Institution
University of Paris
Education•Paris, France•
About: University of Paris is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Medicine. The organization has 102426 authors who have published 174180 publications receiving 5041753 citations. The organization is also known as: Sorbonne.
Topics: Population, Medicine, Context (language use), Transplantation, Gene
Papers published on a yearly basis
Papers
More filters
••
Tel Aviv University1, Ludwig Maximilian University of Munich2, Hebrew University of Jerusalem3, Erasmus University Rotterdam4, Sapienza University of Rome5, University of Helsinki6, Semmelweis University7, Boston Children's Hospital8, University of Copenhagen9, University of Toronto10, University of Florence11, Jagiellonian University12, University of Barcelona13, University of Naples Federico II14, University of Paris15, University of Edinburgh16
TL;DR: These revised Porto criteria for the diagnosis of P IBD have been developed to meet present challenges and developments in PIBD and provide up-to-date guidelines for the definition and diagnosis of the IBD spectrum.
Abstract: Background: The diagnosis of pediatric-onset inflammatory bowel disease (PIBD) can be challenging in choosing the most informative diagnostic tests and correctly classifying PIBD into its different subtypes. Recent advances in our understanding of the natural history and phenotype of PIBD, increasing availability of serological and fecal biomarkers, and the emergence of novel endoscopic and imaging technologies taken together have made the previous Porto criteria for the diagnosis of PIBD obsolete. Methods: We aimed to revise the original Porto criteria using an evidencebased approach and consensus process to yield specific practice recommendations for the diagnosis of PIBD. These revised criteria are based on the Paris classification of PIBD and the original Porto criteria while incorporating novel data, such as for serum and fecal biomarkers. A consensus of at least 80% of participants was achieved for all recommendations and the summary algorithm. Results: The revised criteria depart from existing criteria by defining 2 categories of ulcerative colitis (UC, typical and atypical); atypical phenotypes of UC should be treated as UC. A novel approach based on multiple criteria for diagnosing IBD-unclassified (IBD-U) is proposed. Specifically, these revised criteria recommend upper gastrointestinal endoscopy and ileocolonscopy for all suspected patients with PIBD, with small bowel imaging (unless typical UC after endoscopy and histology) by magnetic resonance enterography or wireless capsule endoscopy.
929 citations
••
TL;DR: The Model of Ozone and Related Chemical Tracers (MOZART) as discussed by the authors is based on the NCAR Model of Atmospheric Transport and Chemistry (MATCH) and can easily be driven with various meteorological inputs and model resolutions.
Abstract: [1] We have developed a global three-dimensional chemical transport model called Model of Ozone and Related Chemical Tracers (MOZART), version 2. This model, which will be made available to the community, is built on the framework of the National Center for Atmospheric Research (NCAR) Model of Atmospheric Transport and Chemistry (MATCH) and can easily be driven with various meteorological inputs and model resolutions. In this work, we describe the standard configuration of the model, in which the model is driven by meteorological inputs every 3 hours from the middle atmosphere version of the NCAR Community Climate Model (MACCM3) and uses a 20-min time step and a horizontal resolution of 2.8° latitude × 2.8° longitude with 34 vertical levels extending up to approximately 40 km. The model includes a detailed chemistry scheme for tropospheric ozone, nitrogen oxides, and hydrocarbon chemistry, with 63 chemical species. Tracer advection is performed using a flux-form semi-Lagrangian scheme with a pressure fixer. Subgrid-scale convective and boundary layer parameterizations are included in the model. Surface emissions include sources from fossil fuel combustion, biofuel and biomass burning, biogenic and soil emissions, and oceanic emissions. Parameterizations of dry and wet deposition are included. Stratospheric concentrations of several long-lived species (including ozone) are constrained by relaxation toward climatological values. The distribution of tropospheric ozone is well simulated in the model, including seasonality and horizontal and vertical gradients. However, the model tends to overestimate ozone near the tropopause at high northern latitudes. Concentrations of nitrogen oxides (NOx) and nitric acid (HNO3) agree well with observed values, but peroxyacetylnitrate (PAN) is overestimated by the model in the upper troposphere at several locations. Carbon monoxide (CO) is simulated well at most locations, but the seasonal cycle is underestimated at some sites in the Northern Hemisphere. We find that in situ photochemical production and loss dominate the tropospheric ozone budget, over input from the stratosphere and dry deposition. Approximately 75% of the tropospheric production and loss of ozone occurs within the tropics, with large net production in the tropical upper troposphere. Tropospheric production and loss of ozone are three to four times greater in the northern extratropics than the southern extratropics. The global sources of CO consist of photochemical production (55%) and direct emissions (45%). The tropics dominate the chemistry of CO, accounting for about 75% of the tropospheric production and loss. The global budgets of tropospheric ozone and CO are generally consistent with the range found in recent studies. The lifetime of methane (9.5 years) and methylchloroform (5.7 years) versus oxidation by tropospheric hydroxyl radical (OH), two useful measures of the global abundance of OH, agree well with recent estimates. Concentrations of nonmethane hydrocarbons and oxygenated intermediates (carbonyls and peroxides) generally agree well with observations.
