Institution
University of Perugia
Education•Perugia, Umbria, Italy•
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.
Papers published on a yearly basis
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TL;DR: In this paper, a precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1.GV to 1.8TV is presented based on 300 million events.
Abstract: A precise measurement of the proton flux in primary cosmic rays with rigidity (momentum/charge) from 1 GV to 1.8 TV is presented based on 300 million events. Knowledge of the rigidity dependence of the proton flux is important in understanding the origin, acceleration, and propagation of cosmic rays. We present the detailed variation with rigidity of the flux spectral index for the first time. The spectral index progressively hardens at high rigidities.
783 citations
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TL;DR: High-resolution radio images and optical polarization measurements of the blazar BL Lacertae reveal a bright feature in the jet that causes a double flare of radiation from optical frequencies to TeV γ-ray energies, as well as a delayed outburst at radio wavelengths that is identified with the acceleration and collimation zone predicted by the theories.
Abstract: Blazars are the most extreme active galactic nuclei. They possess oppositely directed plasma jets emanating at near light speeds from accreting supermassive black holes. According to theoretical models, such jets are propelled by magnetic fields twisted by differential rotation of the black hole's accretion disk or inertial-frame-dragging ergosphere1, 2, 3. The flow velocity increases outward along the jet in an acceleration and collimation zone containing a coiled magnetic field4, 5. Detailed observations of outbursts of electromagnetic radiation, for which blazars are famous, can potentially probe the zone. It has hitherto not been possible to either specify the location of the outbursts or verify the general picture of jet formation. Here we report sequences of high-resolution radio images and optical polarization measurements of the blazar BL Lacertae. The data reveal a bright feature in the jet that causes a double flare of radiation from optical frequencies to TeV -ray energies, as well as a delayed outburst at radio wavelengths. We conclude that the event starts in a region with a helical magnetic field that we identify with the acceleration and collimation zone predicted by the theories. The feature brightens again when it crosses a standing shock wave corresponding to the bright 'core' seen on the images.
783 citations
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TL;DR: A model in which the spontaneous membrane oscillations of neurons projecting from the striatum, in addition to the pattern of release of endogenous dopamine, bias the synapse towards preferential induction of LTP or LTD is proposed.
764 citations
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TL;DR: Beta-blockers are associated with a significant reduction in cardiac events in LQTS patients, particularly in those who were symptomatic before starting this therapy, and these events continue to occur while patients are on prescribed beta-blocker therapy.
Abstract: Background—β-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of β-blockers in this disorder have not been evaluated. Methods and Results—The study population comprised 869 LQTS patients treated with β-blockers. Effectiveness of β-blockers was analyzed during matched periods before and after starting β-blocker therapy, and by survivorship methods to determine factors associated with cardiac events while on prescribed β-blockers. After initiation of β-blockers, there was a significant (P<0.001) reduction in the rate of cardiac events in probands (0.97±1.42 to 0.31±0.86 events per year) and in affected family members (0.26±0.84 to 0.15±0.69 events per year) during 5-year matched periods. On-therapy survivorship analyses revealed that patients with cardiac symptoms before β-blockers (n=598) had a hazard ratio of 5.8 (95% CI, 3.7 to 9.1) for recurrent cardiac events (syncope, aborted cardiac arrest, or death) during β-blocker therapy compared with ...
762 citations
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Johns Hopkins University School of Medicine1, Johns Hopkins University2, University of Pisa3, University of Pittsburgh4, University of Padua5, Memorial Sloan Kettering Cancer Center6, University of Perugia7, University of Milan8, Curie Institute9, University of Sydney10, Spanish National Research Council11, Autonomous University of Madrid12, Kolling Institute of Medical Research13
TL;DR: In this retrospective multicenter study, the presence of the BRAF V600E mutation was significantly associated with increased cancer-related mortality among patients with PTC, and the association was not independent of tumor features.
Abstract: Importance BRAF V600E is a prominent oncogene in papillary thyroid cancer (PTC), but its role in PTC-related patient mortality has not been established. Objective To investigate the relationship between BRAF V600E mutation and PTC-related mortality. Design, Setting, and Participants Retrospective study of 1849 patients (1411 women and 438 men) with a median age of 46 years (interquartile range, 34-58 years) and an overall median follow-up time of 33 months (interquartile range, 13-67 months) after initial treatment at 13 centers in 7 countries between 1978 and 2011. Main Outcomes and Measures Patient deaths specifically caused by PTC. Results Overall, mortality was 5.3% (45/845; 95% CI, 3.9%-7.1%) vs 1.1% (11/1004; 95% CI, 0.5%-2.0%) (P Conclusions and Relevance In this retrospective multicenter study, the presence of the BRAF V600E mutation was significantly associated with increased cancer-related mortality among patients with PTC. Because overall mortality in PTC is low and the association was not independent of tumor features, how to use BRAF V600E to manage mortality risk in patients with PTC is unclear. These findings support further investigation of the prognostic and therapeutic implications of BRAF V600E status in PTC.
760 citations
Authors
Showing all 13488 results
Name | H-index | Papers | Citations |
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Michael Grätzel | 248 | 1423 | 303599 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Tobin J. Marks | 159 | 1621 | 111604 |
Johan Auwerx | 158 | 653 | 95779 |
Tony Pawson | 150 | 425 | 85196 |
Jack Hirsh | 146 | 734 | 86332 |
Alexander Belyaev | 142 | 1895 | 100796 |
R. L. McCarthy | 141 | 1238 | 115696 |
Harvey B Newman | 139 | 1594 | 88308 |
Guido Tonelli | 138 | 1458 | 97248 |
Elias Campo | 135 | 761 | 85160 |
Alberto Messineo | 134 | 1511 | 96492 |
Franco Ligabue | 134 | 1404 | 95389 |
Roberto Tenchini | 133 | 1390 | 94541 |
R. Bartoldus | 132 | 1624 | 97405 |