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Institution

University of Patras

EducationPátrai, Greece
About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.


Papers
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Journal ArticleDOI
01 May 2001-Thyroid
TL;DR: It is proposed that iodopeptide(s) are formed that temporarily inhibit thyroid peroxidase (TPO) mRNA and protein synthesis and, therefore, thyroglobulin iodinations.
Abstract: Iodine is an essential element for thyroid hormone synthesis. The thyroid gland has the capacity and holds the machinery to handle the iodine efficiently when the availability of iodine becomes scarce, as well as when iodine is available in excessive quantities. The latter situation is handled by the thyroid by acutely inhibiting the organification of iodine, the so-called acute Wolff-Chaikoff effect, by a mechanism not well understood 52 years after the original description. It is proposed that iodopeptide(s) are formed that temporarily inhibit thyroid peroxidase (TPO) mRNA and protein synthesis and, therefore, thyroglobulin iodinations. The Wolff-Chaikoff effect is an effective means of rejecting the large quantities of iodide and therefore preventing the thyroid from synthesizing large quantities of thyroid hormones. The acute Wolff-Chaikoff effect lasts for few a days and then, through the so-called "escape" phenomenon, the organification of intrathyroidal iodide resumes and the normal synthesis of thyroxine (T4) and triiodothyronine (T3) returns. This is achieved by decreasing the intrathyroidal inorganic iodine concentration by down regulation of the sodium iodine symporter (NIS) and therefore permits the TPO-H202 system to resume normal activity. However, in a few apparently normal individuals, in newborns and fetuses, in some patients with chronic systemic diseases, euthyroid patients with autoimmune thyroiditis, and Graves' disease patients previously treated with radioimmunoassay (RAI), surgery or antithyroid drugs, the escape from the inhibitory effect of large doses of iodides is not achieved and clinical or subclinical hypothyroidism ensues. Iodide-induced hypothyroidism has also been observed in patients with a history of postpartum thyroiditis, in euthyroid patients after a previous episode of subacute thyroiditis, and in patients treated with recombinant interferon-alpha who developed transient thyroid dysfunction during interferon-a treatment. The hypothyroidism is transient and thyroid function returns to normal in 2 to 3 weeks after iodide withdrawal, but transient T4 replacement therapy may be required in some patients. The patients who develop transient iodine-induced hypothyroidism must be followed long term thereafter because many will develop permanent primary hypothyroidism.

320 citations

Journal ArticleDOI
TL;DR: The International Axion Observatory (IAXO) as mentioned in this paper is the most powerful axion helioscope, reaching sensitivity to axion-photon couplings down to a few × 10−12 GeV−1 and thus probing a large fraction of the currently unexplored axion and ALP parameter space.
Abstract: The International Axion Observatory (IAXO) will be a forth generation axion helioscope. As its primary physics goal, IAXO will look for axions or axion-like particles (ALPs) originating in the Sun via the Primakoff conversion of the solar plasma photons. In terms of signal-to-noise ratio, IAXO will be about 4–5 orders of magnitude more sensitive than CAST, currently the most powerful axion helioscope, reaching sensitivity to axion-photon couplings down to a few × 10−12 GeV−1 and thus probing a large fraction of the currently unexplored axion and ALP parameter space. IAXO will also be sensitive to solar axions produced by mechanisms mediated by the axion-electron coupling gae with sensitivity — for the first time — to values of gae not previously excluded by astrophysics. With several other possible physics cases, IAXO has the potential to serve as a multi-purpose facility for generic axion and ALP research in the next decade. In this paper we present the conceptual design of IAXO, which follows the layout of an enhanced axion helioscope, based on a purpose-built 20 m-long 8-coils toroidal superconducting magnet. All the eight 60cm-diameter magnet bores are equipped with focusing x-ray optics, able to focus the signal photons into ~ 0.2 cm2 spots that are imaged by ultra-low-background Micromegas x-ray detectors. The magnet is built into a structure with elevation and azimuth drives that will allow for solar tracking for ~ 12 h each day.

