Institution
University of Pavia
Education•Pavia, Italy•
About: University of Pavia is a education organization based out in Pavia, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 21173 authors who have published 52524 publications receiving 1610492 citations. The organization is also known as: Università degli Studi di Pavia & Università di Pavia.
Topics: Population, Large Hadron Collider, Transplantation, CMOS, Lepton
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Stanford University1, University of Göttingen2, University of Texas MD Anderson Cancer Center3, University of Rochester Medical Center4, St James's University Hospital5, University of Paris6, University of Düsseldorf7, University of Pavia8, Medical University of Vienna9, University of Chicago10, Quest Diagnostics11, University of Freiburg12, Cleveland Clinic13, Federal University of Ceará14, Nagasaki University15, University of Dundee16, VU University Medical Center17
TL;DR: This revised IPSS-R comprehensively integrated the numerous known clinical features into a method analyzing MDS patient prognosis more precisely than the initial IPSS and should prove beneficial for predicting the clinical outcomes of untreated MDS patients and aiding design and analysis of clinical trials in this disease.
2,310 citations
TL;DR: These experiments show that for mammals, nuclei from terminally differentiated, adult somatic cells of known phenotype introduced into enucleated oocytes are capable of supporting full development.
Abstract: Until recently, fertilization was the only way to produce viable mammalian offspring, a process implicitly involving male and female gametes. However, techniques involving fusion of embryonic or fetal somatic cells with enucleated oocytes have become steadily more successful in generating cloned young. Dolly the sheep was produced by electrofusion of sheep mammary-derived cells with enucleated sheep oocytes. Here we investigate the factors governing embryonic development by introducing nuclei from somatic cells (Sertoli, neuronal and cumulus cells) taken from adult mice into enucleated mouse oocytes. We found that some enucleated oocytes receiving Sertoli or neuronal nuclei developed in vitro and implanted following transfer, but none developed beyond 8.5 days post coitum; however, a high percentage of enucleated oocytes receiving cumulus nuclei developed in vitro. Once transferred, many of these embryos implanted and, although most were subsequently resorbed, a significant proportion (2 to 2.8%) developed to term. These experiments show that for mammals, nuclei from terminally differentiated, adult somatic cells of known phenotype introduced into enucleated oocytes are capable of supporting full development.
2,227 citations
TL;DR: A joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetes in Toronto, Canada, 13-18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies as mentioned in this paper.
Abstract: Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic Neuropathy in Toronto, Canada, 13-18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies (DPNs), autonomic neuropathy, painful DPNs, and structural alterations in DPNs.
1,922 citations
Rockefeller University1, University of Paris2, French Institute of Health and Medical Research3, National Institutes of Health4, University of Tartu5, Lyon College6, Tartu University Hospital7, Utrecht University8, Vita-Salute San Raffaele University9, Yale University10, Pasteur Institute11, Collège de France12, University of Amsterdam13, McGill University Health Centre14, Garvan Institute of Medical Research15, University of New South Wales16, Ghent University Hospital17, University of Barcelona18, Catalan Institution for Research and Advanced Studies19, University of Vic20, Science for Life Laboratory21, Karolinska University Hospital22, Howard Hughes Medical Institute23, Aarhus University Hospital24, Aarhus University25, University of Milano-Bicocca26, University of Lorraine27, Karolinska Institutet28, Haukeland University Hospital29, University of Bergen30, Canadian Real Estate Association31, University of Brescia32, University of Pavia33
TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
Abstract: Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
1,913 citations
TL;DR: A measurement of the frequency shift of radio photons to and from the Cassini spacecraft as they passed near the Sun agrees with the predictions of standard general relativity with a sensitivity that approaches the level at which, theoretically, deviations are expected in some cosmological models.
Abstract: According to general relativity, photons are deflected and delayed by the curvature of space-time produced by any mass. The bending and delay are proportional to gamma + 1, where the parameter gamma is unity in general relativity but zero in the newtonian model of gravity. The quantity gamma - 1 measures the degree to which gravity is not a purely geometric effect and is affected by other fields; such fields may have strongly influenced the early Universe, but would have now weakened so as to produce tiny--but still detectable--effects. Several experiments have confirmed to an accuracy of approximately 0.1% the predictions for the deflection and delay of photons produced by the Sun. Here we report a measurement of the frequency shift of radio photons to and from the Cassini spacecraft as they passed near the Sun. Our result, gamma = 1 + (2.1 +/- 2.3) x 10(-5), agrees with the predictions of standard general relativity with a sensitivity that approaches the level at which, theoretically, deviations are expected in some cosmological models.
1,882 citations
Authors
Showing all 21348 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Giacomo Bruno | 158 | 1687 | 124368 |
| Melody A. Swartz | 148 | 1304 | 103753 |
| Peter J. Schwartz | 147 | 647 | 107695 |
| Marco Zanetti | 145 | 1439 | 104610 |
| Th. Müller | 144 | 1798 | 125843 |
| Chiara Mariotti | 141 | 1426 | 98157 |
| Silvia G. Priori | 140 | 515 | 120642 |
| Kevin Varvell | 138 | 1325 | 93740 |
| Alberto Messineo | 134 | 1511 | 96492 |
| Franco Ligabue | 134 | 1404 | 95389 |
| Michele Arneodo | 134 | 1339 | 93977 |
| Roberto Tenchini | 133 | 1390 | 94541 |
| Bruce Yabsley | 133 | 1191 | 84889 |
| Philip McGuire | 133 | 881 | 60813 |
| Antonio Limosani | 133 | 1181 | 83668 |