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Institution

University of Patras

EducationPátrai, Greece
About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.


Papers
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Journal ArticleDOI
TL;DR: In this article, the dynamic response of infinitely long lined tunnels with a uniform cross-section buried into an elastic or viscoelastic half-space to body and surface harmonic seismic waves is numerically determined by a special direct boundary element method in the frequency domain.

170 citations

Journal Article
TL;DR: This paper reviews mobile location-based games for learning, focusing on their narrative structure, the interaction modes that they afford, their use of physical space as prop for action, the way this is linked to virtual space and the possible learning impact the game activities have.
Abstract: In this paper we review mobile location-based games for learning. These games are played in physical space, but at the same time, they are supported by actions and events in an interconnected virtual space. Learning in these games is related to issues like the narrative structure, space and game rules and content that define the virtual game space. First, we introduce the theoretical and empirical considerations of mobile location based games, and then we discuss an analytical framework of their main characteristics through typical examples. In particular, we focus on their narrative structure, the interaction modes that they afford, their use of physical space as prop for action, the way this is linked to virtual space and the possible learning impact the game activities have. Finally we conclude with an outline of future trends and possibilities that these kinds of playful activities can have on learning, especially outside school, like in environmental studies and visits in museums and other sites of cultural and historical value.

170 citations

Journal ArticleDOI
TL;DR: In this article, the effect of temperature on α-pinene secondary organic aerosol (SOA) mass fractions (AMF) was investigated in a temperature controlled smog chamber.
Abstract: [1] Despite a number of smog chamber studies of the α-pinene/O3 system, the effect of temperature on α-pinene secondary organic aerosol (SOA) mass fractions (or yields) remains poorly understood. In this study, the temperature dependence of secondary organic aerosol mass fractions (AMF) during ozonolysis of α-pinene is investigated in a temperature controlled smog chamber. Experiments were performed with and without ammonium sulfate aerosol seeds at RH < 10% and at 0°C, 15°C, 20°C, 30°C and 40°C. The initial α-pinene concentration varied from 3.5 to 50 ppb, and an excess of ozone was used. High time resolution secondary organic AMFs were obtained combining continuous gas-phase concentration measurements (using proton transfer reaction mass spectrometry, PTR-MS) with continuous aerosol concentration measurements (using a scanning mobility particle sizer, SMPS). The presence of inert aerosol seeds is often necessary to minimize experimental errors due to loss of semivolatile vapors to the walls of the chamber. The α-pinene secondary organic AMFs show a weak dependence on temperature in the 15° to 40°C range and stronger temperature dependence in the 0° and 15°C range.

169 citations

Journal ArticleDOI
TL;DR: The preliminary data suggest that in patients with dSSc and recent, clinically apparent alveolitis, early treatment with MMF and small doses of corticosteroids (CS) may represent an effective, well-tolerated and safe alternative therapy.
Abstract: Objective. To find an effective, safe immunosuppressive regimen as an alternative to cyclophosphamide (Cy) for the treatment of clinically evident diffuse scleroderma (dSSc)-associated alveolitis of recent onset. Methods. Five consecutive patients with dSSc and recent-onset alveolitis were enrolled and treated with mycophenolate mofetil (MMF) and small (·10 mg/day) doses of predinisolone in this open-label trial. One patient with long-standing fibrosing alveolitis was later added to our cohort. Pulmonary function tests [carbon monoxide diffusing capacity (DLCO) and forced vital capacity (FVC)], pulmonary high-resolution computed tomography (HRCT) scans and clinical assessment were performed before and at specified time-points after enrolment. Cases of significant infections, leucopenia and abdominal pain were recorded. Results. After 4–6 months of MMF therapy, DLCO improved significantly compared with pre-treatment (mean DLCO 75.4% vs 64.2% of predicted value, respectively, P^0.033). Values of FVC also improved, with the difference almost reaching levels of statistical significance (mean FVC 76.2% vs 65.6% of predicted value, P^0.057). Ground glass opacities cleared in three of four patients with recent-onset alveolitis and were reduced in one patient after 6–8 months of treatment. Breathlessness and cough improved by 3 months. A possible treatment failure was seen in one patient. However, in five patients functional and clinical improvement was sustained during the study period. No adverse events were recorded in this ongoing clinical trial. Conclusion. Our preliminary data suggest that in patients with dSSc and recent, clinically apparent alveolitis, early treatment with MMF and small doses of corticosteroids (CS) may represent an effective, well-tolerated and safe alternative therapy.

169 citations

Journal ArticleDOI
TL;DR: The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle’s physicochemical properties and by the particularities of the encountered biological milieu.
Abstract: With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein "bio-corona." The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle's physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.

169 citations


Authors

Showing all 13529 results

NameH-indexPapersCitations
Thomas J. Meyer120107868519
Thoralf M. Sundt11275555708
Chihaya Adachi11290861403
Eleftherios P. Diamandis110106452654
Roland Siegwart105115451473
T. Geralis9980852221
Spyros N. Pandis9737751660
Michael Tsapatsis7737520051
George K. Karagiannidis7665324066
Eleftherios Mylonakis7544821413
Matthias Mörgelin7533218711
Constantinos C. Stoumpos7519427991
Raymond Alexanian7521121923
Mark J. Ablowitz7437427715
John Lygeros7366721508
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022250
20211,738
20201,672
20191,469
20181,443