University of Paris

About: University of Paris is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Medicine. The organization has 102426 authors who have published 174180 publications receiving 5041753 citations. The organization is also known as: Sorbonne.

Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events

Abstract: Background The intensity of antiplatelet therapy during percutaneous coronary intervention (PCI) is an important determinant of PCI-related ischemic complications. Cangrelor is a potent intravenous adenosine diphosphate (ADP)–receptor antagonist that acts rapidly and has quickly reversible effects. Methods In a double-blind, placebo-controlled trial, we randomly assigned 11,145 patients who were undergoing either urgent or elective PCI and were receiving guideline-recommended therapy to receive a bolus and infusion of cangrelor or to receive a loading dose of 600 mg or 300 mg of clopidogrel. The primary efficacy end point was a composite of death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis at 48 hours after randomization; the key secondary end point was stent thrombosis at 48 hours. The primary safety end point was severe bleeding at 48 hours. Results The rate of the primary efficacy end point was 4.7% in the cangrelor group and 5.9% in the clopidogrel group (adjusted od...

The INTERSPEECH 2013 computational paralinguistics challenge: social signals, conflict, emotion, autism

Abstract: The INTERSPEECH 2013 Computational Paralinguistics Challenge provides for the first time a unified test-bed for Social Signals such as laughter in speech. It further introduces conflict in group discussions as a new task and deals with autism and its manifestations in speech. Finally, emotion is revisited as task, albeit with a broader range of overall twelve enacted emotional states. In this paper, we describe these four Sub-Challenges, their conditions, baselines, and a new feature set by the openSMILE toolkit, provided to the participants. Index Terms: Computational Paralinguistics, Challenge, Social Signals, Conflict, Emotion, Autism

MUlti-Store Tracker (MUSTer): A cognitive psychology inspired approach to object tracking

Abstract: Variations in the appearance of a tracked object, such as changes in geometry/photometry, camera viewpoint, illumination, or partial occlusion, pose a major challenge to object tracking. Here, we adopt cognitive psychology principles to design a flexible representation that can adapt to changes in object appearance during tracking. Inspired by the well-known Atkinson-Shiffrin Memory Model, we propose MUlti-Store Tracker (MUSTer), a dual-component approach consisting of short- and long-term memory stores to process target appearance memories. A powerful and efficient Integrated Correlation Filter (ICF) is employed in the short-term store for short-term tracking. The integrated long-term component, which is based on keypoint matching-tracking and RANSAC estimation, can interact with the long-term memory and provide additional information for output control. MUSTer was extensively evaluated on the CVPR2013 Online Object Tracking Benchmark (OOTB) and ALOV++ datasets. The experimental results demonstrated the superior performance of MUSTer in comparison with other state-of-art trackers.

Herpes simplex virus encephalitis in human UNC-93B deficiency.

Abstract: Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral encephalitis in western countries. Its pathogenesis remains unclear, as it affects otherwise healthy patients and only a small minority of HSV-1-infected individuals. Here, we elucidate a genetic etiology for HSE in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-alpha/beta and -lambda antiviral responses. HSE can result from a single-gene immunodeficiency that does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Other severe infectious diseases may also reflect monogenic disorders of immunity.