928 citations
••
TL;DR: In this paper, the authors investigated the potential and approaches for using optical remote sensing to assess vegetation water content at the leaf level using laboratory measurements, the radiative transfer model PROSPECT and a sensitivity analysis.
928 citations
••
University of the Basque Country1, Carlos III Health Institute2, Ikerbasque3, University of Salamanca4, National Health Service5, University of Manchester6, Imperial College London7, Mayo Clinic8, Sapienza University of Rome9, University of Copenhagen10, University of Glasgow11, University of Regensburg12, Yale University13, University of Padua14, University of Edinburgh15, University of Minnesota16, Marche Polytechnic University17, University of Rennes18, University of Paris19, University of Florence20, University of Milano-Bicocca21, University of Zurich22, Erasmus University Rotterdam23, University of Barcelona24
TL;DR: This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.
Abstract: Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlighted
926 citations
••
TL;DR: The Large Synoptic Survey Telescope (LSST) as discussed by the authors is a large, wide-field ground-based system designed to obtain repeated images covering the sky visible from Cerro Pachon in northern Chile.
Abstract: We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the solar system, exploring the transient optical sky, and mapping the Milky Way. LSST will be a large, wide-field ground-based system designed to obtain repeated images covering the sky visible from Cerro Pachon in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg2 field of view, a 3.2-gigapixel camera, and six filters (ugrizy) covering the wavelength range 320–1050 nm. The project is in the construction phase and will begin regular survey operations by 2022. About 90% of the observing time will be devoted to a deep-wide-fast survey mode that will uniformly observe a 18,000 deg2 region about 800 times (summed over all six bands) during the anticipated 10 yr of operations and will yield a co-added map to r ~ 27.5. These data will result in databases including about 32 trillion observations of 20 billion galaxies and a similar number of stars, and they will serve the majority of the primary science programs. The remaining 10% of the observing time will be allocated to special projects such as Very Deep and Very Fast time domain surveys, whose details are currently under discussion. We illustrate how the LSST science drivers led to these choices of system parameters, and we describe the expected data products and their characteristics.
921 citations
Authors
Showing all 102613 results
Name | H-index | Papers | Citations |
---|---|---|---|
Guido Kroemer | 236 | 1404 | 246571 |
David H. Weinberg | 183 | 700 | 171424 |
Paul M. Thompson | 183 | 2271 | 146736 |
Chris Sander | 178 | 713 | 233287 |
Sophie Henrot-Versille | 171 | 957 | 157040 |
Richard H. Friend | 169 | 1182 | 140032 |
George P. Chrousos | 169 | 1612 | 120752 |
Mika Kivimäki | 166 | 1515 | 141468 |
Martin Karplus | 163 | 831 | 138492 |
William J. Sandborn | 162 | 1317 | 108564 |
Darien Wood | 160 | 2174 | 136596 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Paul Emery | 158 | 1314 | 121293 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Joao Seixas | 153 | 1538 | 115070 |