University of Oviedo

About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.

Circadian rhythms, oxidative stress, and antioxidative defense mechanisms.

Abstract: Endogenous circadian and exogenously driven daily rhythms of antioxidative enzyme activities and of low molecular weight antioxidants (LMWAs) are described in various phylogenetically distant organisms. Substantial amplitudes are detected in several cases, suggesting the significance of rhythmicity in avoiding excessive oxidative stress. Mammalian and/or avian glutathione peroxidase and, as a consequence, glutathione reductase activities follow the rhythm of melatonin. Another hint for an involvement of melatonin in the control of redox processes is seen in its high-affinity binding to cytosolic quinone reductase 2, previously believed to be a melatonin receptor. Although antioxidative protection by pharmacological doses of melatonin is repeatedly reported, explanations of these findings are still insufficient and their physiological and chronobiological relevance is not yet settled. Recent data indicate a role of melatonin in the avoidance of mitochondrial radical formation, a function which may prevail over direct scavenging. Rhythmic changes in oxidative damage of protein and lipid molecules are also reported. Enhanced oxidative protein modification accompanied by a marked increase in the circadian amplitude of this parameter is detected in the Drosophila mutant rosy, which is deficient in the LMWA urate. Preliminary evidence for the significance of circadian rhythmicity in diminishing oxidative stress comes from clock mutants. In Drosophila, moderately enhanced protein damage is described for the arrhythmic and melatonin null mutant per0, but even more elevated, periodic damage is found in the short-period mutant per(s), synchronized to LD 12:12. Remarkably large increases in oxidative protein damage, along with impairment of tissue integrity and--obviously insufficient--compensatory elevations in protective enzymes are observed in a particularly vulnerable organ, the Harderian gland, of another short-period mutant tau, in the Syrian hamster. Mice deficient in the per2 gene homolog are reported to be cancer-prone, a finding which might also relate to oxidative stress. In the dinoflagellate Lingulodinium polyedrum [Gonyaulax polyedra], various treatments that cause oxidative stress result in strong suppressions of melatonin and its metabolite 5-methoxytryptamine (5-MT) and to secondary effects on overt rhythmicity. The glow maximum, depending on the presence of elevated 5-MT at the end of subjective night, decreases in a dose-dependent manner already under moderate, non-lethal oxidative stress, but is restored by replenishing melatonin. Therefore, a general effect of oxidative stress may consist in declines of easily oxidizable signaling molecules such as melatonin, and this can have consequences on the circadian intraorganismal organization and expression of overt rhythms. Recent findings on a redox-sensitive input into the core oscillator via modulation of NPAS2/BMAL1 or CLK/BMAL1 heterodimer binding to DNA indicate a direct influence of cellular redox balance, including oxidative stress, on the circadian clock.

The Determinants of Football Match Attendance Revisited: Empirical Evidence From the Spanish Football League

Abstract: An attendance equation is estimated using data on individual games played in the Spanish First Division Football League. The specification includes as explanatory factors: economic variables, quality, uncertainty and opportunity costs. The authors concentrate the analysis on some specification issues such as controlling the effect of unobservables given the panel data structure of the data set, the type of functional form, and the potential endogeneity of prices. The authors obtain the expected effects on attendance for all the variables. The estimated price elasticities are, in general, smaller than one in absolute value but are sensitive to the specification issues, in particular, the endogeneity of prices.

Planck 2013 results. XXV. Searches for cosmic strings and other topological defects

Abstract: Planck data have been used to provide stringent new constraints on cosmic strings and other defects. We describe forecasts of the CMB power spectrum induced by cosmic strings, calculating these from network models and simulations using line-of-sight Boltzmann solvers. We have studied Nambu-Goto cosmic strings, as well as field theory strings for which radiative effects are important, thus spanning the range of theoretical uncertainty in strings models. We have added the angular power spectrum from strings to that for a simple adiabatic model, with the extra fraction defined as $f_{10}$ at multipole $\ell=10$. This parameter has been added to the standard six parameter fit using COSMOMC with flat priors. For the Nambu-Goto string model, we have obtained a constraint on the string tension of $G\mu/c^2 < 1.5 x 10^{-7}$ and $f_{10} < 0.015$ at 95% confidence that can be improved to $G\mu/c^2 < 1.3 x 10^{-7}$ and $f_{10} < 0.010$ on inclusion of high-$\ell$ CMB data. For the abelian-Higgs field theory model we find, $G\mu_{AH}/c^2 < 3.2 x 10^{-7}$ and $f_{10} < 0.028$. The marginalized likelihoods for $f_{10}$ and in the $f_{10}$--$\Omega_b h^2$ plane are also presented. We have also obtained constraints on $f_{10}$ for models with semi-local strings and global textures for which $G\mu/c^2 < 1.1 x 10^{-6}$. We have made complementarity searches for the specific non-Gaussian signatures of cosmic strings, calibrating with all-sky Planck resolution CMB maps generated from networks of post-recombination strings. We have obtained upper limits on the string tension at 95% confidence of $G\mu/c^2 < 8.8 x 10^{-7}$ using modal bispectrum estimation and $G\mu/c^2 < 7.8 x 10^{-7}$ for real space searches with Minkowski functionals. These are conservative upper bounds because only post-recombination string contributions have been included in the non-Gaussian analysis.

Electrochemical sensors based on molecularly imprinted polymers

Abstract: Molecularly imprinted polymers (MIPs) are becoming an important class of synthetic materials mimicking molecular recognition by natural receptors. This review examines the literature on non-covalent MIP-based electrochemical sensors over the last 10 years. With insight into the different sensing phases, electrochemical transductions and integration strategies, we evaluate achievements and difficulties to date and assess future prospects.