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Institution

University of Paris

EducationParis, France
About: University of Paris is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 102426 authors who have published 174180 publications receiving 5041753 citations. The organization is also known as: Sorbonne.


Papers
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Journal ArticleDOI
TL;DR: New findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.
Abstract: Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol-gel transition temperature at body temperature promoting prolonged release of pharmacological agents). Pharmaceutical evaluation consists in determining the rheological behaviour (flow curve or oscillatory studies), sol-gel transition temperature, in vitro drug release using either synthetic or physiological membrane and (bio)adhesion characteristics. Poloxamer 407 formulations led to enhanced solubilisation of poorly water-soluble drugs and prolonged release profile for many galenic applications (e.g., oral, rectal, topical, ophthalmic, nasal and injectable preparations) but did not clearly show any relevant advantages when used alone. Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimising sol-gel transition temperature or increasing bioadhesive properties. Inclusion of liposomes or micro(nano)particles in Poloxamer 407 formulations offers interesting prospects, as well. Besides these promising data, Poloxamer 407 has been held responsible for lipidic profile alteration and possible renal toxicity, which compromises its development for parenteral applications. In addition, new findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.

1,036 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a legal opinion on the applicability of commercial or impression systématiques in the context of the agreement of the publication mathématique de l'I.H.É.S.
Abstract: © Publications mathématiques de l’I.H.É.S., 1999, tous droits réservés. L’accès aux archives de la revue « Publications mathématiques de l’I.H.É.S. » (http:// www.ihes.fr/IHES/Publications/Publications.html) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/legal.php). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.

1,035 citations

Proceedings ArticleDOI
15 Jun 2019
TL;DR: This work proposes two novel, complementary methods using (i) entropy loss and (ii) adversarial loss respectively for unsupervised domain adaptation in semantic segmentation with losses based on the entropy of the pixel-wise predictions.
Abstract: Semantic segmentation is a key problem for many computer vision tasks. While approaches based on convolutional neural networks constantly break new records on different benchmarks, generalizing well to diverse testing environments remains a major challenge. In numerous real-world applications, there is indeed a large gap between data distributions in train and test domains, which results in severe performance loss at run-time. In this work, we address the task of unsupervised domain adaptation in semantic segmentation with losses based on the entropy of the pixel-wise predictions. To this end, we propose two novel, complementary methods using (i) entropy loss and (ii) adversarial loss respectively. We demonstrate state-of-the-art performance in semantic segmentation on two challenging “synthetic-2-real” set-ups and show that the approach can also be used for detection.

1,034 citations

Journal ArticleDOI
01 Feb 1984-Nature
TL;DR: The first major horizon of ice-rafting occurred at about 2.4 Myr, and was preceded by a minor pulse of icerafting at 2.5 Myr as discussed by the authors, and the carbon isotope record shows that the site has been bathed by a water mass of similar characteristics to present-day North Atlantic deep water at least since 3.5
Abstract: We report here that DSDP Site 552A, cored with the hydraulic piston corer on the west flank of Rockall Bank, recovered an undisturbed sequence of alternating white deep-sea carbonate oozes and dark-coloured layers that are rich in glacial debris. Oxygen isotope analysis of the sequence together with detailed nannofossil and palaeomagnetic stratigraphy shows that the first major horizon of ice-rafting occurred at about 2.4 Myr, and was preceded by a minor pulse of ice-rafting at about 2.5 Myr. The carbon isotope record shows that the site has been bathed by a water mass of similar characteristics to present-day North Atlantic deep water at least since 3.5 Myr.

1,027 citations

Journal ArticleDOI
01 Jun 1977-Nature
TL;DR: In this article, a history of geodynamic evolution of the Mediterranean leading to the salinity crisis is outlined, based on the 'desiccated deep-basin model' and an accurate portrayal of the crisis is presented.
Abstract: A history of geodynamic evolution of the Mediterranean leading to the salinity crisis is outlined, based on the ‘desiccated deep-basin model’. An accurate portrayal of the crisis is presented, based on data from new drilling and studies of on-land geology.

1,026 citations


Authors

Showing all 102613 results

NameH-indexPapersCitations
Guido Kroemer2361404246571
David H. Weinberg183700171424
Paul M. Thompson1832271146736
Chris Sander178713233287
Sophie Henrot-Versille171957157040
Richard H. Friend1691182140032
George P. Chrousos1691612120752
Mika Kivimäki1661515141468
Martin Karplus163831138492
William J. Sandborn1621317108564
Darien Wood1602174136596
Monique M.B. Breteler15954693762
Paul Emery1581314121293
Wolfgang Wagner1562342123391
Joao Seixas1531538115070
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202376
2022602
202116,433
202015,008
201911,047
20189,090