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Institution

University of Palermo

EducationPalermo, Italy
About: University of Palermo is a education organization based out in Palermo, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 15621 authors who have published 40250 publications receiving 964384 citations. The organization is also known as: Università degli Studi di Palermo & Universita degli Studi di Palermo.


Papers
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Journal ArticleDOI
TL;DR: This study represents a first preliminary curated meta-analysis of apple transcriptomic responses to biotic stresses and discovered the presence of several proteins affected by more than one biotic stress including a WRKY40 and some highly interactive proteins such as heat shock proteins.
Abstract: Identifying key information in transcriptomic data is very important, especially when the “omic” study deals with plant responses to stresses in field conditions where a high number of variables and disturbing factors may affect the analysis. In this meta-analysis we collected 12 transcriptomic works in Malus in order to identify which key genes, proteins, gene categories are involved in general plant pathological conditions and those features linked with exclusive biotic stress responses. Those genes that are only related with molecular responses to pathogen attacks and those linked with other plant physiological processes were identified. A pipeline composed by pathway and gene set enrichment analysis, protein-protein interaction networks and gene visualization tools was employed. A total of 13,230 genes of the 12 studies were analyzed with functional data mining tools: 5,215 were upregulated, 8,015 were downregulated. Gene set enrichment analysis pointed out that photosynthesis was inhibited by Erwinia amylovora and fungal pathogens. Different hormonal crosstalk was linked with responses to different pathogens. Gibberellin-related pathways, ABA-related were mostly repressed by fungal pathogens. Relating to transcription factors, genes encoding MYBs and WRKY2 were downregulated by fungal pathogens and 12 WRKYs were commonly regulated by different biotic stresses The protein-protein interaction analysis discovered the presence of several proteins affected by more than one biotic stress including a WRKY40 and some highly interactive proteins such as heat shock proteins. This study represents a first preliminary curated meta-analysis of apple transcriptomic responses to biotic stresses.

428 citations

Journal ArticleDOI
TL;DR: A growing body of studies suggest that intracellular Mg may play a key role in modulating insulin-mediated glucose uptake and vascular tone, and it is suggested that a reduced intrace cellular Mg concentration might be the missing link helping to explain the epidemiological association between NIDDM and hypertension.

427 citations

Journal ArticleDOI
TL;DR: The major advances and current trends on Non Celiac Gluten sensitivity are reported, including an overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria.
Abstract: Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a “re-discovered” disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.

424 citations

Journal ArticleDOI
TL;DR: The role of smoking as an independent predictor of clinical, surgical, and endoscopic recurrence in Crohn's disease is evaluated.

422 citations

Journal ArticleDOI
TL;DR: A simple procedure is proposed to improve the computation of the pressure distribution in the dynamics of liquids, based on the use of a density diffusion term in the equation for the mass conservation.

421 citations


Authors

Showing all 15895 results

NameH-indexPapersCitations
Robin M. Murray1711539116362
Frede Blaabjerg1472161112017
Jean Bousquet145128896769
Zhanhu Guo12888653378
Jean Ballet11526346301
Antonio Facchetti11160251885
Michele Pagano9730642211
Frank Z. Stanczyk9362030244
Eleonora Troja9127130873
Francesco Sciortino9053628956
Zev Rosenwaks8977232039
Antonio Russo8893434563
Carlo Salvarani8873031699
Giuseppe Basso8764333320
Antonio Craxì8665939463
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023147
2022384
20212,977
20202,753
20192,412
20182,250