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Institution

University of Perugia

EducationPerugia, Umbria, Italy
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-s 1-42 (Aβ 42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD) was identified.
Abstract: Background We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-s 1-42 (Aβ 42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD). Methods We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/Aβ 42 ratio and 0.08 for the p-tau/Aβ 42 ratio. Ratios performed similar to formulas (sensitivity, 91%–93%; specificity, 81%–84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/Aβ 42 ratio. Conclusions A tau/Aβ 42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.

262 citations

Journal ArticleDOI
TL;DR: Findings indicate that two potential oncogenic proteins are generated by the acute promyelocytic leukaemia (APL) 15;17 translocation and suggest that the PML activation pathway is altered in APLs.
Abstract: The acute promyelocytic leukaemia (APL) 15;17 translocation generates a PML/RAR alpha chimeric gene which is transcribed as a fusion PML/RAR alpha mRNA. Molecular studies on a large series of APLs revealed great heterogeneity of the PML/RAR alpha transcripts due to: (i) variable breaking of chromosome 15 within three PML breakpoint cluster regions (bcr1, bcr2 and bcr3), (ii) alternative splicings of the PML portion and (iii) alternative usage of two RAR alpha polyadenylation sites. Nucleotide sequence analysis predicted two types of proteins: multiple PML/RAR alpha and aberrant PML. The PML/RAR alpha proteins varied among bcr1, 2 and 3 APL cases and within single cases. The fusion proteins contained variable portions of the PML N terminus joined to the B-F RAR alpha domains; the only PML region retained was the putative DNA binding domain. The aberrant PML proteins lacked the C terminus, which had been replaced by from two to ten amino acid residues from the RAR alpha sequence. Multiple PML/RAR alpha isoforms and aberrant PML proteins were found to coexist in all APLs. These findings indicate that two potential oncogenic proteins are generated by the t(15;17) and suggest that the PML activation pathway is altered in APLs.

262 citations

Journal ArticleDOI
TL;DR: In this paper, conditional sequential Gaussian simulations (sGs) have been applied for the first time to the study of soil diffuse degassing from different volcanic and nonvolcanic systems.
Abstract: [1] Conditional sequential Gaussian simulations (sGs) have been applied for the first time to the study of soil diffuse degassing from different volcanic and nonvolcanic systems. The application regards five data sets of soil CO2 fluxes measured with the accumulation chamber methodology at the volcanic areas of Solfatara of Pozzuoli (Italy), Vesuvio cone (Italy), Nisyros (Greece), and Horseshoe Lake (California) and at the nonvolcanic degassing area of Poggio dell'Olivo (Italy). The sGs algorithm was used to generate 100 realizations of CO2 flux for each area. Probabilistic summaries of these simulations, together with the information given by probability plots, were used (1) to draw maps of the probability that CO2 fluxes exceed thresholds specific for a background flux, i.e., to define the probable extension of the degassing structures, (2) to calculate the total CO2 output, and (3) to quantify the uncertainty of the estimation. The results show that the sGs is a suitable tool to model soil diffuse degassing, producing realistic images of the distribution of the CO2 fluxes that honor the histogram and variogram of the original data. Moreover, the relation between the sample design and the uncertainty of estimation was investigated leading to an empirical relation between uncertainty and the sampling density that can be useful for the planning of future CO2 flux surveys.

261 citations

Journal ArticleDOI
TL;DR: The early Toarcian Oceanic Anoxic Event (T-OAE) was a global event of environmental and carbon cycle perturbations, which deeply affected both marine biota and carbonate production as discussed by the authors.

261 citations


Authors

Showing all 13488 results

NameH-indexPapersCitations
Michael Grätzel2481423303599
Luigi Ferrucci1931601181199
Tobin J. Marks1591621111604
Johan Auwerx15865395779
Tony Pawson15042585196
Jack Hirsh14673486332
Alexander Belyaev1421895100796
R. L. McCarthy1411238115696
Harvey B Newman139159488308
Guido Tonelli138145897248
Elias Campo13576185160
Alberto Messineo134151196492
Franco Ligabue134140495389
Roberto Tenchini133139094541
R. Bartoldus132162497405
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023108
2022226
20212,487
20202,594
20192,362
20182,274