Institution
University of Patras
Education•Pátrai, Greece•
About: University of Patras is a education organization based out in Pátrai, Greece. It is known for research contribution in the topics: Population & Catalysis. The organization has 13372 authors who have published 31263 publications receiving 677159 citations. The organization is also known as: Panepistímio Patrón.
Papers published on a yearly basis
Papers
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TL;DR: The proposed system demonstrated that it is possible to deploy a cost-effective and reliable real-time data collection, processing, and analysis from the shop floor and demonstrates that such collected data can be used in an adaptive decision making system, which includes a multi-criteria decision-making algorithm and a condition-based maintenance strategy aiming to improve factory performances when compared to traditional approaches.
205 citations
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TL;DR: Results show that molecular adaptations to chronic morphine alter CRE-mediated transcription during opiate withdrawal in physiologically salient regions involved in arousal, reward, mood, and affective responses and propose that CRE- mediated transcription serves as a functional marker for neuronal plasticity during withdrawal.
Abstract: Chronic opiate exposure is associated with upregulation of the cAMP signaling pathway and the transcription factor cAMP response element-binding protein in the locus ceruleus (LC) and certain other brain areas. To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal. Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN). In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses. At the cellular level, in the central nucleus of the amygdala, beta-gal was found in cells both with and without mu opioid receptors as well as in corticotropin-releasing factor-expressing cells. In nucleus accumbens, beta-gal was expressed in several major subpopulations of neurons. In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic. These results show that molecular adaptations to chronic morphine alter CRE-mediated transcription during opiate withdrawal in physiologically salient regions involved in arousal, reward, mood, and affective responses. We propose that CRE-mediated transcription serves as a functional marker for neuronal plasticity during withdrawal. CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions.
204 citations
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TL;DR: Learning factories present a promising environment for education, training and research, especially in manufacturing related areas which are a main driver for wealth creation in any nation as mentioned in this paper. But, while n...
204 citations
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TL;DR: First, patients’ serum Ang‐2 levels are increased during severe sepsis and associated with disease severity, and the strong relationship of serum angiopoietin with serum tumor necrosis factor‐&agr; suggests that the latter may participate in the regulation of Ang‐ 2 production in sepsi.
Abstract: Objective:Angiopoietin (Ang)-2 is an endothelium-specific growth factor, regulated by proinflammatory stimuli, that destabilizes vascular endothelium and increases vascular leakage; consequently, Ang-2 may contribute to sepsis pathophysiology. We have studied 1) serum Ang-2 levels in critically-ill
204 citations
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TL;DR: The more ecological, anti-herbivore hypotheses, consider red leaf color as a signal denoting high defensive commitment, as a camouflage obscuring the green reflectance indicative of a healthy leaf and/or as a device undermining the folivorous insects camouflage.
203 citations
Authors
Showing all 13529 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thomas J. Meyer | 120 | 1078 | 68519 |
Thoralf M. Sundt | 112 | 755 | 55708 |
Chihaya Adachi | 112 | 908 | 61403 |
Eleftherios P. Diamandis | 110 | 1064 | 52654 |
Roland Siegwart | 105 | 1154 | 51473 |
T. Geralis | 99 | 808 | 52221 |
Spyros N. Pandis | 97 | 377 | 51660 |
Michael Tsapatsis | 77 | 375 | 20051 |
George K. Karagiannidis | 76 | 653 | 24066 |
Eleftherios Mylonakis | 75 | 448 | 21413 |
Matthias Mörgelin | 75 | 332 | 18711 |
Constantinos C. Stoumpos | 75 | 194 | 27991 |
Raymond Alexanian | 75 | 211 | 21923 |
Mark J. Ablowitz | 74 | 374 | 27715 |
John Lygeros | 73 | 667 | 21508 |