University of Palermo

About: University of Palermo is a education organization based out in Palermo, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 15621 authors who have published 40250 publications receiving 964384 citations. The organization is also known as: Università degli Studi di Palermo & Universita degli Studi di Palermo.

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Abstract: Background and purpose Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS). Methods As a proof of principle, using a double-blind placebo controlled design, 34 ALS patients under treatment with riluzole who were randomized to placebo or TUDCA (1 g twice daily for 54 weeks) were evaluated after a lead-in period of 3 months. The patients were examined every 6 weeks. The primary outcome was the proportion of responders [those subjects with improvement of at least 15% in the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R) slope during the treatment period compared to the lead-in phase]. Secondary outcomes included between-treatment comparison of ALSFRS-R at study end, comparison of the linear regression slopes for ALSFFRS-R mean scores and the occurrence of adverse events. Results Tauroursodeoxycholic acid was well tolerated; there were no between-group differences for adverse events. The proportion of responders was higher under TUDCA (87%) than under placebo (P = 0.021; 43%). At study end baseline-adjusted ALSFRS-R was significantly higher (P = 0.007) in TUDCA than in placebo groups. Comparison of the slopes of regression analysis showed slower progression in the TUDCA than in the placebo group (P Conclusions This pilot study provides preliminary clinical data indicating that TUDCA is safe and may be effective in ALS.

Refinements on IEEE 802.11 Distributed Coordination Function Modeling Approaches

Abstract: With the popularity of the IEEE 802.11 standards, many analytical saturation throughput studies for the distributed coordination function (DCF) have been reported. In this paper, we outline a number of issues and criticalities raised by previously proposed models. In particular, a careful look at backoff counter decrement rules allows us to conclude that, under saturation conditions, the slot immediately following a successful transmission can be accessed only by the station (STA) that has successfully transmitted in the previous channel access. Moreover, due to the specific acknowledgment (ACK) timeout setting adopted in the standard, the slot immediately following a collision cannot be accessed by any STA. Thus, the hypothesis of uncorrelation between consecutive channel slots and statistical homogeneity is not generally true. We propose a new backoff decrement model that retains the simplicity of traditional DCF models while being able to take into account such a correlation, and we compare the accuracy of our model with that of previously proposed approaches.

Gametic embryogenesis and haploid technology as valuable support to plant breeding

Abstract: Plant breeding is focused on continuously increasing crop production to meet the needs of an ever-growing world population, improving food quality to ensure a long and healthy life and address the problems of global warming and environment pollution, together with the challenges of developing novel sources of biofuels. The breeders' search for novel genetic combinations, with which to select plants with improved traits to satisfy both farmers and consumers, is endless. About half of the dramatic increase in crop yield obtained in the second half of the last century has been achieved thanks to the results of genetic improvement, while the residual advance has been due to the enhanced management techniques (pest and disease control, fertilization, and irrigation). Biotechnologies provide powerful tools for plant breeding, and among these ones, tissue culture, particularly haploid and doubled haploid technology, can effectively help to select superior plants. In fact, haploids (Hs), which are plants with gametophytic chromosome number, and doubled haploids (DHs), which are haploids that have undergone chromosome duplication, represent a particularly attractive biotechnological method to accelerate plant breeding. Currently, haploid technology, making possible through gametic embryogenesis the single-step development of complete homozygous lines from heterozygous parents, has already had a huge impact on agricultural systems of many agronomically important crops, representing an integral part in their improvement programmes. The aim of this review was to provide some background, recent advances, and future prospective on the employment of haploid technology through gametic embryogenesis as a powerful tool to support plant breeding.

Fault Lines, how hidden fractures still threaten the World Economy

Abstract: ?Por que sucede la crisis economica de 2008? ?fue provocada por los Estados Unidos como una estrategia expansionista o una simple falla del sistema capitalista? En perspectiva, el mundo de las relaciones productivas impacta sobre el social y viceversa. No es extrano observar el interes de las ciencias sociales por el estudio del riesgo en los ultimos anos. Para los especialistas, el riesgo se corresponde con la probabilidad de sufrir algun dano a futuro...