Institution
University of Palermo
Education•Palermo, Italy•
About: University of Palermo is a education organization based out in Palermo, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 15621 authors who have published 40250 publications receiving 964384 citations. The organization is also known as: Università degli Studi di Palermo & Universita degli Studi di Palermo.
Topics: Population, Cancer, Catalysis, Diabetes mellitus, Volcano
Papers published on a yearly basis
Papers
More filters
TL;DR: A hierarchical arrangement of stocks traded in a financial market is found by investigating the daily time series of the logarithm of stock price and the hierarchical tree of the subdominant ultrametric space associated with the graph provides a meaningful economic taxonomy.
Abstract: I find a hierarchical arrangement of stocks traded in a financial market by investigating the daily time series of the logarithm of stock price. The topological space is a subdominant ultrametric space associated with a graph connecting the stocks of the portfolio analyzed. The graph is obtained starting from the matrix of correlation coefficient computed between all pairs of stocks of the portfolio by considering the synchronous time evolution of the difference of the logarithm of daily stock price. The hierarchical tree of the subdominant ultrametric space associated with the graph provides a meaningful economic taxonomy.
1,808 citations
TL;DR: It is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism, ovarian dysfunction, and/or polycystic ovaries, and the exclusion of related disorders.
1,678 citations
TL;DR: It is proposed that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity.
Abstract: Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored this heterogeneity with a Wnt reporter construct and observed that high Wnt activity functionally designates the colon cancer stem cell (CSC) population. In adenocarcinomas, high activity of the Wnt pathway is observed preferentially in tumour cells located close to stromal myofibroblasts, indicating that Wnt activity and cancer stemness may be regulated by extrinsic cues. In agreement with this notion, myofibroblast-secreted factors, specifically hepatocyte growth factor, activate beta-catenin-dependent transcription and subsequently CSC clonogenicity. More significantly, myofibroblast-secreted factors also restore the CSC phenotype in more differentiated tumour cells both in vitro and in vivo. We therefore propose that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity.
1,674 citations
TL;DR: This paper deals with fitting piecewise terms in regression models where one or more break-points are true parameters of the model and a simple linearization technique is called for, taking advantage of the linear formulation of the problem.
Abstract: This paper deals with fitting piecewise terms in regression models where one or more break-points are true parameters of the model For estimation, a simple linearization technique is called for, taking advantage of the linear formulation of the problem As a result, the method is suitable for any regression model with linear predictor and so current software can be used; threshold modelling as function of explanatory variables is also allowed Differences between the other procedures available are shown and relative merits discussed Simulations and two examples are presented to illustrate the method
1,607 citations
Utrecht University1, University of Alabama at Birmingham2, Pennsylvania State University3, Columbia University4, University of Palermo5, University of California, San Diego6, Hacettepe University7, Erasmus University Medical Center8, Cardiff University9, University of Siena10, University of Colombo11, University of Adelaide12, Northwestern University13, Imperial College London14, University of Oklahoma15, University of California, Los Angeles16, University of Pennsylvania17
TL;DR: Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk.
1,585 citations
Authors
Showing all 15895 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Robin M. Murray | 171 | 1539 | 116362 |
| Frede Blaabjerg | 147 | 2161 | 112017 |
| Jean Bousquet | 145 | 1288 | 96769 |
| Zhanhu Guo | 128 | 886 | 53378 |
| Jean Ballet | 115 | 263 | 46301 |
| Antonio Facchetti | 111 | 602 | 51885 |
| Michele Pagano | 97 | 306 | 42211 |
| Frank Z. Stanczyk | 93 | 620 | 30244 |
| Eleonora Troja | 91 | 271 | 30873 |
| Francesco Sciortino | 90 | 536 | 28956 |
| Zev Rosenwaks | 89 | 772 | 32039 |
| Antonio Russo | 88 | 934 | 34563 |
| Carlo Salvarani | 88 | 730 | 31699 |
| Giuseppe Basso | 87 | 643 | 33320 |
| Antonio Craxì | 86 | 659 | 39463 |