University of Perugia

About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.

Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high‐risk abdominal surgery

Abstract: Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery.

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

Abstract: NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be determined what specific molecular interactions are involved and whether NK cells control metastatic progression and/or the route of dissemination. Here we show that human melanoma cell lines derived from LN metastases express ligands for natural cytotoxicity receptors (NCRs) and DNAX accessory molecule-1 (DNAM-1), two emerging NK cell receptors key for cancer cell recognition, but not NK group 2 member D (NKG2D). Compared with cell lines derived from metastases taken from other anatomical sites, LN metastases were more susceptible to NK cell lysis and preferentially targeted by adoptively transferred NK cells in a xenogeneic model of cell therapy. In mice, DNAM-1 and NCR ligands were also found on spontaneous melanomas and melanoma cell lines. Interference with DNAM-1 and NCRs by antibody blockade or genetic disruption reduced killing of melanoma cells. Taken together, these results show that DNAM-1 and NCRs are critical for NK cell-mediated innate immunity to melanoma cells and provide a background to design NK cell-based immunotherapeutic strategies against melanoma and possibly other tumors.

Theoretical analysis and performance of OFDM signals in nonlinear AWGN channels

Abstract: Orthogonal frequency-division multiplexing (OFDM) baseband signals may be modeled by complex Gaussian processes with Rayleigh envelope distribution and uniform phase distribution, if the number of carriers is sufficiently large. The output correlation function of instantaneous nonlinear amplifiers and the signal-to-distortion ratio can be derived and expressed in an easy way. As a consequence, the output spectrum and the bit-error rate (BER) performance of OFDM systems in nonlinear additive white Gaussian noise channels are predictable both for uncompensated amplitude modulation/amplitude modulation (AM/AM) and amplitude modulation/pulse modulation (AM/PM) distortions and for ideal predistortion. The aim of this work is to obtain the analytical expressions for the output correlation function of a nonlinear device and for the BER performance. The results in closed-form solutions are derived for AM/AM and AM/PM curves approximated by Bessel series expansion and for the ideal predistortion case.

The spectrum and morphology of the Fermi bubbles

Abstract: The Fermi bubbles are two large structures in the gamma-ray sky extending to 55 deg above and below the Galactic center. We analyze 50 months of Fermi Large Area Telescope data between 100 MeV and 500 GeV above 10 deg in Galactic latitude to derive the spectrum and morphology of the Fermi bubbles. We thoroughly explore the systematic uncertainties that arise when modeling the Galactic diffuse emission through two separate approaches. The gamma-ray spectrum is well described by either a log parabola or a power law with an exponential cutoff. We exclude a simple power law with more than 7 sigma significance. The power law with an exponential cutoff has an index of 1.90+/-0.2 and a cutoff energy of 110+/- 50 GeV. We find that the gamma-ray luminosity of the bubbles is 4.4(+)2.4(-0.9 ) 10(exp 37) erg s-1. We confirm a significant enhancement of gamma-ray emission in the south-eastern part of the bubbles, but we do not find significant evidence for a jet. No significant variation of the spectrum across the bubbles is detected. The width of the boundary of the bubbles is estimated to be 3.4(+)3.7(-)2.6 deg. Both inverse Compton (IC) models and hadronic models including IC emission from secondary leptons t the gamma-ray data well. In the IC scenario, the synchrotron emission from the same population of electrons can also explain the WMAP and Planck microwave haze with a magnetic field between 5 and 20 micro-G.

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.

Abstract: Glucocorticoid-induced tumor necrosis factor receptor (GITR) on T cells and its natural ligand, GITRL, on accessory cells contribute to the control of immune homeostasis. Here we show that reverse signaling through GITRL after engagement by soluble GITR initiates the immunoregulatory pathway of tryptophan catabolism in mouse plasmacytoid dendritic cells, by means of noncanonical NF-κB–dependent induction of indoleamine 2,3-dioxygenase (IDO). The synthetic glucocorticoid dexamethasone administered in vivo activated IDO through the symmetric induction of GITR in CD4+ T cells and GITRL in plasmacytoid dendritic cells. The drug exerted IDO-dependent protection in a model of allergic airway inflammation. Modulation of tryptophan catabolism via the GITR-GITRL coreceptor system might represent an effective therapeutic target in immune regulation. Induction of IDO could be an important mechanism underlying the anti-inflammatory action of corticosteroids.