University of Paris

About: University of Paris is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 102426 authors who have published 174180 publications receiving 5041753 citations. The organization is also known as: Sorbonne.

Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

Abstract: BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability). RESULTS The study was stopped early because of futility after 656 participants had undergone randomization (434 patients to endovascular therapy and 222 to intravenous t-PA alone). The proportion of participants with a modified Rankin score of 2 or less at 90 days did not differ significantly according to treatment (40.8% with endovascular therapy and 38.7% with intravenous t-PA; absolute adjusted difference, 1.5 percentage points; 95% confidence interval [CI], −6.1 to 9.1, with adjustment for the National Institutes of Health Stroke Scale [NIHSS] score [8–19, indicating moderately severe stroke, or ≥20, indicating severe stroke]), nor were there significant differences for the predefined subgroups of patients with an NIHSS score of 20 or higher (6.8 percentage points; 95% CI, −4.4 to 18.1) and those with a score of 19 or lower (−1.0 percentage point; 95% CI, −10.8 to 8.8). Findings in the endovascular-therapy and intravenous t-PA groups were similar for mortality at 90 days (19.1% and 21.6%, respectively; P = 0.52) and the proportion of patients with symptomatic intracerebral hemorrhage within 30 hours after initiation of t-PA (6.2% and 5.9%, respectively; P = 0.83). CONCLUSIONS The trial showed similar safety outcomes and no significant difference in functional independence with endovascular therapy after intravenous t-PA, as compared with intravenous t-PA alone. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT00359424.)

The reversal of the star formation-density relation in the distant universe

Abstract: Aims We study the relationship between the local environment of galaxies and their star formation rate (SFR) in the Great Observatories Origins Deep Survey, GOODS, at z∼1 Methods We use ultradeep imaging at 24� m with the MIPS camera onboard Spitzer to determine the contribution of obscured light to the SFR of galaxies over the redshift range 08≤ z ≤12 Accurate galaxy densities are measured thanks to the large sample of ∼1200 spectroscopic redshifts with high (∼70 %) spectroscopic completeness Morphology and stellar masses are derived from deep HST-ACS imaging, supplemented by ground based imaging programs and photometry from the IRAC camera onboard Spitzer Results We show that the star formation‐density relation observed locally was reversed at z∼ 1: the average SFR of an individual galaxy increased with local galaxy density when the universe was less than half its present age Hierarchical galaxy for mation models (simulated lightcones from the Millennium model) predicted such a reversal to occur only at earlier epochs (z>2) and at a lower level We present a remarkable structure at z∼ 1016, containing X-ray traced galaxy concentrations, which will eventually merge into a Virgo-like cluster This structure illustrates how the ind ividual SFR of galaxies increases with density and shows that it is the∼1‐2 Mpc scale that affects most the star formation in galaxies at z∼ 1 The SFR of z∼ 1 galaxies is found to correlate with stellar mass suggesting that mass plays a role in the observed star formation‐density trend However the specific SFR ( =SFR/M⋆) decreases with stellar mass while it increases with galaxy density, which i mplies that the environment does directly affect the star formation activity of galaxies Major mergers do not appear to be the unique or even major cause for this effect since nearly half (46 %) of the luminous infrared galaxies (LIRGs) at z∼ 1 present the HST-ACS morphology of spirals, while only a third present a clear signature of major mergers The remaining galaxies are divided into compact (9 %) and irregular (14 %) galaxies Moreover, the specific SFR o f major mergers is only marginally stronger than that of spirals Conclusions These findings constrain the influence of the growth of large- scale structures on the star formation history of galaxies Reproducing the SFR‐density relation at z∼ 1 is a new challenge for models, requiring a correct balance between mass assembly through mergers and in-situ star formation at early epochs

Oxidant and antioxidant signalling in plants: a re-evaluation of the concept of oxidative stress in a physiological context

Abstract: While the chemical nature of reactive oxygen species (ROS) dictates that they are potentially harmful to cells, recent genetic evidence suggests that in planta purely physicochemical damage may be much more limited than previously thought. The most potentially deleterious effect of ROS under most conditions is that at high concentrations they trigger genetically programmed cell suicide events. Moreover, because plants use ROS as second messengers in signal transduction cascades in processes as diverse as mitosis, tropisms and cell death, their accumulation is crucial to plant development as well as defence. Direct ROS signal transduction will ensue only if ROS escape destruction by antioxidants or are otherwise consumed in a ROS cascade. Thus, the major low molecular weight antioxidants determine the specificity of the signal. They are also themselves signal-transducing molecules that can either signal independently or further transmit ROS signals. The moment has come to re-evaluate the concept of oxidative stress. In contrast to this pejorative or negative term, implying a state to be avoided, we propose that the syndrome would be more usefully described as 'oxidative signalling', that is, an important and critical function associated with the mechanisms by which plant cells sense the environment and make appropriate adjustments to gene expression, metabolism and physiology.

Treating rheumatoid arthritis to target: recommendations of an international task force

Abstract: Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA).