Institution
University of Patras
Education•Pátrai, Greece•
About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.
Papers published on a yearly basis
Papers
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TL;DR: The complex ECM structure is emphasized as to provide a better understanding of its dynamic structural and functional multipotency and the implication of the various families of ECM macromolecules in health and disease is presented.
1,379 citations
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TL;DR: This minireview critically evaluates the role of MMPs in relation to cancer progression, and highlights the challenges, as well as future prospects, for the design, development and efficacy of M MPIs.
Abstract: Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis. In this regard, their activity plays a pivotal role in tumor growth and the multistep processes of invasion and metastasis, including proteolytic degradation of ECM, alteration of the cell-cell and cell-ECM interactions, migration and angiogenesis. The underlying premise of the current minireview is that MMPs are able to proteolytically process substrates in the extracellular milieu and, in so doing, promote tumor progression. However, certain members of the MMP family exert contradicting roles at different stages during cancer progression, depending among other factors on the tumor stage, tumor site, enzyme localization and substrate profile. MMPs are therefore amenable to therapeutic intervention by synthetic and natural inhibitors, providing perspectives for future studies. Multiple therapeutic agents, called matrix metalloproteinase inhibitors (MMPIs) have been developed to target MMPs, attempting to control their enzymatic activity. Even though clinical trials with these compounds do not show the expected results in most cases, the field of MMPIs is ongoing. This minireview critically evaluates the role of MMPs in relation to cancer progression, and highlights the challenges, as well as future prospects, for the design, development and efficacy of MMPIs.
1,373 citations
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TL;DR: A concise state-of-the-art survey of fiber-reinforced polymer composites for construction applications in civil engineering is presented in this article, which includes a historical review, the current state of the art, and future challenges.
Abstract: A concise state-of-the-art survey of fiber-reinforced polymer (also known as fiber-reinforced plastic) composites for construction applications in civil engineering is presented. The paper is organized into separate sections on structural shapes, bridge decks, internal reinforcements, externally bonded reinforcements, and standards and codes. Each section includes a historical review, the current state of the art, and future challenges.
1,367 citations
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TL;DR: Applications of Fullerenes, Carbon Dots, Nanotubes, Graphene, Nanodiamonds, and Combined Superstructures.
Abstract: and Applications of Fullerenes, Carbon Dots, Nanotubes, Graphene, Nanodiamonds, and Combined Superstructures Vasilios Georgakilas,† Jason A. Perman,‡ Jiri Tucek,‡ and Radek Zboril*,‡ †Material Science Department, University of Patras, 26504 Rio Patras, Greece ‡Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University in Olomouc, 17 listopadu 1192/12, 771 46 Olomouc, Czech Republic
1,366 citations
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TL;DR: Policies for managing plastic debris are outdated and threaten the health of people and wildlife, say Chelsea M Rochman, Mark Anthony Browne and colleagues.
Abstract: Policies for managing plastic debris are outdated and threaten the health of people and wildlife, say Chelsea M. Rochman, Mark Anthony Browne and colleagues.
1,130 citations
Authors
Showing all 13529 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thomas J. Meyer | 120 | 1078 | 68519 |
Thoralf M. Sundt | 112 | 755 | 55708 |
Chihaya Adachi | 112 | 908 | 61403 |
Eleftherios P. Diamandis | 110 | 1064 | 52654 |
Roland Siegwart | 105 | 1154 | 51473 |
T. Geralis | 99 | 808 | 52221 |
Spyros N. Pandis | 97 | 377 | 51660 |
Michael Tsapatsis | 77 | 375 | 20051 |
George K. Karagiannidis | 76 | 653 | 24066 |
Eleftherios Mylonakis | 75 | 448 | 21413 |
Matthias Mörgelin | 75 | 332 | 18711 |
Constantinos C. Stoumpos | 75 | 194 | 27991 |
Raymond Alexanian | 75 | 211 | 21923 |
Mark J. Ablowitz | 74 | 374 | 27715 |
John Lygeros | 73 | 667 | 21508 |