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Institution

University of Perugia

EducationPerugia, Umbria, Italy
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.


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Journal ArticleDOI
TL;DR: The authors' series confirms the downward trend in mortality rates reported in previous series, with all new drugs providing similar survival and response rates.
Abstract: Background The aim of this study was to evaluate prognostic factors, treatments and outcome of invasive aspergillosis in patients with acute myeloid leukemia based on data collected in a registry. Design and Methods The registry, which was activated in 2004 and closed in 2007, collected data on patients with acute myeloid leukemia, admitted to 21 hematologic divisions in tertiary care centers or university hospitals in Italy, who developed proven or probable invasive aspergillosis. Results One hundred and forty cases of invasive aspergillosis were collected, with most cases occurring during the period of post-induction aplasia, the highest risk phase in acute myeloid leukemia. The mortality rate attributable to invasive aspergillosis was 27%, confirming previous reports of a downward trend in this rate. Univariate and multivariate analyses revealed that the stage of acute myeloid leukemia and the duration of, and recovery from, neutropenia were independent prognostic factors. We analyzed outcomes after treatment with the three most frequently used drugs (liposomal amphotericin B, caspofungin, voriconazole). No differences emerged in survival at day 120 or in the overall response rate which was 71%, ranging from 61% with caspofungin to 84% with voriconazole. Conclusions Our series confirms the downward trend in mortality rates reported in previous series, with all new drugs providing similar survival and response rates. Recovery from neutropenia and disease stage are crucial prognostic factors. Efficacious antifungal drugs bridge the period of maximum risk due to poor hematologic and immunological reconstitution.

280 citations

Journal ArticleDOI
TL;DR: In apparently healthy patients with essential hypertension, LVH diagnosed by ECG or echocardiography confers an excess risk for stroke and transient ischemic attack independently of BP and other individual risk factors.
Abstract: Background It is uncertain whether left ventricular hypertrophy (LVH) confers an increased risk for cerebrovascular disease in apparently healthy patients with essential hypertension. Methods and Results A total of 2363 initially untreated hypertensive patients (mean age 51±12 years, 47% women) free of previous cardiovascular disease were followed up for up to 14 years (mean 5 years). At entry, all patients underwent diagnostic tests, including ECG, echocardiography, and 24-hour ambulatory blood pressure (BP) monitoring. At entry, the prevalence of LVH was 17.6% by ECG (Perugia score) and 23.7% by echocardiography (LVM >125 g/m2). Over the subsequent years, 105 patients experienced a first stroke or transient ischemic attack. The cerebrovascular event rate was higher among patients with LVH at entry, diagnosed by either ECG or echocardiography, than among those without hypertrophy (both P<0.01). After control for the significant influence of age, sex, diabetes, and 24-hour mean ambulatory BP, LVH by ECG c...

280 citations

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, Richard J. Abbott2, T. D. Abbott3  +1064 moreInstitutions (117)
TL;DR: This work performs a search for the isotropic stochastic gravitational-wave background using data from Advanced Laser Interferometer Gravitational Wave Observatory's (aLIGO) first observing run, and constrain the dimensionless energy density of gravitational waves to be Ω_{0}<1.7×10^{-7} with 95% confidence.
Abstract: A wide variety of astrophysical and cosmological sources are expected to contribute to a stochastic gravitational-wave background. Following the observations of GW150914 and GW151226, the rate and mass of coalescing binary black holes appear to be greater than many previous expectations. As a result, the stochastic background from unresolved compact binary coalescences is expected to be particularly loud. We perform a search for the isotropic stochastic gravitational-wave background using data from Advanced Laser Interferometer Gravitational Wave Observatory’s (aLIGO) first observing run. The data display no evidence of a stochastic gravitational-wave signal. We constrain the dimensionless energy density of gravitational waves to be Ω 0 < 1.7 × 10 − 7 with 95% confidence, assuming a flat energy density spectrum in the most sensitive part of the LIGO band (20–86 Hz). This is a factor of ∼ 33 times more sensitive than previous measurements. We also constrain arbitrary power-law spectra. Finally, we investigate the implications of this search for the background of binary black holes using an astrophysical model for the background.