318 citations

Journal ArticleDOI
24 May 2010-ACS Nano
TL;DR: The results show that graphenes embedded in plastic beams exhibit remarkable compression buckling strains, and calculations based on classical Euler analysis show that the buckling strain enhancement provided by the polymer lateral support is more than 6 orders of magnitude compared to that of suspended graphene in air.
Abstract: Central to most applications involving monolayer graphenes is its mechanical response under various stress states. To date most of the work reported is of theoretical nature and refers to tension and compression loading of model graphenes. Most of the experimental work is indeed limited to the bending of single flakes in air and the stretching of flakes up to typically ∼1% using plastic substrates. Recently we have shown that by employing a cantilever beam we can subject single graphenes to various degrees of axial compression. Here we extend this work much further by measuring in detail both stress uptake and compression buckling strain in single flakes of different geometries. In all cases the mechanical response is monitored by simultaneous Raman measurements through the shift of either the G or 2D phonons of graphene. Despite the infinitely small thickness of the monolayers, the results show that graphenes embedded in plastic beams exhibit remarkable compression buckling strains. For large length (l)-...

317 citations

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the electronic properties of nanocrystalline cerium oxide (CeO) films and established universal relations between them and the film structure, composition, and morphology.
Abstract: We investigate the electronic properties of nanocrystalline cerium oxide $({\mathrm{CeO}}_{x})$ films, grown by various techniques, and we establish universal relations between them and the film structure, composition, and morphology The nanocrystalline ${\mathrm{CeO}}_{x}$ films mainly consist of ${\mathrm{CeO}}_{2}$ grains, while a considerable concentration of trivalent ${\mathrm{Ce}}^{3+}$ is distributed at the ${\mathrm{CeO}}_{2}$ grain boundaries forming amorphous ${\mathrm{Ce}}_{2}{\mathrm{O}}_{3}$ A small portion of ${\mathrm{Ce}}^{3+}$ is also located around O-vacancy sites The optical properties of the ${\mathrm{CeO}}_{x}$ films are considered, taking into account the reported band-structure calculations The fundamental gap ${E}_{g}$ of ${\mathrm{CeO}}_{x}$ is due to the indirect $\mathrm{O}2\stackrel{\ensuremath{\rightarrow}}{p}\mathrm{Ce}4f$ electronic transition along the L high-symmetry lines of the Brillouin zone and it is correlated with the $[{\mathrm{Ce}}^{3+}]$ content, explaining the redshift of ${E}_{g}$ in nanostructured ${\mathrm{CeO}}_{x},$ which is due to the ${\mathrm{Ce}}^{3+}$ at the grain boundaries and not due to the quantum-size effect itself We also correlate the energy position of the $\mathrm{O}2\stackrel{\ensuremath{\rightarrow}}{p}\mathrm{Ce}4f$ electronic transition, which varies up to 160-meV wide, with the lattice constant of the ${\mathrm{CeO}}_{2}$ grains We also show that the higher-order transitions are more sensitive to film composition The refractive index, far below ${E}_{g},$ is explicitly correlated with the film density, independently of the ${\mathrm{Ce}}^{3+}/{\mathrm{Ce}}^{4+}$ and O concentrations, grain size, and lattice parameter The density is also found to be the major factor affecting the absolute value of the ${\ensuremath{\varepsilon}}_{2}$ peak, which corresponds to the $\mathrm{O}2\stackrel{\ensuremath{\rightarrow}}{p}\mathrm{Ce}4f$ electronic transition

316 citations

Journal ArticleDOI
TL;DR: In this paper, the theory of consolidation with double porosity is further substantiated by establishing certain general results concerning the mathematical behavior of the relevant partial differential equations, including uniqueness and a variational principle.

316 citations


Authors

Showing all 13529 results

NameH-indexPapersCitations
Thomas J. Meyer120107868519
Thoralf M. Sundt11275555708
Chihaya Adachi11290861403
Eleftherios P. Diamandis110106452654
Roland Siegwart105115451473
T. Geralis9980852221
Spyros N. Pandis9737751660
Michael Tsapatsis7737520051
George K. Karagiannidis7665324066
Eleftherios Mylonakis7544821413
Matthias Mörgelin7533218711
Constantinos C. Stoumpos7519427991
Raymond Alexanian7521121923
Mark J. Ablowitz7437427715
John Lygeros7366721508
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022250
20211,738
20201,672
20191,469
20181,443