University of Palermo

About: University of Palermo is a education organization based out in Palermo, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 15621 authors who have published 40250 publications receiving 964384 citations. The organization is also known as: Università degli Studi di Palermo & Universita degli Studi di Palermo.

Effect of boat noise on the behaviour of bluefin tuna Thunnus thynnus in the Mediterranean Sea

Abstract: The effect of boat noise on the behaviour of bluefin tuna Thunnus thynnus was investi- gated in the Egadi Islands, Sicily, during spring 2005 using a fixed tuna trap set near shipping routes. Tuna behaviour was observed when exposed to both natural ambient sound and sound generated by hydrofoil passenger ferries, small boats and large car ferries. Acoustical and behavioural analyses were conducted with and without extraneous sound to define a list of behavioural categories. Each vessel produced different engine sounds with regard to their composition and bandwidth, and all were distinctly different from ambient sound levels. In the absence of boat noise, tuna assumed a con- centrated coordinated school structure with unidirectional swimming and without a precise shape. When a car ferry approached, tuna changed swimming direction and increased their vertical move- ment toward surface or bottom; the school exhibited an unconcentrated structure and uncoordinated swimming behaviour. Hydrofoils appeared to elicit a similar response, but for shorter periods. Ago- nistic behaviour was more evident when exposed to sounds from outboard motors of small boats. This study showed that local noise pollution generated by boats produced behavioural deviations in tuna schools. Schooling enhances tuna homing accuracy during their spawning migration, and an alter- ation in schooling behaviour can affect the accuracy of their migration to spawning and feeding grounds.

RNA recognition by human TLR8 can lead to autoimmune inflammation

Abstract: Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed severe inflammation targeting the pancreas, salivary glands, and joints; and the severity of the specific phenotypes closely correlated with the huTLR8 expression levels. Mice with relatively low expression levels survived and bred successfully but had increased susceptibility to collagen-induced arthritis, and the levels of huTLR8 correlated with proinflammatory cytokines in the joints of the animals. At the cellular level, huTLR8 signaling exerted a DC-intrinsic effect leading to up-regulation of co-stimulatory molecules and subsequent T cell activation. A pathogenic role for TLR8 in human diseases was suggested by its increased expression in patients with systemic arthritis and the correlation of TLR8 expression with the elevation of IL-1β levels and disease status. We found that the consequence of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from those related to TLR7 signaling, and points to specific inflammatory diseases that may benefit from inhibition of TLR8 in humans.

Measurements and Observations in the XXI century (MOXXI): innovation and multi-disciplinarity to sense the hydrological cycle

Abstract: To promote the advancement of novel observation techniques that may lead to new sources of information to help better understand the hydrological cycle, the International Association of Hydrological Sciences (IAHS) established the Measurements and Observations in the XXI century (MOXXI) Working Group in July 2013 The group comprises a growing community of tech-enthusiastic hydrologists that design and develop their own sensing systems, adopt a multi-disciplinary perspective in tackling complex observations, often use low-cost equipment intended for other applications to build innovative sensors, or perform opportunistic measurements This paper states the objectives of the group and reviews major advances carried out by MOXXI members toward the advancement of hydrological sciences Challenges and opportunities are outlined to provide strategic guidance for advancement of measurement, and thus discovery