Institution
University of Patras
Education•Pátrai, Greece•
About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.
Topics: Population, Catalysis, Finite element method, Nonlinear system, Graphene
Papers published on a yearly basis
Papers
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TL;DR: P1Y substitution enhances affinity of HLA‐A2.1‐associated peptides without altering their antigenic specificity and provides the necessary tool for the identification of cryptic tumor and virus epitopes which could be used for peptide‐based immunotherapy.
Abstract: Low-affinity MHC class I-associated cryptic epitopes derived from self proteins overexpressed in a wide variety of human tumors or derived from antigens of viruses exhibiting a high mutation rate, could be interesting candidates for tumor and virus immunotherapy, respectively. However, identification of low-affinity MHC-associated epitopes comes up against their poor immunogenicity. Here we describe an approach that enhances immunogenicity of nonimmunogenic low-affinity HLA-A2.1-binding peptides. It consists of modifying their sequence by introducing a tyrosine in the first position (P1Y). P1Y substitution enhances affinity of HLA-A2.1-associated peptides without altering their antigenic specificity. In fact, P1Y variants of ten nonimmunogenic low-affinity peptides exhibited a 2.3- to 55-fold higher binding affinity and/or stabilized the HLA-A2.1 for at least 2 h more than the corresponding native peptides. More importantly, P1Y variants efficiently triggered in vivo native peptide-specific CTL which also recognized the corresponding naturally processed epitope. The possibility for generating CTL against any low-affinity HLA-A2.1-associated peptide provides us with the necessary tool for the identification of cryptic tumor and virus epitopes which could be used for peptide-based immunotherapy.
171 citations
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TL;DR: In this paper, the authors consider non-Abelian T-duality on N = 1 supergravity backgrounds possessing well understood field theory duals and show that the central charge and the entanglement entropy are left invariant by this dualisation.
171 citations
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TL;DR: This review introduces metabolic pathways that are involved in EMT, including glycolysis, the TCA cycle, lipid and amino acid metabolism, and describes the relationship between EMT factors and cancer metabolism, to present therapeutic opportunities involving EMT.
Abstract: The epithelial-mesenchymal transition (EMT) represents a biological program during which epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is normally observed during organismal development, wound healing and tissue fibrosis. However, this process can be hijacked by cancer cells and is often associated with resistance to apoptosis, acquisition of tissue invasiveness, cancer stem cell characteristics, and cancer treatment resistance. It is becoming evident that EMT is a complex, multifactorial spectrum, often involving episodic, transient or partial events. Multiple factors have been causally implicated in EMT including transcription factors (e.g., SNAIL, TWIST, ZEB), epigenetic modifications, microRNAs (e.g., miR-200 family) and more recently, long non-coding RNAs. However, the relevance of metabolic pathways in EMT is only recently being recognized. Importantly, alterations in key metabolic pathways affect cancer development and progression. In this review, we report the roles of key EMT factors and describe their interactions and interconnectedness. We introduce metabolic pathways that are involved in EMT, including glycolysis, the TCA cycle, lipid and amino acid metabolism, and characterize the relationship between EMT factors and cancer metabolism. Finally, we present therapeutic opportunities involving EMT, with particular focus on cancer metabolic pathways.
171 citations
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TL;DR: In this article, in situ Raman spectroscopy has been used to study the molecular structure of V 2 O 5 /TiO 2 catalysts with V surface density, n s, in the range 2.5-18.7 VO x /nm 2.
171 citations
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TL;DR: Cerebral CT angiography has an equal sensitivity to DSA in the detection of intracranial aneurysms >3 mm, and the use of digital subtractionAngiography as a diagnostic tool can be limited in equivocal cases.
170 citations
Authors
Showing all 13529 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thomas J. Meyer | 120 | 1078 | 68519 |
Thoralf M. Sundt | 112 | 755 | 55708 |
Chihaya Adachi | 112 | 908 | 61403 |
Eleftherios P. Diamandis | 110 | 1064 | 52654 |
Roland Siegwart | 105 | 1154 | 51473 |
T. Geralis | 99 | 808 | 52221 |
Spyros N. Pandis | 97 | 377 | 51660 |
Michael Tsapatsis | 77 | 375 | 20051 |
George K. Karagiannidis | 76 | 653 | 24066 |
Eleftherios Mylonakis | 75 | 448 | 21413 |
Matthias Mörgelin | 75 | 332 | 18711 |
Constantinos C. Stoumpos | 75 | 194 | 27991 |
Raymond Alexanian | 75 | 211 | 21923 |
Mark J. Ablowitz | 74 | 374 | 27715 |
John Lygeros | 73 | 667 | 21508 |