University of Perugia

About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.

The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria.

Abstract: This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease

Abstract: Objectives: To evaluate levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA, in peripheral lymphocytes; to measure plasma concentrations of several nonenzymatic antioxidants; and to assess the relationships between any observed changes in lymphocyte DNA 8-OHdG content and plasma antioxidant levels in patients with AD and healthy aged control subjects. Subjects: Forty elderly outpatients with AD and 39 healthy age- and sex-matched controls were studied. Main Outcome Measures: The level of 8-OHdG was determined in DNA extracted from lymphocytes and plasma levels of vitamin C, vitamin A, vitamin E, and carotenoids (zeaxanthin, -cryptoxanthin, lycopene, lutein, and -a nd-carotene) were measured by highperformance liquid chromatography. Results: Lymphocyte DNA 8-OHdG content was significantly higher and plasma levels of antioxidants (with the exception of lutein) were significantly lower in patients with AD compared with controls. In patients with AD, a significant inverse relationship between lymphocyte DNA 8-OHdG content and plasma levels of lycopene, lutein,-carotene, and-carotene, respectively, was observed. Conclusions: Markers of oxidative damage are increased in AD and correlate with decreased levels of plasma antioxidants. These findings suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a condition of increased oxidative stress related to a poor antioxidant status. Arch Neurol. 2002;59:794-798

Upper Limits on the Rates of Binary Neutron Star and Neutron Star-Black Hole Mergers from Advanced LIGO’s First Observing Run

Abstract: We report here the non-detection of gravitational waves from the merger of binary–neutron star systems and neutron star–black hole systems during the first observing run of the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO). In particular, we searched for gravitational-wave signals from binary–neutron star systems with component masses $\in [1,3]\,{M}_{\odot }$ and component dimensionless spins <0.05. We also searched for neutron star–black hole systems with the same neutron star parameters, black hole mass $\in [2,99]\,{M}_{\odot }$, and no restriction on the black hole spin magnitude. We assess the sensitivity of the two LIGO detectors to these systems and find that they could have detected the merger of binary–neutron star systems with component mass distributions of 1.35 ± 0.13 M ⊙ at a volume-weighted average distance of ~70 Mpc, and for neutron star–black hole systems with neutron star masses of 1.4 M ⊙ and black hole masses of at least 5 M ⊙, a volume-weighted average distance of at least ~110 Mpc. From this we constrain with 90% confidence the merger rate to be less than 12,600 Gpc−3 yr−1 for binary–neutron star systems and less than 3600 Gpc−3 yr−1 for neutron star–black hole systems. We discuss the astrophysical implications of these results, which we find to be in conflict with only the most optimistic predictions. However, we find that if no detection of neutron star–binary mergers is made in the next two Advanced LIGO and Advanced Virgo observing runs we would place significant constraints on the merger rates. Finally, assuming a rate of ${10}_{-7}^{+20}$ Gpc−3 yr−1, short gamma-ray bursts beamed toward the Earth, and assuming that all short gamma-ray bursts have binary–neutron star (neutron star–black hole) progenitors, we can use our 90% confidence rate upper limits to constrain the beaming angle of the gamma-ray burst to be greater than $2\buildrel{\circ}\over{.} {3}_{-1.1}^{+1.7}$ ($4\buildrel{\circ}\over{.} {3}_{-1.9}^{+3.1}$).