted by Al in humans and animals. Whether altered PTH levels play a major or even a minor role in Al-dependent osteotoxicity requires clarification. In hematopoietic tissue, Al causes a microcytic anemia, not reversible by iron. Friend leukemia cells treated with Al have been reported to accumulate excess iron, without incorporating it into ferritin or heme. It is not yet known which steps in iron metabolism are disrupted by Al, if they involve a single mechanism of action, or even if this disruption in iron metabolism accounts for the anemia seen in Al toxicosis. In kidney, research is needed to evaluate Al nephrotoxicity; there are almost no studies in this area. Furthermore, research is needed to evaluate mechanisms of renal Al excretion, presently shown by one study to occur at the distal tubule. Such studies might well throw light on whether Al plays a role in aggravating renal insufficiency, or whether the role of the kidney in Al toxicosis is limited to the causative effect of renal compromise on Al accumulation. In summary, while a number of mechanisms have been proposed for the toxic action of Al, no single mechanism emerges to explain these diverse effects of systemic Al. Recommendations for future research are presented and summarized in Table 1.

164 citations

Journal ArticleDOI
TL;DR: The algorithm can be used with data from any Mobile Laser Scanning system, as it transforms the original point cloud and fits it into a regular grid, thus avoiding irregularities produced due to point density differences within the point cloud.
Abstract: An algorithm for automatic extraction of pole-like street furniture objects using Mobile Laser Scanner data was developed and tested The method consists in an initial simplification of the point cloud based on the regular voxelization of the space The original point cloud is spatially discretized and a version of the point cloud whose amount of data represents 20–30% of the total is created All the processes are carried out with the reduced version of the data, but the original point cloud is always accessible without any information loss, as each point is linked to its voxel All the horizontal sections of the voxelized point cloud are analyzed and segmented separately The two-dimensional fragments compatible with a section of a target pole are selected and grouped Finally, the three-dimensional voxel representation of the detected pole-like objects is identified and the points from the original point cloud belonging to each pole-like object are extracted The algorithm can be used with data from any Mobile Laser Scanning system, as it transforms the original point cloud and fits it into a regular grid, thus avoiding irregularities produced due to point density differences within the point cloud The algorithm was tested in four test sites with different slopes and street shapes and features All the target pole-like objects were detected, with the only exception of those severely occluded by large objects and some others which were either attached or too close to certain features

163 citations


Authors

Showing all 13643 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Carlo Rovelli1461502103550
J. González-Nuevo144500108318
German Martinez1411476107887
Roland Horisberger1391471100458
Francisco Herrera139100182976
Javier Cuevas1381689103604
Teresa Rodrigo1381831103601
L. Toffolatti13637695529
Elias Campo13576185160
Gabor Istvan Veres135134996104
Francisco Matorras134142894627
Joe Incandela134154993750
Nikhil C. Munshi13490667349
Luca Scodellaro134174198331
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202396
2022268
20211,825
20201,913
20191,806
20181,721