280 citations

Journal ArticleDOI
01 May 2015-Brain
TL;DR: The use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage and the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis are supported.
Abstract: Three sets of research criteria are available for diagnosis of Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognitive impairment (n = 1607), 766 of whom had both amyloid and neuronal injury markers, were recruited from 13 cohorts. We used cognitive test performance and available biomarkers to classify subjects as prodromal Alzheimer's disease according to International Working Group-1 and International Working Group-2 criteria and in the high Alzheimer's disease likelihood group, conflicting biomarker groups (isolated amyloid pathology or suspected non-Alzheimer pathophysiology), and low Alzheimer's disease likelihood group according to the National Institute of Ageing-Alzheimer Association criteria. Outcome measures were the proportion of subjects with Alzheimer's disease at the mild cognitive impairment stage and progression to Alzheimer's disease-type dementia. We performed survival analyses using Cox proportional hazards models. According to the International Working Group-1 criteria, 850 (53%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 50% compared to 21% for subjects without prodromal Alzheimer's disease. According to the International Working Group-2 criteria, 308 (40%) subjects had prodromal Alzheimer's disease. Their 3-year progression rate to Alzheimer's disease-type dementia was 61% compared to 22% for subjects without prodromal Alzheimer's disease. According to the National Institute of Ageing-Alzheimer Association criteria, 353 (46%) subjects were in the high Alzheimer's disease likelihood group, 49 (6%) in the isolated amyloid pathology group, 220 (29%) in the suspected non-Alzheimer pathophysiology group, and 144 (19%) in the low Alzheimer's disease likelihood group. The 3-year progression rate to Alzheimer's disease-type dementia was 59% in the high Alzheimer's disease likelihood group, 22% in the isolated amyloid pathology group, 24% in the suspected non-Alzheimer pathophysiology group, and 5% in the low Alzheimer's disease likelihood group. Our findings support the use of the proposed research criteria to identify Alzheimer's disease at the mild cognitive impairment stage. In clinical settings, the use of both amyloid and neuronal injury markers as proposed by the National Institute of Ageing-Alzheimer Association criteria offers the most accurate prognosis. For clinical trials, selection of subjects in the National Institute of Ageing-Alzheimer Association high Alzheimer's disease likelihood group or the International Working Group-2 prodromal Alzheimer's disease group could be considered.

279 citations

Journal ArticleDOI
TL;DR: The blazar 3C 279, one of the brightest identified extragalactic objects in the γ-ray sky, underwent a large (factor of ~10 in amplitude) flare in γ rays toward the end of a 3 week pointing by Compton Gamma Ray Observatory (CGRO), in 1996 January-February.
Abstract: The blazar 3C 279, one of the brightest identified extragalactic objects in the γ-ray sky, underwent a large (factor of ~10 in amplitude) flare in γ-rays toward the end of a 3 week pointing by Compton Gamma Ray Observatory (CGRO), in 1996 January-February. The flare peak represents the highest γ-ray intensity ever recorded for this object. During the high state, extremely rapid γ-ray variability was seen, including an increase of a factor of 2.6 in ~8 hr, which strengthens the case for relativistic beaming. Coordinated multifrequency observations were carried out with Rossi X-Ray Timing Explorer (RXTE), Advanced Satellite for Cosmology and Astrophysics (ASCA; or, Astro-D), Roentgen Satellite (ROSAT), and International Ultraviolet Explorer (IUE) and from many ground-based observatories, covering most accessible wavelengths. The well-sampled, simultaneous RXTE light curve shows an outburst of lower amplitude (factor of simeq3) well correlated with the γ-ray flare without any lag larger than the temporal resolution of ~1 day. The optical-UV light curves, which are not well sampled during the high-energy flare, exhibit more modest variations (factor of ~2) and a lower degree of correlation. The flux at millimetric wavelengths was near a historical maximum during the γ-ray flare peak, and there is a suggestion of a correlated decay. We present simultaneous spectral energy distributions of 3C 279 prior to and near to the flare peak. The γ-rays vary by more than the square of the observed IR-optical flux change, which poses some problems for specific blazar emission models. The synchrotron self-Compton (SSC) model would require that the largest synchrotron variability occurred in the mostly unobserved submillimeter/far-infrared region. Alternatively, a large variation in the external photon field could occur over a timescale of a few days. This occurs naturally in the "mirror" model, wherein the flaring region in the jet photoionizes nearby broad emission line clouds, which, in turn, provide soft external photons that are Comptonized to γ-ray energies.

279 citations


Authors

Showing all 13488 results

NameH-indexPapersCitations
Michael Grätzel2481423303599
Luigi Ferrucci1931601181199
Tobin J. Marks1591621111604
Johan Auwerx15865395779
Tony Pawson15042585196
Jack Hirsh14673486332
Alexander Belyaev1421895100796
R. L. McCarthy1411238115696
Harvey B Newman139159488308
Guido Tonelli138145897248
Elias Campo13576185160
Alberto Messineo134151196492
Franco Ligabue134140495389
Roberto Tenchini133139094541
R. Bartoldus132162497405
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023108
2022226
20212,487
20202,594
20192,362
20182,274