Institution
University of Perugia
Education•Perugia, Umbria, Italy•
About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.
Topics: Population, Large Hadron Collider, Immune system, Medicine, Catalysis
Papers published on a yearly basis
Papers
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TL;DR: Large numbers of donor T-cell clones specific for Aspergillus or cytomegalovirus antigens were generated and identified clones potentially responsible for causing GvHD by screening them for cross-reactivity against recipient mononuclear cells.
368 citations
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Cornell University1, University of Turin2, Polytechnic University of Turin3, Columbia University4, Katholieke Universiteit Leuven5, University of Würzburg6, Medical University of Graz7, University Hospital of Basel8, University of Pavia9, City of Hope National Medical Center10, University of Nebraska Medical Center11, University of Verona12, University of Eastern Piedmont13, University of Bologna14, European Institute of Oncology15, University of Perugia16, Janssen-Cilag17, Janssen Pharmaceutica18, New York University19
TL;DR: By integrating massive sequencing strategies, this work provides a comprehensive characterization of driver genetic alterations (somatic point mutations, copy number alterations, and gene fusions) in ALK(-) ALCLs and identifies activating mutations of JAK1 and/or STAT3 genes that led to constitutive activation of the JAK/STAT3 pathway.
367 citations
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TL;DR: The immortalized cell line (BV‐2) shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity, and represents a suitable model for in vitro studies of activated microglial cells.
Abstract: Murine cultured microglial cells were immortalized after infection with a v-raf/v-myc recombinant retrovirus This immortalized cell line (BV-2) shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity BV-2 cells are not constitutively able to kill tumor cells in vitro, but acquire antitumor activity following an increase in [Ca++]i BV-2 cells, like microglial cells, are however, distinct from peripheral macrophages by their expression of inwardly rectifying K+ channels in concert with a lack in outwardly rectifying K+ channels and the formation of spineous processes The BV-2 cell line thus represents a suitable model for in vitro studies of activated microglial cells
366 citations
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TL;DR: Evidence has accumulated to suggest important roles for hydrogen sulfide as a mediator of several aspects of gastrointestinal and liver function, and inhibitors of hydrogen sulfides synthesis and drugs that can generate safe levels in vivo have been developed and are permitting interventional studies in experimental models and, in the near future, humans.
365 citations
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TL;DR: Detailed characterization of EVs released by human adipose derived‐MSCs indicate that MSC‐EVs possess effective anti‐inflammatory properties, making them potential therapeutic agents more handy and safe than MSCs.
Abstract: Mesenchymal Stem Cells (MSCs) are effective therapeutic agents enhancing the repair of injured tissues mostly through their paracrine activity. Increasing evidences show that besides the secretion of soluble molecules, the release of extracellular vesicles (EVs) represents an alternative mechanism adopted by MSCs. Since macrophages are essential contributors toward the resolution of inflammation, which has emerged as a finely orchestrated process, the aim of the present study was to carry out a detailed characterization of EVs released by human adipose derived-MSCs to investigate their involvement as modulators of MSC anti-inflammatory effects inducing macrophage polarization. The EV-isolation method was based on repeated ultracentrifugations of the medium conditioned by MSC exposed to normoxic or hypoxic conditions (EVNormo and EVHypo ). Both types of EVs were efficiently internalized by responding bone marrow-derived macrophages, eliciting their switch from a M1 to a M2 phenotype. In vivo, following cardiotoxin-induced skeletal muscle damage, EVNormo and EVHypo interacted with macrophages recruited during the initial inflammatory response. In injured and EV-treated muscles, a downregulation of IL6 and the early marker of innate and classical activation Nos2 were concurrent to a significant upregulation of Arg1 and Ym1, late markers of alternative activation, as well as an increased percentage of infiltrating CD206pos cells. These effects, accompanied by an accelerated expression of the myogenic markers Pax7, MyoD, and eMyhc, were even greater following EVHypo administration. Collectively, these data indicate that MSC-EVs possess effective anti-inflammatory properties, making them potential therapeutic agents more handy and safe than MSCs. Stem Cells Translational Medicine 2017 Stem Cells Translational Medicine 2017;6:1018-1028.
364 citations
Authors
Showing all 13488 results
Name | H-index | Papers | Citations |
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Michael Grätzel | 248 | 1423 | 303599 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Tobin J. Marks | 159 | 1621 | 111604 |
Johan Auwerx | 158 | 653 | 95779 |
Tony Pawson | 150 | 425 | 85196 |
Jack Hirsh | 146 | 734 | 86332 |
Alexander Belyaev | 142 | 1895 | 100796 |
R. L. McCarthy | 141 | 1238 | 115696 |
Harvey B Newman | 139 | 1594 | 88308 |
Guido Tonelli | 138 | 1458 | 97248 |
Elias Campo | 135 | 761 | 85160 |
Alberto Messineo | 134 | 1511 | 96492 |
Franco Ligabue | 134 | 1404 | 95389 |
Roberto Tenchini | 133 | 1390 | 94541 |
R. Bartoldus | 132 | 1624 | 97405 |