scispace - formally typeset
Search or ask a question
Institution

University of Oviedo

EducationOviedo, Spain
About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.


Papers
More filters
Journal ArticleDOI
TL;DR: It is found that fibroblasts and cancer cells express an indistinguishable pericellular collagenolytic activity that allows them to traverse the ECM and that MT1-MMP serves as the major cell-associated proteinase necessary to confer normal or neoplastic cells with invasive activity.
Abstract: As cancer cells traverse collagen-rich extracellular matrix (ECM) barriers and intravasate, they adopt a fibroblast-like phenotype and engage undefined proteolytic cascades that mediate invasive activity. Herein, we find that fibroblasts and cancer cells express an indistinguishable pericellular collagenolytic activity that allows them to traverse the ECM. Using fibroblasts isolated from gene-targeted mice, a matrix metalloproteinase (MMP)–dependent activity is identified that drives invasion independently of plasminogen, the gelatinase A/TIMP-2 axis, gelatinase B, collagenase-3, collagenase-2, or stromelysin-1. In contrast, deleting or suppressing expression of the membrane-tethered MMP, MT1-MMP, in fibroblasts or tumor cells results in a loss of collagenolytic and invasive activity in vitro or in vivo. Thus, MT1-MMP serves as the major cell-associated proteinase necessary to confer normal or neoplastic cells with invasive activity.

585 citations

Journal ArticleDOI
TL;DR: The QTAM scheme is intimately linked with the atomistic picture of the chemical bond, not only allowing the separation of different two-body contributions to the interaction between a pair of atoms but also including an effective many-body contribution to the binding due to the deformation of the atoms within the many-electron system as compared to the free atoms.
Abstract: We make use of the Quantum Theory of Atoms in Molecules (QTAM) to partition the total energy of a many-electron system into intra- and interatomic terms, by explicitly computing both the one- and two-electron contributions. While the general scheme is formally equivalent to that by Bader et al., we focus on the separation and computation of the atomic self-energies and all the interaction terms. The partition is ultimately performed within the density matrices, in analogy with McWeeny's Theory of Electronic Separability, and then carried onto the energy. It is intimately linked with the atomistic picture of the chemical bond, not only allowing the separation of different two-body contributions (point-charge-like, multipolar, total Coulomb, exchange, correlation, ...) to the interaction between a pair of atoms but also including an effective many-body contribution to the binding (self-energy, formally one-body) due to the deformation of the atoms within the many-electron system as compared to the free atoms. Many qualitative ideas about the chemical bond can be quantified using this scheme.

584 citations

Journal ArticleDOI
TL;DR: This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenol structure recognition by specific enzymes produced by intestinal microbial taxa.
Abstract: Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become bioactive at human body, these polyphenols must undergo diverse intestinal transformations, due to the action of digestive enzymes, but also by the action of microbiota metabolism. After elimination of sugar tailoring (generating the corresponding aglycons) and diverse hydroxyl moieties, as well as further backbone reorganizations, the final absorbed compounds enter the portal vein circulation towards liver (where other enzymatic transformations take place) and from there to other organs, including behind the digestive tract or via blood towards urine excretion. During this transit along diverse tissues and organs, they are able to carry out strong antiviral, antibacterial, and antiparasitic activities. This paper revises and discusses these antimicrobial activities of dietary polyphenols and their relevance for human health, shedding light on the importance of polyphenols structure recognition by specific enzymes produced by intestinal microbial taxa.

577 citations

Journal ArticleDOI
TL;DR: Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research and creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and theDevelopment of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.
Abstract: Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.

575 citations

Journal ArticleDOI
TL;DR: Across a range of countries in Europe, using the Young Diagnostic Questionnaire for Internet Addiction yields a prevalence of 'pathological internet use' of 4.4% among adolescents, but varies by country and gender; adolescents lacking emotional and psychological support are at highest risk.
Abstract: Aims To investigate the prevalence of pathological internet use (PIU) and maladaptive internet use (MIU) among adolescents in 11 European countries in relation to demographic, social factors and internet accessibility. Design Cross-sectional survey. Setting The 7th Framework European Union (EU) funded project, Saving and Empowering Young Lives in Europe (SEYLE), is a randomized controlled trial (RCT) evaluating interventions for risk behavioursamongadolescentsinAustria,Estonia,France,Germany,Hungary,Ireland,Israel,Italy,Romania,Slovenia andSpain,withSwedenservingasthecoordinatingcentre.Participants Atotalof 11 956adolescents(female/male: 6731/5225; mean age: 14.9 0.89) recruited from randomly selected schools within the 11 study sites. Measurements Internet users were classified by gender into three categories: adaptive, maladaptive and pathologi- cal, based on their score in the Young Diagnostic Questionnaire for Internet Addiction (YDQ). Findings The overall prevalence of PIU was 4.4%; it was higher among males than females (5.2% versus 3.8%) and differed between countries (c 2 = 309.98; d.f. = 20; P < 0.001). PIU correlated significantly with mean hours online and male gender. Thehighest-rankedonlineactivitieswerewatchingvideos,frequentingchatroomsandsocialnetworking;significantly higherratesof playingsingle-usergameswerefoundinmalesandsocialnetworkinginfemales.Livinginmetropolitan areas was associated with PIU. Students not living with a biological parent, low parental involvement and parental unemployment showed the highest relative risks of both MIU and PIU. Conclusions Across a range of countries in Europe, using the Young Diagnostic Questionnaire for Internet Addiction yields a prevalence of 'pathological internet use' of 4.4% among adolescents, but varies by country and gender; adolescents lacking emotional and psychological support are at highest risk.

575 citations


Authors

Showing all 13643 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Carlo Rovelli1461502103550
J. González-Nuevo144500108318
German Martinez1411476107887
Roland Horisberger1391471100458
Francisco Herrera139100182976
Javier Cuevas1381689103604
Teresa Rodrigo1381831103601
L. Toffolatti13637695529
Elias Campo13576185160
Gabor Istvan Veres135134996104
Francisco Matorras134142894627
Joe Incandela134154993750
Nikhil C. Munshi13490667349
Luca Scodellaro134174198331
Network Information
Related Institutions (5)
Complutense University of Madrid
90.2K papers, 2.1M citations

96% related

University of Valencia
65.6K papers, 1.7M citations

95% related

University of Barcelona
108.5K papers, 3.7M citations

95% related

Autonomous University of Barcelona
80.5K papers, 2.3M citations

94% related

Autonomous University of Madrid
52.8K papers, 1.6M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202396
2022268
20211,825
20201,913
20191,806
20181,721