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Institution

University of Pittsburgh

EducationPittsburgh, Pennsylvania, United States
About: University of Pittsburgh is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 87042 authors who have published 201012 publications receiving 9656783 citations. The organization is also known as: Pitt & Western University of Pennsylvania.


Papers
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Journal ArticleDOI
TL;DR: The Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.
Abstract: The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells have long been implicated in defense against candidiasis, whereas the role of Th17 cells remains controversial. IL-17 mediates inflammatory pathology in a gastric model of mucosal candidiasis, but is host protective in disseminated disease. Here, we directly compared Th1 and Th17 function in a model of OPC. Th17-deficient (IL-23p19(-/-)) and IL-17R-deficient (IL-17RA(-/-)) mice experienced severe OPC, whereas Th1-deficient (IL-12p35(-/-)) mice showed low fungal burdens and no overt disease. Neutrophil recruitment was impaired in IL-23p19(-/-) and IL-17RA(-/-), but not IL-12(-/-), mice, and TCR-alphabeta cells were more important than TCR-gammadelta cells. Surprisingly, mice deficient in the Th17 cytokine IL-22 were only mildly susceptible to OPC, indicating that IL-17 rather than IL-22 is vital in defense against oral candidiasis. Gene profiling of oral mucosal tissue showed strong induction of Th17 signature genes, including CXC chemokines and beta defensin-3. Saliva from Th17-deficient, but not Th1-deficient, mice exhibited reduced candidacidal activity. Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.

931 citations

Journal ArticleDOI
26 Aug 1994-Cell
TL;DR: In vivo evidence is provided that p53-dependent apoptosis, occurring in response to oncogenic events, is a critical regulator of tumorigenesis.

930 citations

Journal ArticleDOI
TL;DR: Results for distributed model predictive control are presented, focusing on the coordination of the optimization computations using iterative exchange of information and the stability of the closed-loop system when information is exchanged only after each iteration.
Abstract: The article presents results for distributed model predictive control (MPC), focusing on i) the coordination of the optimization computations using iterative exchange of information and ii) the stability of the closed-loop system when information is exchanged only after each iteration. Current research is focusing on general methods for decomposing large-scale problems for distributed MPC and methods for guaranteeing stability when multiple agents are controlling systems subject to abrupt changes.

930 citations

Journal ArticleDOI
TL;DR: The factors that appear important for the constructive remodeling of ECM biologic scaffolds are its ability to be rapidly and completely degraded with the generation of downstream bioactive molecules and the ability to engineer its mechanical properties at the time of implantation through an understanding of its collagen fiber microstructure.

930 citations

Journal ArticleDOI
TL;DR: In this paper, the authors draw on a review of theoretical and empirical literature on scale, relevant research on reform implementation, and original research to synthesize and articulate a more multidimensional conceptualization.
Abstract: The issue of “scale” is a key challenge for school reform, yet it remains undertheorized in the literature. Definitions of scale have traditionally restricted its scope, focusing on the expanding number of schools reached by a reform. Such definitions mask the complex challenges of reaching out broadly while simultaneously cultivating the depth of change necessary to support and sustain consequential change. This article draws on a review of theoretical and empirical literature on scale, relevant research on reform implementation, and original research to synthesize and articulate a more multidimensional conceptualization. I develop a conception of scale that has four interrelated dimensions: depth, sustainability, spread, and shift in reform ownership. I then suggest implications of this conceptualization for reform strategy and research design.

930 citations


Authors

Showing all 87737 results

NameH-indexPapersCitations
JoAnn E. Manson2701819258509
Graham A. Colditz2611542256034
Yi Chen2174342293080
David J. Hunter2131836207050
David Miller2032573204840
Rakesh K. Jain2001467177727
Lewis C. Cantley196748169037
Dennis W. Dickson1911243148488
Terrie E. Moffitt182594150609
Dennis S. Charney179802122408
Ronald C. Petersen1781091153067
David L. Kaplan1771944146082
Jasvinder A. Singh1762382223370
Richard K. Wilson173463260000
Deborah J. Cook173907148928
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023260
20221,089
202111,151
202010,407
20199,333
20188,577