Institution
University of Perugia
Education•Perugia, Umbria, Italy•
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.
Topics: Population, Large Hadron Collider, Immune system, Medicine, Catalysis
Papers published on a yearly basis
Papers
More filters
TL;DR: Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain.
Abstract: In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease-the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.
313 citations
University of Milan1, University of Hamburg2, Virginia Tech3, University of Massachusetts Amherst4, Princeton University5, Moscow State University6, Petersburg Nuclear Physics Institute7, Kurchatov Institute8, National Research Nuclear University MEPhI9, Joint Institute for Nuclear Research10, University of Paris11, University of Genoa12, Technische Universität München13, University of Houston14, Max Planck Society15, Jagiellonian University16, University of Perugia17, University of California, Los Angeles18, University of Mainz19
TL;DR: Spectral observations of pp neutrinos are reported, demonstrating that about 99 per cent of the power of the Sun, 3.84 × 1033 ergs per second, is generated by the proton–proton fusion process.
Abstract: Spectral observations of the low-energy neutrinos produced by proton–proton fusion in the Sun demonstrate that about 99 per cent of the Sun’s power is generated by this process.
313 citations
TL;DR: The scientific research conducted so far has not detected any significant hazards directly connected with the use of GE crops; however, the debate is still intense and an improvement in the efficacy of scientific communication could have a significant impact on the future of agricultural GE.
Abstract: The technology to produce genetically engineered (GE) plants is celebrating its 30th anniversary and one of the major achievements has been the development of GE crops. The safety of GE crops is cr...
312 citations
17 Jan 2014
TL;DR: In this article, a search for the standard model Higgs boson decaying to a W-boson pair at the LHC is reported, and an excess of events above background is observed.
Abstract: A search for the standard model Higgs boson decaying to a W-boson pair at the LHC is reported. The event sample corresponds to an integrated luminosity of 4.9 fb−1 and 19.4 fb−1 collected with the CMS detector in pp collisions at s√ = 7 and 8 TeV, respectively. The Higgs boson candidates are selected in events with two or three charged leptons. An excess of events above background is observed, consistent with the expectation from the standard model Higgs boson with a mass of around 125 GeV. The probability to observe an excess equal or larger than the one seen, under the background-only hypothesis, corresponds to a significance of 4.3 standard deviations for m H = 125.6 GeV. The observed signal cross section times the branching fraction to WW for m H = 125.6 GeV is 0.72+0.20−0.18 times the standard model expectation. The spin-parity J P = 0+ hypothesis is favored against a narrow resonance with J P = 2+ or J P = 0− that decays to a W-boson pair. This result provides strong evidence for a Higgs-like boson decaying to a W-boson pair.
312 citations
TL;DR: It is demonstrated that MSCs recruit, regulate, and maintain T-regulatory phenotype and function over time.
312 citations
Authors
Showing all 13488 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Grätzel | 248 | 1423 | 303599 |
| Luigi Ferrucci | 193 | 1601 | 181199 |
| Tobin J. Marks | 159 | 1621 | 111604 |
| Johan Auwerx | 158 | 653 | 95779 |
| Tony Pawson | 150 | 425 | 85196 |
| Jack Hirsh | 146 | 734 | 86332 |
| Alexander Belyaev | 142 | 1895 | 100796 |
| R. L. McCarthy | 141 | 1238 | 115696 |
| Harvey B Newman | 139 | 1594 | 88308 |
| Guido Tonelli | 138 | 1458 | 97248 |
| Elias Campo | 135 | 761 | 85160 |
| Alberto Messineo | 134 | 1511 | 96492 |
| Franco Ligabue | 134 | 1404 | 95389 |
| Roberto Tenchini | 133 | 1390 | 94541 |
| R. Bartoldus | 132 | 1624 | 97405 |