University of Perugia

About: University of Perugia is a education organization based out in Perugia, Umbria, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 13365 authors who have published 39516 publications receiving 1265601 citations. The organization is also known as: Universitá degli Studi di Perugia & Universita degli Studi di Perugia.

Stochastic resonance in bistable systems.

Abstract: The relaxation properties of a stochastic bistable system perturbed by a periodic low-frequency forcing term is investigated by means of analog simulation. The so-called stochastic resonance phenomenon is revealed under diverse experimental conditions. Its dependence on the parameters of both the periodic perturbation and the forced system is explained theoretically.

EML4-ALK Rearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues

Abstract: A fusion gene, echinoderm microtubule associated protein like 4 – anaplastic lymphoma kinase (EML4-ALK), with transforming activity has recently been identified in a subset of non-small cell lung cancer (NSCLC), but its pathogenetic, diagnostic, and therapeutic roles remain unclear. Both frequency and type of EML4-ALK transcripts were investigated by reverse transcription PCR in 120 frozen NSCLC specimens from Italy and Spain; non-neoplastic lung tissues taken far from the tumor were used as controls. In cases carrying the fusion transcript, we determined EML4-ALK gene and protein levels using fluorescence in situ hybridization, Western blotting, and immunoprecipitation. We also analyzed ALK protein levels in paraffin samples from 662 NSCLC specimens, including the 120 cases investigated in the molecular studies. EML4-ALK transcripts (variants 1 and 3) were detected in 9 of 120 NSCLC samples but were not specific for NSCLC since they were also found in non-cancerous lung tissues taken far from the tumor. Notably, no transcripts were detected in matching tumor samples from these patients. Fluorescence in situ hybridization analysis of cases expressing EML4-ALK transcripts showed that only a minority of cells harbored the EML4-ALK gene. None of these cases was found to express the EML4-ALK protein as examined by immunohistochemistry, Western blotting, and immunoprecipitation. The EML4-ALK transcript cannot be regarded as a specific diagnostic tool for NSCLC. Our results show therefore that the causal role and value of EML4-ALK as a therapeutic target remain to be defined.

Multiple solutions for nonhomogeneous Schrödinger–Kirchhoff type equations involving the fractional p -Laplacian in $${\mathbb {R}}^N$$ R N

Abstract: In this paper we investigate the existence of multiple solutions for the nonhomogeneous fractional p-Laplacian equations of Schrodinger–Kirchhoff type $$\begin{aligned} M\left( \iint _{R^{2N}}\frac{|u(x)-u(y)|^p}{|x-y|^{N+ps}}dxdy\right) (-\varDelta )^s_pu+V(x)|u|^{p-2}u=f(x,u)+g(x) \end{aligned}$$ in $${\mathbb {R}}^N$$ , where $$(-\varDelta )^s_p$$ is the fractional p-Laplacian operator, with $$0