University of Paris

About: University of Paris is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Transplantation. The organization has 102426 authors who have published 174180 publications receiving 5041753 citations. The organization is also known as: Sorbonne.

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Abstract: Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

Mechanics of Solid Materials

Abstract: 1. Elements of the physical mechanisms of deformation and fracture 2. Elements of continuum mechanics and thermodynamics 3. Identification and theological classification of real solids 4. Linear elasticity, thermoelasticity and viscoelasticity 5. Plasticity 6. Viscoplasticity 7. Damage mechanics 8. Crack mechanics.

Advanced capabilities for materials modelling with Quantum ESPRESSO.

Abstract: Quantum ESPRESSO is an integrated suite of open-source computer codes for quantum simulations of materials using state-of-the-art electronic-structure techniques, based on density-functional theory, density-functional perturbation theory, and many-body perturbation theory, within the plane-wave pseudopotential and projector-augmented-wave approaches Quantum ESPRESSO owes its popularity to the wide variety of properties and processes it allows to simulate, to its performance on an increasingly broad array of hardware architectures, and to a community of researchers that rely on its capabilities as a core open-source development platform to implement their ideas In this paper we describe recent extensions and improvements, covering new methodologies and property calculators, improved parallelization, code modularization, and extended interoperability both within the distribution and with external software

Guidelines on the management of valvular heart disease (version 2012)

Abstract: ACE : angiotensin-converting enzyme AF : atrial fibrillation aPTT : activated partial thromboplastin time AR : aortic regurgitation ARB : angiotensin receptor blockers AS : aortic stenosis AVR : aortic valve replacement BNP : B-type natriuretic peptide BSA : body surface area CABG : coronary artery bypass grafting CAD : coronary artery disease CMR : cardiac magnetic resonance CPG : Committee for Practice Guidelines CRT : cardiac resynchronization therapy CT : computed tomography EACTS : European Association for Cardio-Thoracic Surgery ECG : electrocardiogram EF : ejection fraction EROA : effective regurgitant orifice area ESC : European Society of Cardiology EVEREST : (Endovascular Valve Edge-to-Edge REpair STudy) HF : heart failure INR : international normalized ratio LA : left atrial LMWH : low molecular weight heparin LV : left ventricular LVEF : left ventricular ejection fraction LVEDD : left ventricular end-diastolic diameter LVESD : left ventricular end-systolic diameter MR : mitral regurgitation MS : mitral stenosis MSCT : multi-slice computed tomography NYHA : New York Heart Association PISA : proximal isovelocity surface area PMC : percutaneous mitral commissurotomy PVL : paravalvular leak RV : right ventricular rtPA : recombinant tissue plasminogen activator SVD : structural valve deterioration STS : Society of Thoracic Surgeons TAPSE : tricuspid annular plane systolic excursion TAVI : transcatheter aortic valve implantation TOE : transoesophageal echocardiography TR : tricuspid regurgitation TS : tricuspid stenosis TTE : transthoracic echocardiography UFH : unfractionated heparin VHD : valvular heart disease 3DE : three-dimensional echocardiography Guidelines summarize and evaluate all evidence available, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well …

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Abstract: We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncontrolled exponential clonal proliferation of mature T cells (with gammadelta+ or alphabeta+ T cell receptors) has occurred in the two youngest patients. Both patients' clones showed retrovirus vector integration in proximity to the LMO2 proto-oncogene promoter, leading to aberrant transcription and expression of LMO2. Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.