Institution
University of Oviedo
Education•Oviedo, Spain•
About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.
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TL;DR: An adverse outcome of COVID-19 was associated with male gender, hypertension, hypercholesterolemia and the ACE1 genotype, and the effect was dependent on the hypertensive status.
136 citations
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TL;DR: Deep eutetic solvents (DESs) are introduced as a green alternative media to carry out chemoselective additions of ketones in air at room temperature and suggest that a kinetic activation of the alkylating reagents is taking place, favoring nucleophilic addition over the competitive hydrolysis.
Abstract: Despite their enormous synthetic relevance, the use of polar organolithium and Grignard reagents is greatly limited by their requirements of low temperatures in order to control their reactivity as well as the need of dry organic solvents and inert atmosphere protocols to avoid their fast decomposition. Breaking new ground on the applications of these commodity organometallics in synthesis under more environmentally friendly conditions, this work introduces deep eutetic solvents (DESs) as a green alternative media to carry out chemoselective additions of ketones in air at room temperature. Comparing their reactivities in DES with those observed in pure water suggest that a kinetic activation of the alkylating reagents is taking place, favoring nucleophilic addition over the competitive hydrolysis, which can be rationalized through formation of halide-rich magnesiate or lithiate species.
136 citations
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TL;DR: For example, the authors found that polyspecific coccolith separates from core top sediments in the eastern equatorial Pacific show variations of ∼15% in the Sr/Ca ratios across the equatorial upwelling zone, with the highest at the equator and decreasing off-axis.
Abstract: [1] Polyspecific coccolith separates from core top sediments in the eastern equatorial Pacific show variations of ∼15% in Sr/Ca ratios across the equatorial upwelling zone, with Sr/Ca highest at the equator and decreasing off-axis. These variations cannot be due to changes in the Sr/Ca of seawater, which varies by less than 2% in the surface ocean. Variations in Sr/Ca of coccolith sediments are similar to variations in primary productivity and alkenone-estimated coccolithophorid growth rates in overlying surface waters and to CaCO3 rain rates measured in sediment traps. Because of these relationships and because calcification rate exerts a strong control on Sr/Ca in abiogenic calcites, we suggest that the observed Sr/Ca variations in coccoliths may be strongly controlled by coccolithophorid growth and calcification rates, although temperature may also influence coccolith Sr/Ca to a lesser degree. Changes in dissolution intensity and coccolith assemblages appear to exert a minor influence, if any, on coccolith Sr/Ca in these sediment core tops. If further work confirms relationships between coccolith Sr/Ca and coccolithophorid productivity, Sr/Ca records of past changes in coccolithophorid productivity may be useful in reconstructing past variations in the rain ratio of organic to carbonate carbon, an important control on deep ocean pH and partitioning of CO2 between the atmosphere and ocean. In addition, coccolith Sr/Ca might provide an independent record of past changes in coccolithophorid growth rates, which in combination with data on the carbon isotopic fractionation in coccolithophorid organic matter may permit more reliable calculations of past dissolved CO2 in the surface ocean.
136 citations
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University of Barcelona1, Radboud University Nijmegen2, Pompeu Fabra University3, Babraham Institute4, Barcelona Supercomputing Center5, Catalan Institution for Research and Advanced Studies6, European Bioinformatics Institute7, University of Navarra8, Florida State University9, Max Planck Society10, University of Ulm11, University of Oviedo12
TL;DR: This study provides an integrative portrait of the CLL epigenome, identifies extensive networks of altered regulatory elements and sheds light on the relationship between the genetic and epigenetic architecture of the disease.
Abstract: Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which underlying epigenetic alterations are only partially understood. Here, we analyze the reference epigenome of seven primary CLLs and the regulatory chromatin landscape of 107 primary cases in the context of normal B cell differentiation. We identify that the CLL chromatin landscape is largely influenced by distinct dynamics during normal B cell maturation. Beyond this, we define extensive catalogues of regulatory elements de novo reprogrammed in CLL as a whole and in its major clinico-biological subtypes classified by IGHV somatic hypermutation levels. We uncover that IGHV-unmutated CLLs harbor more active and open chromatin than IGHV-mutated cases. Furthermore, we show that de novo active regions in CLL are enriched for NFAT, FOX and TCF/LEF transcription factor family binding sites. Although most genetic alterations are not associated with consistent epigenetic profiles, CLLs with MYD88 mutations and trisomy 12 show distinct chromatin configurations. Furthermore, we observe that non-coding mutations in IGHV-mutated CLLs are enriched in H3K27ac-associated regulatory elements outside accessible chromatin. Overall, this study provides an integrative portrait of the CLL epigenome, identifies extensive networks of altered regulatory elements and sheds light on the relationship between the genetic and epigenetic architecture of the disease.
135 citations
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TL;DR: In this article, the authors analyse the factors behind the change in aggregate energy consumption in the EU-27, also identifying differences between member states by using the logarithmic-mean divisia index method (LMDI).
135 citations
Authors
Showing all 13643 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Carlo Rovelli | 146 | 1502 | 103550 |
J. González-Nuevo | 144 | 500 | 108318 |
German Martinez | 141 | 1476 | 107887 |
Roland Horisberger | 139 | 1471 | 100458 |
Francisco Herrera | 139 | 1001 | 82976 |
Javier Cuevas | 138 | 1689 | 103604 |
Teresa Rodrigo | 138 | 1831 | 103601 |
L. Toffolatti | 136 | 376 | 95529 |
Elias Campo | 135 | 761 | 85160 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Francisco Matorras | 134 | 1428 | 94627 |
Joe Incandela | 134 | 1549 | 93750 |
Nikhil C. Munshi | 134 | 906 | 67349 |
Luca Scodellaro | 134 | 1741 | 98331 |