Institution
University of Perugia
Education•Perugia, Umbria, Italy•
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.
Topics: Population, Large Hadron Collider, Immune system, Medicine, Catalysis
Papers published on a yearly basis
Papers
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TL;DR: The data indicate that the production of IL-4 by Th2 cells may limit Th1-associated protective immunity in murine candidiasis, which is associated with efficient clearance of the yeast from infected organs and histologic evidence of disease resolution.
Abstract: An interleukin 4 (IL-4)-specific monoclonal antibody (mAb) was administered to mice infected systemically with the yeast Candida albicans, and the animals were monitored for mortality, development of delayed-type hypersensitivity, production of antibodies of different isotypes, release of IL-2, IL-4, IL-6, and interferon gamma (IFN-gamma) in vitro by splenic CD4+ lymphocytes, and levels of IL-4 and IFN-gamma mRNA in these cells. Neutralization of IL-4 by three weekly injections of mAb in several independent experiments resulted in an overall cure rate of 81% versus 0% of controls. Cure was associated with efficient clearance of the yeast from infected organs and histologic evidence of disease resolution, detection of strong T helper type 1 (Th1) responses, and establishment of long-lasting protective immunity. Soon after infection, and as a result of the first or second injection of mAb, there was a decrease in IL-4 mRNA in CD4+ cells, which was accompanied by an increase in the levels of IFN-gamma-specific transcripts. Our data thus indicate that the production of IL-4 by Th2 cells may limit Th1-associated protective immunity in murine candidiasis.
207 citations
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TL;DR: In this article, the applicability of carbon nanotube-cement-based sensors for measuring dynamically varying strain in concrete structures is explored, and the results demonstrate that the sensors output retains all dynamic features of the input thus providing useful information for SHM and encouraging the transformation of structures into infinite sets of potential sensors with enhanced durability and limited access issues.
Abstract: A new type of sensor for structural health monitoring (SHM) has emerged since the birth and development of nanotechnology and is based on cementitious materials additioned with carbon nanoparticles that can provide measurable electrical responses to applied strain. The response of similar transducers was mainly investigated under slowly varying strains while applications in dynamics have not been yet documented. This paper is aimed at exploring the applicability of carbon nanotube–cement based sensors for measuring dynamically varying strain in concrete structures. Experiments are presented to investigate the electrical response of prismatic specimens made of carbon nanotube–cement composite when subjected to sinusoidal stress–strains in the typical frequency range of large civil structures. The results demonstrate that the sensors’ output retains all dynamic features of the input thus providing useful information for SHM and encouraging the transformation of structures into infinite sets of potential sensors with enhanced durability and limited access issues.
207 citations
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TL;DR: The structure and functions of NPM are reviewed, as well as the biological, clinical and pathological features of human hematologic malignancies with NPM1 gene alterations, which indentifies a new category of T/Null lymphomas with distinctive molecular and clinico-pathological features.
Abstract: Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phoshoprotein which shuttles continuously between the nucleus and cytoplasm. Many findings have revealed a complex scenario of NPM functions and interactions, pointing to proliferative and growth-suppressive roles of this molecule. The gene NPM1 that encodes for nucleophosmin (NPM1) is translocated or mutated in various lymphomas and leukemias, forming fusion proteins (NPM-ALK, NPM-RARalpha, NPM-MLF1) or NPM mutant products. Here, we review the structure and functions of NPM, as well as the biological, clinical and pathological features of human hematologic malignancies with NPM1 gene alterations. NPM-ALK indentifies a new category of T/Null lymphomas with distinctive molecular and clinico-pathological features, that is going to be included as a novel disease entity (ALK+ anaplastic large cell lymphoma) in the new WHO classification of lymphoid neoplasms. NPM1 mutations occur specifically in about 30% of adult de novo AML and cause aberrant cytoplasmic expression of NPM (hence the term NPMc+ AML). NPMc+ AML associates with normal karyotpe, and shows wide morphological spectrum, multilineage involvement, a unique gene expression signature, a high frequency of FLT3-internal tandem duplications, and distinctive clinical and prognostic features. The availability of specific antibodies and molecular techniques for the detection of NPM1 gene alterations has an enormous impact in the biological study diagnosis, prognostic stratification, and monitoring of minimal residual disease of various lymphomas and leukemias. The discovery of NPM1 gene alterations also represents the rationale basis for development of molecular targeted drugs.
207 citations
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01 Mar 2019TL;DR: Major inequalities in acute stroke treatment between and within 44 European countries are observed, which will assist decision makers implementing tailored stroke care programmes for reducing stroke-related morbidity and mortality in Europe.
Abstract: IntroductionAcute stroke unit care, intravenous thrombolysis and endovascular treatment significantly improve the outcome for patients with ischaemic stroke, but data on access and delivery through...
207 citations
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University of Minnesota1, Texas A&M University2, Swedish University of Agricultural Sciences3, University of Kentucky4, University of California, Davis5, Sao Paulo State University6, University College Dublin7, University of the Azores8, University of Veterinary Medicine Vienna9, University of Perugia10, Animal Health Trust11, University of Sydney12, University of Helsinki13, University of Bern14, Royal Veterinary College15, Norwegian University of Life Sciences16
TL;DR: The use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity is described, providing new insights into the relationships among and the diversity within breeds of horses.
Abstract: Horses were domesticated from the Eurasian steppes 5,000–6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed across the world, many of which have become or are in the process of becoming formally organized into closed, breeding populations (breeds). This report describes the use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity. FST calculations, parsimony, and distance analysis demonstrated relationships among the breeds that largely reflect geographic origins and known breed histories. Low levels of population divergence were observed between breeds that are relatively early on in the process of breed development, and between those with high levels of within-breed diversity, whether due to large population size, ongoing outcrossing, or large within-breed phenotypic diversity. Populations with low within-breed diversity included those which have experienced population bottlenecks, have been under intense selective pressure, or are closed populations with long breed histories. These results provide new insights into the relationships among and the diversity within breeds of horses. In addition these results will facilitate future genome-wide association studies and investigations into genomic targets of selection.
207 citations
Authors
Showing all 13488 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Grätzel | 248 | 1423 | 303599 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Tobin J. Marks | 159 | 1621 | 111604 |
Johan Auwerx | 158 | 653 | 95779 |
Tony Pawson | 150 | 425 | 85196 |
Jack Hirsh | 146 | 734 | 86332 |
Alexander Belyaev | 142 | 1895 | 100796 |
R. L. McCarthy | 141 | 1238 | 115696 |
Harvey B Newman | 139 | 1594 | 88308 |
Guido Tonelli | 138 | 1458 | 97248 |
Elias Campo | 135 | 761 | 85160 |
Alberto Messineo | 134 | 1511 | 96492 |
Franco Ligabue | 134 | 1404 | 95389 |
Roberto Tenchini | 133 | 1390 | 94541 |
R. Bartoldus | 132 | 1624 | 97405 |